Carlo Bulletti

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Richard Tabor Greene

PUT

Ayse Asatekin

Tufts University

Mark van den Boogaard

Radboud University Nijmegen

Abdullah M. Asiri

King AbdulAziz University (KAU) Jeddah, Saudi Arabia

Heather Baid

University of Brighton

Miklas Scholz

University of Salford

Steve J Bull

Newcastle University

Arnaldo A da Silva

Hospital Israelita Albert Einstein

Handika Tri Tawangsasi

Universitas Airlangga

Anthony Stickland

University of Melbourne

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Papers by Carlo Bulletti

Embryonic Causes of Implantation Failure: A Systematic Review and Procedures To Optimize Successful Embryo Transfer

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Preliminary report on progesterone effect on peripheral estrone sulfate metabolism

V M Jasonni, C Bulletti, F Franceschetti, P Ciotti, M Bonavia, A P Ferraretti, C Flamigni, 1983

The effect of progesterone (P) on peripheral estrone sulfate (E1S) was investigated in postmenopa... more The effect of progesterone (P) on peripheral estrone sulfate (E1S) was investigated in postmenopausal women using E1S constant infusions. The metabolic clearance rate of E1S (MCRE1S) was significantly lowered by P administration (p less than 0.01), while no significant changes were observed for E1S----E1 conversion ratio. The present findings suggest that P can affect the E1S peripheral fate inducing deep changes in estrogen equilibrium.

The New Phenotype of a Successful Medical Career. Something is Wrong?

Biomedical Journal of Scientific & Technical Research

Importance: Liberal democracies based on merit and transparency have so far been rewarded by scie... more Importance: Liberal democracies based on merit and transparency have so far been rewarded by scientific and industrial production with the generation of greater wealth. However, meritocracy contains some weaknesses. The non-univocal definition of merit, the changed attribution of value between meritocracy and mediocracy, the lack of equal opportunities for the generation of skills as credentials of merit, and finally the parameters identified for its attribution as well as the easy instrumental manipulation of the same. Objective: Therefore, a deep rethinking of merit, its essence, its value, and its evaluation seems an evident need. Evidence reviews: Recently, in several healthcare compartments around the world, mediocracy was received attention and valorization for a lower attitude toward clinical performances but the highest attitude to passive prosthetic ramifications of administrative determinations. A new category capable of doing their bureaucratic work well without any personal thinking. The so-called coachable represents the new credential for the progression of medical careers. Findings: A new phenotype of a medical doctor with great aspiration for a career is substituting pure competent. Merit in the definition that we know, is still the prevalent credential usable for medical career promotion? What is the system for the progression of medical careers in democracies? Conclusion: Hereafter we are reporting the journey of a young aspirant to become a good doctor and the difficulties related to the critical parameters used to identify the talents and the criteria to accept to advance in a career. Relevance: Whatever would be the perspective intrinsic value of merit in the forthcoming society we must defend the meritocratic equality of opportunity as the opposite of arbitrary discrimination, to be attractive for a young scientist.

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Telemedicine in IVF Programs

Biomedical Journal of Scientific & Technical Research

Telemedicine has proven to be a valuable tool in the field of infertility management, allowing he... more Telemedicine has proven to be a valuable tool in the field of infertility management, allowing healthcare providers to offer remote consultations, monitoring, and support to patients. There are several ways in which telemedicine is utilized in infertility management: Initial Consultations: Telemedicine enables patients to have their initial consultations with fertility specialists remotely. This saves time and eliminates the need for patients to travel long distances to see a specialist. During these virtual consultations, patients can discuss their medical history, share relevant test results, and receive guidance on further diagnostic tests or treatment options. Test Result Discussions: Many diagnostic tests, such as blood hormone level tests or semen analysis, can be conducted locally, and the results can be shared electronically with the fertility specialist. Through telemedicine, the specialist can discuss the test results with the patient, explain their implications, and recommend appropriate treatment options based on the findings. Treatment Planning: Telemedicine allows fertility specialists to develop personalized treatment plans for patients remotely. After reviewing the patient's medical history, diagnostic test results, and any other relevant information, the specialist can discuss the treatment options, such as medication protocols or assisted reproductive techniques (e.g., in vitro fertilization), and address any concerns or questions the patient may have. Medication Monitoring: In some cases, fertility treatments involve medication protocols that require careful monitoring. Telemedicine facilitates remote monitoring of a patient's progress during treatment cycles. Patients can share their salivary estradiol measurements, self-performed US examination through specific Philips devices, symptoms, medication adherence, and any side effects they may be experiencing through virtual check-ins with their healthcare providers. This allows for adjustments to be made in realtime, ensuring optimal treatment outcomes. Emotional Support: Infertility can be emotionally challenging for individuals and couples. Telemedicine provides an avenue for regular emotional support, counseling, or therapy sessions with mental health professionals who specialize in infertility. These sessions can be conducted via video conferencing platforms, offering a safe and confidential environment for patients to discuss their emotional well-being and cope with the psychological impact of infertility. Follow-up Visits: After initiating treatment, patients typically require follow-up visits to monitor progress and make any necessary adjustments to the treatment plan. Telemedicine enables virtual follow-up visits, where patients can discuss their experiences, report any changes or concerns, and receive guidance from their healthcare providers without the need for in-person visits unless absolutely necessary.

