Apologies if the is covered somewhere else, or if this is the wrong place for it.

There is no DFU driver for Windows on ARM, this means that you cannot program the Uno R4 from this platform. Im not sure who needs to write this, but it will become and increasing problem as these computers become more popular ie Microsoft Surface 11 is ARM only.

There have been some discussions on the forums about work around's using things like Zadig and libwdi, but none of them have worked for me. There are others that try to load unsigned drivers but that is not a good long-term solution.
https://forum.arduino.cc/t/windows-on-arm-with-a-qualcomm-x-elite/1278045/2
https://forum.arduino.cc/t/no-duf-capable-usb-device-aviable-r4-minima-cloud-editor-on-surface-pro-x-windows-10-arm-64/1305430
pbatard/libwdi#155 (comment)

I have also looked at Renesas for a solution, but they say they are not supporting Windows on ARM yet
https://community.renesas.com/mcu/tools/f/tools-forum/52448/e2-emulator-drivers-for-windows-11-arm

Just to be clear I am not talking about the IDE, that works fine under emulation. I it is just the DFU driver for the Uno R4 and drivers cannot run in emulation.