from abc import ABC

class Root(ABC):
    def __init_subclass__(cls, **kwargs):
        if cls.__name__ == "Multi":
            # issubclass(Second, First)  # Wouldn't trigger the bug for Second
            issubclass(First, Second)  # Triggers the bug for First
            issubclass(Second, First)  # Doesn't trigger the bug for Second

class First(Root): ...
class Second(Root): ...
class Multi(First, Second): ...

assert not issubclass(First, First)  # This is the bug.
assert issubclass(Second, Second)

print("bug!")