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Artificial intelligence algorithms for optimizing assisted reproductive technology programs: A systematic review

Global Translational Medicine

Artificial intelligence (AI) has been experiencing rapid growth in recent years, and numerous app... more Artificial intelligence (AI) has been experiencing rapid growth in recent years, and numerous applications are improving the single-step efficiency of the whole assisted reproductive technology (ART) procedure. In this review, we collected all the algorithms supplying ART and selected those supporting the clinical assistance to the procedure up to the successful attempt. Those with a clear role in improving ART performances were further selected. We found a questionnaire-based algorithm identifying patients at risk for endometriosis with early management and better fertility outcome. An algorithm can detect the values of simple gamete production (male) and reservoir (female) according to gradual scale allocation, and display themas normal or abnormal, spontaneousor stimulated gamete production. This can provide significant benefits for infertile couples undergoing diagnostic and therapeutic journeys. The calculators for the starting dose of gonadotropins and the trigger timing durin...

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The uterus : endometrium and myometrium

Preliminary report on the use of progesterone vaginal suppositories in the hormonal replacement therapy in postmenopaus E

Journal of Steroid Biochemistry, 1986

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Estrogen provocation test: lack of correlation between LH and 17-beta-estradiol basal levels and LH peak response in hypothalamic chronic anovulation

Acta Europaea fertilitatis

ABSTRACT

Rapid and specific ria of serum estrone sulfate with selective solid phase extraction

Journal of Steroid Biochemistry, 1989

The methods commonly used to evaluate conjugated steroids require hydrolysis and chromatographic ... more The methods commonly used to evaluate conjugated steroids require hydrolysis and chromatographic purification. To avoid these steps, a simple method involving selective solid phase extraction and RIA using a highly specific antiserum for estrone sulfate (E1S) has been evolved. A Bond-Elut C2 cartridge was used for solid phase extraction of estrone (E1) and E1S; recoveries were 80 and 90% respectively. The intra- and inter assay precision of the assay at 3 serum levels, were 6.5, 10.4 and 4.4 and 12.7, 13.9 and 7.4% respectively. Accuracy, tested by linearity and recovery tests, was acceptable. A good correlation exists between a conventional enzymatic method and the proposed method. The latter is less time consuming and more reliable, thus providing a rapid assay to evaluate E1 and E1S in the same serum sample.

Effects of desametazone in patients affected by hyper-prolactinemia

Acta Europaea fertilitatis, 1980

Estrone sulphate and estrone splanchnic extraction in postmenopausal women

Acta Europaea fertilitatis, 1982

The splanchnic extraction of estrone sulphate (E1 S) and estrone (E1) was calculated in post-meno... more The splanchnic extraction of estrone sulphate (E1 S) and estrone (E1) was calculated in post-menopausal women undergoing cardiac catheterization for diagnostic purposes. The results showed a net uptake for E1 by the splanchnic area, liver included, whereas the splanchnic extraction of E1 S was not similar for each subject. Anyway the results clearly showed that the splanchnic area does not release significant amount of E1 S into the blood in the post-menopausal women.

Analysis of estrone sulphate levels in post-menopausal women with and without endometrial cancer

European journal of gynaecological oncology, 1982

In post-menopausal women, the role of Estrone sulphate (E1S) has not been clearly defined, and fe... more In post-menopausal women, the role of Estrone sulphate (E1S) has not been clearly defined, and few data are available in the literature. The present study concerns the plasma E1S levels in post-menopausal women with and without endometrial cancer; the results showed that the E1S levels are related to body size but not to endometrial cancer as the free estrogens.

