Bangaren jikin da ake samun cuta mai karya garkuwar jiki
 Bangaren jikin da ake samun cuta mai karya garkuwar jiki | |
|---|---|
| Bayanai | |
| Ƙaramin ɓangare na |
viral tropism (en)  |
| Facet of (en) | Kanjamau |
Bangaren Kwayar cutar kanjamau yana nufin wani bangare na halitta na jiki wanda kwayar cutar rashin lafiyar ɗan adam ( HIV ) ke kamuwa da ita kuma ta kwaikwayi.. Ana auna ƙwayar cutar kanjamau ta ƙwayar cuta ta majiyyaci ta Trofile assay kwayar cutar kanjamau na iya kama kwayar halittar dan adam iri-iri kamar CD4+ helper T-cells da macrophages waɗanda ke bayyana kwayoyin CD4 akan saman su. Shigar da kwayar cutar HIV-1 zuwa macrophages da sel masu taimako na T ba kawai ta hanyar hulɗar glycoproteins na virion envelope ( gp120 ) tare da kwayoyin CD4 a kan kwayoyin da aka yi niyya amma har ma tare da masu karɓar chemokine. Macrophage (M-tropics) nau'in HIV-1, ko nau'ikan da ba syncitia-inducing (NSI) suna amfani da mai karɓar beta-chemokine CCR5 don shiga cikin dan adam kuma suna iya yaduwa a cikin macrophages da CD4+ T-cell. [1] Yanzu ana kiran waɗannan nau'ikan ƙwayoyin virus din R5. [2] wadannan halittun jiki masu ansar kwayoyin cuta na al'ada kamar- RANTES, furotin mai kumburi na macrophage (MIP) -1β da MIP-1a-suna iya kashe kwayar cutar HIV-1 kafin ta shiga cikin tantanin halitta. duka kwayoyin cutar kanjamau na amfani da wannan coreceptor na CCR5 ta kusan dukkanin shiga cikin jiki na farko na ba tare da la'akari da nau'in jinsin ƙwayoyin cuta ba.
T-tropic(nau'in kwayar cutar kanjamau), ko syncitia -inducing (SI) nau'i-nau'i suna yaduwa a cikin (CD4 + T-cell 1) da kuma a cikin (macrophages) kuma suna amfani da alpha-chemokine, CXCR4, domin shiga cikin tantanin halitta. [3]Yanzu ana kiran waɗannan nau'ikan ƙwayoyin cuta X4. [4]Alpha-chemokine SDF-1, ligand don CXCR4, yana hana yaduwar (T-tropic HIV-1) . Yana yin haka ta hanyar rage ka'idodin CXCR4 akan saman waɗannan tantanin halittar. Kwayoyin cuta masu amfani da CCR5 domin shiga kawai ana kiran su da R5, waɗanda ke amfani da CXCR4 kawai ana kiran su X4, waɗanda ke amfani da duka biyun, X4R5.yana yin haka ne ta hanyar amfani rashin bayyana coreceptor kadai. kamar yadda ba duka kanjamau na R5 ke iya amfani da CCR5 a kan macrophages domin yada cuta. [1]
Awon tropile
[gyara sashe | gyara masomin]Gwajin Trofile gwaji ne na jini ne wanda ke gano yanayin zafi na kwayar cutar kanjamau [3]. gwajin kwayoyin halitta, Monogram Biosciences ne ya samar da Trofile don amfani da maganin cutar kanjamau. . Manufar tantancewar ita ce gano yanayin zafi na nau'in kwayar cutar kanjamau na - R5, X4, ko haɗin waɗannan da aka sanu da duka biyu.. Sakamakon ya nuna wadanda keda da kwayar cutar da ke shiga sel ta amfani da R5 co-receptor, zasu fi dorewa lokaci mai tsawo da lapiya, akan masu amfani da X4 co-receptor. Marasa lafiya masu nau'in HIV waɗanda suka fi son mai karɓar R5 suna da lafiya fiye da waɗanda ke da nau'ikan da suka fi son X4. Duk da haka, a tsawon lokacin cutar, yawan ƙwayar cuta na majiyyaci na iya jurewa "canjin yanayin zafi" daga R5 zuwa X4.
Manazarta
[gyara sashe | gyara masomin]- ↑ 1.0 1.1 Coakley, E.; Petropoulos, C. J.; Whitcomb, J. M. (2005). "Assessing chemokine co-receptor usage in HIV". Curr. Opin. Infect. Dis. 18 (1): 9–15. doi:10.1097/00001432-200502000-00003. PMID 15647694. S2CID 30923492
- ↑ Berger, EA; Doms, RW; Fenyö, EM; Korber, BT; Littman, DR; Moore, JP; Sattentau, QJ; Schuitemaker, H; et al. (1998). "A new classification for HIV-1". Nature. 391 (6664): 240. Bibcode:1998Natur.391..240B. doi:10.1038/34571. PMID 9440686. S2CID 2159146
- ↑ 3.0 3.1 Whitcomb, JM; Huang, W; Fransen, S; et al. (2007). "Development and characterization of a novel single-cycle recombinant virus assay to determine human immunodeficiency virus type 1 coreceptor tropism". Antimicrob Agents Chemother. 51 (2): 566–575. doi:10.1128/aac.00853-06. PMC 1797738. PMID 17116663
- ↑ .
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