International Braz J Urol Official Journal of the Brazilian Society of Urology, Aug 1, 2010
Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary ... more Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary urothelial carcinoma (LG-UrCa) following implementation of the 2004 World Health Organization/International Society of Urological Pathology (WHO/ISUP) consensus classification. To evaluate our cohort of LG-UrCa cases classified according to 2004 WHO/ISUP to reassess outcome and interobserver agreement. Files were searched for all patients diagnosed with LG-UrCa between 1998 and 2008. All sections were reevaluated for accuracy of classification. A total of 112 cases initially diagnosed as LG-UrCa were identified. Of those, 8 of 55 cases (15%) initially diagnosed by nonurologic pathologists were reclassified as high-grade papillary urothelial carcinoma and were excluded. The mean length of follow-up was 40.1 months (range, 2-113 months). Tumor recurrence was encountered in 56 of 104 patients (53.8%), including 37 (35.6%) with LG-UrCa or lower-grade tumors and 19 (18.3%) with high-grade papillary urothelial carcinoma. Of the 19 patients demonstrating grade progression, 7 (37%) also developed stage progression (invasive carcinoma, n = 5; metastatic carcinoma, n = 2). Seven patients eventually underwent radical cystectomy. None of the 104 patients died of bladder cancer. The mean number of recurrence episodes was 3.11. The mean durations of time to first recurrence and time to grade progression were 13.9 months and 25.1 months, respectively. The mean size of initial tumors was 1.73 cm. There was no significant correlation between tumor size, patient age, sex, or smoking history and the likelihood for recurrence or grade progression. A significantly higher rate of recurrence was seen in patients with multiple tumors at initial diagnosis (P = .04). A tendency to underdiagnose high-grade papillary urothelial carcinoma continues to exist. More than half (53.8%) of patients with LG-UrCa developed recurrence, with an 18.3% incidence of grade progression and a 6.7% incidence of stage progression. Patients with multiple initial tumors had significantly higher risk of developing recurrence.
Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural c... more Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural changes in the brain. Functional changes associated to neurological disorders can be figured out by positron emission tomography (PET) as it allows to study the activation of certain areas of the brain during specific task development. On the other hand, neurological disorders can also be discovered by analysing structural changes in the brain which are usually assessed by Magnetic Resonance Imaging (MRI). In fact, computer-aided diagnosis tools (CAD) that have been recently devised for the diagnosis of neurological disorders use functional or structural data. However, functional and structural data can be fused out in order to improve the accuracy and to diminish the false positive rate in CAD tools. In this paper we present a method for the diagnosis of AD which fuses multimodal image (PET and MRI) data by combining Sparse Representation Classifiers (SRC). The method presented in this w...
A novel porin, OmpG, is produced in response to a chromosomal mutation termed cog-192. Molecular ... more A novel porin, OmpG, is produced in response to a chromosomal mutation termed cog-192. Molecular characterization of cog-192 revealed that it is a large chromosomal deletion extending from the 3' end of pspA through to the 5' end of an open reading frame located immediately upstream of ompG. As a result of this 13.1-kb deletion, the expression of ompG was placed under the control of the pspA promoter. Characterization of OmpG revealed that it is quite different from other porins. Proteoliposome swelling assays showed that OmpG channels were much larger than those of the OmpF and OmpC porins, with an estimated limited diameter of about 2 nm. The channel lacked any obvious solute specificity. The folding model of OmpG suggests that it is the first 16-stranded beta-barrel porin that lacks the large external loop, L3, which constricts the channels of other nonspecific and specific porins. Consistent with the folding model, circular dichroism showed that OmpG contains largely a b...
... Felicia L. Wilczenski, Beth Sulzer-Azaroff, and Robert S. Feldman University of Massachusetts... more ... Felicia L. Wilczenski, Beth Sulzer-Azaroff, and Robert S. Feldman University of Massachusetts, Amherst Daniel E. Fajardo Amherst Public Schools ... In this consultative role, the psychologist would collaborate with teachers (Lambert, 1974) in dealing with a variety of instructional ...