Mathematical evaluation of the gonadotropin basal levels in hypothalamic chronic anovulation

Acta Europaea fertilitatis, 1982

[Induction of ovulation with bromocriptine. Results of 120 patients with hyperprolactinemia]

Minerva ginecologica

Preliminary report on progesterone effect on peripheral estrone sulfate metabolism

Acta Europaea fertilitatis

[Efficacy and tolerability of danazol in the treatment of menorrhagia syndrome: multicenter study]

Minerva ginecologica, 1987

[Hypothalamic phospholipid liposomes in the treatment of the climacteric syndrome]

Minerva ginecologica, 1989

Phospholipid liposomes have a dopaminergic effect on the human brain. Changes in prolactin and gr... more Phospholipid liposomes have a dopaminergic effect on the human brain. Changes in prolactin and growth hormone secretion have been observed in humans given phospholipid liposomes. The authors have investigated the therapeutic efficacy of hypothalamic phospholipids in the menopausal syndrome. The study was an open trial on 37 outpatients treated with 1 and 2 ampoules i.m. of a preparation of phospholipids (in the form of unilamellar liposomes) for a period of six months. The therapeutic effects were assessed by means of the Hamilton rating scale, MMPI (Minnesota multiphasic inventory test), and a list of psychosomatic symptoms (LSP). In the patients no change in FSH, LH, PRL, or E2 secretion was observed, whereas the neurotic symptomatology appeared remarkably reduced.

Estrone sulfate, estrone and estradiol concentrations in normal and cirrhotic postmenopausal women

Steroids, 1983

Circulating levels (mean +/- SD) of estrone sulfate (E1S), estrone (E1) and estradiol-17 beta (E2... more Circulating levels (mean +/- SD) of estrone sulfate (E1S), estrone (E1) and estradiol-17 beta (E2) were measured in normal and cirrhotic postmenopausal women matched for body weight and age. In cirrhotic postmenopausal women, the E1S concentrations (201 +/- 46 pg/ml), while both E1 and E2 levels showed an increase (46 +/- 7 and 30 +/- 8 pg/ml) compared to control subjects (32 +/- 6 and 18 +/- 7 pg/ml). These data suggest that the liver plays an important role on the control of estrogen sulfation.

Metabolic clearance rate of oestrone sulphate in post-menopausal women

Maturitas, 1984

The feasibility of using constant infusions of unlabelled oestrone sulphate (E,S) for the purpose... more The feasibility of using constant infusions of unlabelled oestrone sulphate (E,S) for the purposes of calculating its metabolic clearance rate (MCR,,,) and its conversion ratios to oestrone (Et) and oestradiol (E2) in post-menopausal women was exploited in this study. The results obtained by the infusion of unlabelled E,S were similar to those obtained by the infusion of labelled steroid. The MCR,,, values seen in our group of post-menopausal women fell within the range previously reported for fertile women. The contribution of E,S to circulating E, averaged 18% (range 14-24%) indicating that the E,S-E, equilibrium should be taken into account during studies on oestrogen balance in post-menopausal women.

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P-077 Synchronization of endogenous and exogenous FSH signals for controlled ovarian hyperstimulation (COH)

Fertility and Sterility, 1997

those of the isthmus and ampulla without statistical significance at each menstrual phase. And th... more those of the isthmus and ampulla without statistical significance at each menstrual phase. And there was a decreasing tendency from early follicular to late luteal phase and showed statistical difference in relative IGFBP-6 mRNA expression between early follicular and late luteal phase in the ampullar portion (p<0.05). Conclusion: IGFBP-4, 5, 6 mRNA are expressed in the human fallopian tube. Considering the fact that IGFBP-4 mRNA shows site-dependent differences during the menstrual cycle and relative IGFBP-6 mRNA expressions in the ampullar portion showed menstrual phase-dependent changes, they may modulate the action of IGF by changing their expressions according to the intrafallopian site during menstrual cycle. * Supported by the Samsung grants, #SBRI C-95-017.

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Embryonic Causes of Implantation Failure: A Systematic Review and Procedures To Optimize Successful Embryo Transfer

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Preliminary report on progesterone effect on peripheral estrone sulfate metabolism

V M Jasonni, C Bulletti, F Franceschetti, P Ciotti, M Bonavia, A P Ferraretti, C Flamigni, 1983