Hello,
The recent fix to Profiler has indeed reduced the size of generated files, but in my case the performance is still very slow. From what I gather, it has to do with the fact that I have around 600-700 depreciation notices on list pages in my CMS (vendor library dependent on Twig, can not upgrade unfortunately). Now I am not sure this is something that can or should be fixed on your side, but gathering the depreciation notices does have a big hit on app performance. Thanks in advance for feedback.