Studies in health technology and informatics, 2014
Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural c... more Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural changes in the brain. Functional changes associated to neurological disorders can be figured out by positron emission tomography (PET) as it allows to study the activation of certain areas of the brain during specific task development. On the other hand, neurological disorders can also be discovered by analysing structural changes in the brain which are usually assessed by Magnetic Resonance Imaging (MRI). In fact, computer-aided diagnosis tools (CAD) that have been recently devised for the diagnosis of neurological disorders use functional or structural data. However, functional and structural data can be fused out in order to improve the accuracy and to diminish the false positive rate in CAD tools. In this paper we present a method for the diagnosis of AD which fuses multimodal image (PET and MRI) data by combining Sparse Representation Classifiers (SRC). The method presented in this w...
Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary ... more Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary urothelial carcinoma (LG-UrCa) following implementation of the 2004 World Health Organization/International Society of Urological Pathology (WHO/ISUP) consensus classification. To evaluate our cohort of LG-UrCa cases classified according to 2004 WHO/ISUP to reassess outcome and interobserver agreement. Files were searched for all patients diagnosed with LG-UrCa between 1998 and 2008. All sections were reevaluated for accuracy of classification. A total of 112 cases initially diagnosed as LG-UrCa were identified. Of those, 8 of 55 cases (15%) initially diagnosed by nonurologic pathologists were reclassified as high-grade papillary urothelial carcinoma and were excluded. The mean length of follow-up was 40.1 months (range, 2-113 months). Tumor recurrence was encountered in 56 of 104 patients (53.8%), including 37 (35.6%) with LG-UrCa or lower-grade tumors and 19 (18.3%) with high-grade pap...
About one half of all bladder neoplasms are noninvasive, and in those, the histologic grade is a ... more About one half of all bladder neoplasms are noninvasive, and in those, the histologic grade is a crucial prognosticator. Few single-center studies have assessed the recurrence, progression, and cancer-related mortality rates of noninvasive high-grade papillary urothelial carcinomas. With this aim, we evaluated the clinicopathologic and outcome features of 85 patients with high-grade papillary urothelial carcinoma. Median age was 68 years, and 80.5% were men. Tumor size ranged from 0.3 to 13.0 cm (median, 1.6 cm). Recurrence was found in 36.5% of the patients, whereas tumor progression, defined as invasion of lamina propria or beyond, was identified in 40% of all cases. When present, lesion reappearance involved mostly 1 to 2 episodes. Metastasis appeared in 20% of the patients, and 15% died of disseminated bladder cancer. All cancer-related deaths occurred in the group of patients with progression, whereas patients with recurrence showed similar outcomes to those with no recurrence....
The classification and grading of papillary urothelial neoplasms has been a long-standing subject... more The classification and grading of papillary urothelial neoplasms has been a long-standing subject of controversy. Previously, numerous diverse grading schemes for bladder tumor, including the 1973 World Health Organization (WHO) classification, existed whereby one of the major limitations was poor inter-observer reproducibility among pathologists. The WHO/International Society of Urological Pathology (ISUP) consensus classification system of urothelial neoplasms of the urinary bladder was developed in 1998 and was revised most recently in 2003 (published in 2004). Importantly, the current classification system provides detailed histological criteria for papillary urothelial lesions and allows for designation of a lesion (papillary urothelial neoplasm of low malignant potential) with a negligible risk of progression. Thus, the latest system is designed to be a universally acceptable one for bladder tumors that not only could be effectively used by pathologists, urologists, and oncologists, but also stratifies the tumors into prognostically significant categories. This article outlines the 2004 WHO/ISUP classification system regarding the specific histological criteria for non-invasive papillary urothelial neoplasms and the clinical significance of each category.
