On tourniquet shock (ToS) rat model, it was found that the reactivity of isolated perfused aortic... more On tourniquet shock (ToS) rat model, it was found that the reactivity of isolated perfused aortic ring to noradrenaline was decreased, while the cGMP content of the aortic tissue was increased. These ToS-induced changes could be potentiated or attenuated respectively by perfusion with NO-precursor, L-arginine, or NO-synthesis inhibitor L-NNA independent of the presence of vascular endothelium. Guanylate cyclase inhibitor, methylene blue, could also attenuate the aortic reactivity. All these results suggest that the aortic musculature can produce a NO-LRF factor capable of lowering the vascular reactivity of the ToS animals. That L-arginine can ameliorate while L-NNA can exacerbate ToS, suggest that NO-LRF do play an adaptive role in the protective mechanism of the organism during ToS.
Endothelin is a bioactive polypeptide released from vascular endothelium, which has a strong acti... more Endothelin is a bioactive polypeptide released from vascular endothelium, which has a strong action promoting vascular contraction, proliferation and hypertrophy of vascular smooth muscle cells. The present investigation was performed on the hypertensive rat produced by narrowing abdominal aorta and drinking saline. It was observed that the level of plasma endothelin in the hypertensive rats was doubled (9.70 +/- 0.68 vs. sham group 4.11 +/- 0.33 pg/ml, P < 0.01), and administration of specific endothelin-antiserum into hypertensive rats significantly attenuated the increase in the blood pressure (18.97 + 1.32 vs. 27.33 + 0.09 kPa in untreated hypertensive rats, P < 0.01), and dramatically ameliorated malfunction resulting from myocardial hypertrophy. The results suggest that endothelin is an important factor in the pathogenesis of hypertension, and that inhibition of endothelin action may be a new effective way in prevention and therapy of hypertension.
Cho đến nay, có thể nói các nhà nghiên cứu đã tiếp cận Truyện Kiều của Nguyễn Du ở hầu hết mọi gó... more Cho đến nay, có thể nói các nhà nghiên cứu đã tiếp cận Truyện Kiều của Nguyễn Du ở hầu hết mọi góc độ, khía cạnh, trong đó có khía cạnh ngôn từ với các phương diện như: ngữ âm, từ vựng, ngữ nghĩa, và cú pháp. Vì vậy, trong bài viết này, chúng tôi không nhằm vẽ lại cấu trúc ngôn từ nghệ thuật của Truyện Kiều mà chỉ tập trung làm rõ cái hay của tiếng Việt mà cấu trúc ngôn từ nghệ thuật của Truyện Kiều đem lại từ hai khía cạnh: ngữ âm – nhạc điệu, và từ vựng – tính đa nghĩa.
On tourniquet shock (ToS) rat model, it was found that the reactivity of isolated perfused aortic... more On tourniquet shock (ToS) rat model, it was found that the reactivity of isolated perfused aortic ring to noradrenaline was decreased, while the cGMP content of the aortic tissue was increased. These ToS-induced changes could be potentiated or attenuated respectively by perfusion with NO-precursor, L-arginine, or NO-synthesis inhibitor L-NNA independent of the presence of vascular endothelium. Guanylate cyclase inhibitor, methylene blue, could also attenuate the aortic reactivity. All these results suggest that the aortic musculature can produce a NO-LRF factor capable of lowering the vascular reactivity of the ToS animals. That L-arginine can ameliorate while L-NNA can exacerbate ToS, suggest that NO-LRF do play an adaptive role in the protective mechanism of the organism during ToS.
Endothelin is a bioactive polypeptide released from vascular endothelium, which has a strong acti... more Endothelin is a bioactive polypeptide released from vascular endothelium, which has a strong action promoting vascular contraction, proliferation and hypertrophy of vascular smooth muscle cells. The present investigation was performed on the hypertensive rat produced by narrowing abdominal aorta and drinking saline. It was observed that the level of plasma endothelin in the hypertensive rats was doubled (9.70 +/- 0.68 vs. sham group 4.11 +/- 0.33 pg/ml, P < 0.01), and administration of specific endothelin-antiserum into hypertensive rats significantly attenuated the increase in the blood pressure (18.97 + 1.32 vs. 27.33 + 0.09 kPa in untreated hypertensive rats, P < 0.01), and dramatically ameliorated malfunction resulting from myocardial hypertrophy. The results suggest that endothelin is an important factor in the pathogenesis of hypertension, and that inhibition of endothelin action may be a new effective way in prevention and therapy of hypertension.
Cho đến nay, có thể nói các nhà nghiên cứu đã tiếp cận Truyện Kiều của Nguyễn Du ở hầu hết mọi gó... more Cho đến nay, có thể nói các nhà nghiên cứu đã tiếp cận Truyện Kiều của Nguyễn Du ở hầu hết mọi góc độ, khía cạnh, trong đó có khía cạnh ngôn từ với các phương diện như: ngữ âm, từ vựng, ngữ nghĩa, và cú pháp. Vì vậy, trong bài viết này, chúng tôi không nhằm vẽ lại cấu trúc ngôn từ nghệ thuật của Truyện Kiều mà chỉ tập trung làm rõ cái hay của tiếng Việt mà cấu trúc ngôn từ nghệ thuật của Truyện Kiều đem lại từ hai khía cạnh: ngữ âm – nhạc điệu, và từ vựng – tính đa nghĩa.
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