International Braz J Urol Official Journal of the Brazilian Society of Urology, Aug 1, 2010
Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary ... more Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary urothelial carcinoma (LG-UrCa) following implementation of the 2004 World Health Organization/International Society of Urological Pathology (WHO/ISUP) consensus classification. To evaluate our cohort of LG-UrCa cases classified according to 2004 WHO/ISUP to reassess outcome and interobserver agreement. Files were searched for all patients diagnosed with LG-UrCa between 1998 and 2008. All sections were reevaluated for accuracy of classification. A total of 112 cases initially diagnosed as LG-UrCa were identified. Of those, 8 of 55 cases (15%) initially diagnosed by nonurologic pathologists were reclassified as high-grade papillary urothelial carcinoma and were excluded. The mean length of follow-up was 40.1 months (range, 2-113 months). Tumor recurrence was encountered in 56 of 104 patients (53.8%), including 37 (35.6%) with LG-UrCa or lower-grade tumors and 19 (18.3%) with high-grade papillary urothelial carcinoma. Of the 19 patients demonstrating grade progression, 7 (37%) also developed stage progression (invasive carcinoma, n = 5; metastatic carcinoma, n = 2). Seven patients eventually underwent radical cystectomy. None of the 104 patients died of bladder cancer. The mean number of recurrence episodes was 3.11. The mean durations of time to first recurrence and time to grade progression were 13.9 months and 25.1 months, respectively. The mean size of initial tumors was 1.73 cm. There was no significant correlation between tumor size, patient age, sex, or smoking history and the likelihood for recurrence or grade progression. A significantly higher rate of recurrence was seen in patients with multiple tumors at initial diagnosis (P = .04). A tendency to underdiagnose high-grade papillary urothelial carcinoma continues to exist. More than half (53.8%) of patients with LG-UrCa developed recurrence, with an 18.3% incidence of grade progression and a 6.7% incidence of stage progression. Patients with multiple initial tumors had significantly higher risk of developing recurrence.
Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural c... more Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural changes in the brain. Functional changes associated to neurological disorders can be figured out by positron emission tomography (PET) as it allows to study the activation of certain areas of the brain during specific task development. On the other hand, neurological disorders can also be discovered by analysing structural changes in the brain which are usually assessed by Magnetic Resonance Imaging (MRI). In fact, computer-aided diagnosis tools (CAD) that have been recently devised for the diagnosis of neurological disorders use functional or structural data. However, functional and structural data can be fused out in order to improve the accuracy and to diminish the false positive rate in CAD tools. In this paper we present a method for the diagnosis of AD which fuses multimodal image (PET and MRI) data by combining Sparse Representation Classifiers (SRC). The method presented in this w...
A novel porin, OmpG, is produced in response to a chromosomal mutation termed cog-192. Molecular ... more A novel porin, OmpG, is produced in response to a chromosomal mutation termed cog-192. Molecular characterization of cog-192 revealed that it is a large chromosomal deletion extending from the 3' end of pspA through to the 5' end of an open reading frame located immediately upstream of ompG. As a result of this 13.1-kb deletion, the expression of ompG was placed under the control of the pspA promoter. Characterization of OmpG revealed that it is quite different from other porins. Proteoliposome swelling assays showed that OmpG channels were much larger than those of the OmpF and OmpC porins, with an estimated limited diameter of about 2 nm. The channel lacked any obvious solute specificity. The folding model of OmpG suggests that it is the first 16-stranded beta-barrel porin that lacks the large external loop, L3, which constricts the channels of other nonspecific and specific porins. Consistent with the folding model, circular dichroism showed that OmpG contains largely a b...
... Felicia L. Wilczenski, Beth Sulzer-Azaroff, and Robert S. Feldman University of Massachusetts... more ... Felicia L. Wilczenski, Beth Sulzer-Azaroff, and Robert S. Feldman University of Massachusetts, Amherst Daniel E. Fajardo Amherst Public Schools ... In this consultative role, the psychologist would collaborate with teachers (Lambert, 1974) in dealing with a variety of instructional ...
Studies in health technology and informatics, 2014
Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural c... more Alzheimer's Diasese (AD) diagnosis can be carried out by analysing functional or structural changes in the brain. Functional changes associated to neurological disorders can be figured out by positron emission tomography (PET) as it allows to study the activation of certain areas of the brain during specific task development. On the other hand, neurological disorders can also be discovered by analysing structural changes in the brain which are usually assessed by Magnetic Resonance Imaging (MRI). In fact, computer-aided diagnosis tools (CAD) that have been recently devised for the diagnosis of neurological disorders use functional or structural data. However, functional and structural data can be fused out in order to improve the accuracy and to diminish the false positive rate in CAD tools. In this paper we present a method for the diagnosis of AD which fuses multimodal image (PET and MRI) data by combining Sparse Representation Classifiers (SRC). The method presented in this w...
Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary ... more Few large cohort studies have addressed outcome in patients with noninvasive low-grade papillary urothelial carcinoma (LG-UrCa) following implementation of the 2004 World Health Organization/International Society of Urological Pathology (WHO/ISUP) consensus classification. To evaluate our cohort of LG-UrCa cases classified according to 2004 WHO/ISUP to reassess outcome and interobserver agreement. Files were searched for all patients diagnosed with LG-UrCa between 1998 and 2008. All sections were reevaluated for accuracy of classification. A total of 112 cases initially diagnosed as LG-UrCa were identified. Of those, 8 of 55 cases (15%) initially diagnosed by nonurologic pathologists were reclassified as high-grade papillary urothelial carcinoma and were excluded. The mean length of follow-up was 40.1 months (range, 2-113 months). Tumor recurrence was encountered in 56 of 104 patients (53.8%), including 37 (35.6%) with LG-UrCa or lower-grade tumors and 19 (18.3%) with high-grade pap...
About one half of all bladder neoplasms are noninvasive, and in those, the histologic grade is a ... more About one half of all bladder neoplasms are noninvasive, and in those, the histologic grade is a crucial prognosticator. Few single-center studies have assessed the recurrence, progression, and cancer-related mortality rates of noninvasive high-grade papillary urothelial carcinomas. With this aim, we evaluated the clinicopathologic and outcome features of 85 patients with high-grade papillary urothelial carcinoma. Median age was 68 years, and 80.5% were men. Tumor size ranged from 0.3 to 13.0 cm (median, 1.6 cm). Recurrence was found in 36.5% of the patients, whereas tumor progression, defined as invasion of lamina propria or beyond, was identified in 40% of all cases. When present, lesion reappearance involved mostly 1 to 2 episodes. Metastasis appeared in 20% of the patients, and 15% died of disseminated bladder cancer. All cancer-related deaths occurred in the group of patients with progression, whereas patients with recurrence showed similar outcomes to those with no recurrence....
The classification and grading of papillary urothelial neoplasms has been a long-standing subject... more The classification and grading of papillary urothelial neoplasms has been a long-standing subject of controversy. Previously, numerous diverse grading schemes for bladder tumor, including the 1973 World Health Organization (WHO) classification, existed whereby one of the major limitations was poor inter-observer reproducibility among pathologists. The WHO/International Society of Urological Pathology (ISUP) consensus classification system of urothelial neoplasms of the urinary bladder was developed in 1998 and was revised most recently in 2003 (published in 2004). Importantly, the current classification system provides detailed histological criteria for papillary urothelial lesions and allows for designation of a lesion (papillary urothelial neoplasm of low malignant potential) with a negligible risk of progression. Thus, the latest system is designed to be a universally acceptable one for bladder tumors that not only could be effectively used by pathologists, urologists, and oncologists, but also stratifies the tumors into prognostically significant categories. This article outlines the 2004 WHO/ISUP classification system regarding the specific histological criteria for non-invasive papillary urothelial neoplasms and the clinical significance of each category.
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