Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unid... more Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unidimensional chromatography to separate them is inefficient and insensitive. This has sparked the invention of several linked chromatography methods, each of them with distinct separation principles and affinity for the analyte of interest. Multidimensional chromatography consists of the combination of multiple chromatography techniques, with great benefits at the level of efficiency, peak capacity, precision, and accuracy of the analysis, while reducing the time required for the analysis. Various coupled chromatography techniques have recently emerged, including liquid chromatography–gas chromatography (LC–GC), gas chromatography–gas chromatography (GC–GC), liquid chromatography–liquid chromatography (LC–LC), GCMS–MS, LCMS–MS, supercritical fluid techniques with chromatography techniques, and electro-driven multidimensional separation techniques. In this paper, the different coupled chrom...
Journal of Pharmaceutical Research International, 2021
The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substit... more The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substituted theophylline derivatives (3A-3D), followed by ammonium thiocyanate and substituted aromatic aldehyde, and these synthesized derivatives were screened to study their analgesic and anti-inflammatory activities. UV, IR, H-1 NMR, mass spectral data, and CHN activities were used to describe the compounds, which were shown to be considerably efficacious at 100 mg/kg p.o., as well as experimental results that were statistically significant at the p <0.01 and p <0.05 levels.
Journal of Pharmaceutical Research International, 2021
The purpose of this research is to assess the anti-diabetic effects of several medicinal herbs. H... more The purpose of this research is to assess the anti-diabetic effects of several medicinal herbs. Herbal medicine has grown in popularity in both developing and developed countries over the last several years, owing to its natural origins and lack of negative effects. Even though medicinal plants have been utilized to treat diabetes mellitus from ancient times, they have been offered as abundant but untapped prospective sources for anti-diabetic medicines. It's a reality that diabetes can't be cured, and no one has ever claimed to be completely free of the disease. Diabetes mellitus is becoming a severe hazard to human health in all regions of the world due to its fast growing occurrence. Furthermore, several novel bioactive compounds derived from plants have demonstrated antidiabetic action with greater efficacy than oral hypoglycemic medicines already utilized in clinical therapy in recent years. Despite the fact that many plants are recommended, further pharmacological and ...
A few five members’ aromatic systems having three hetero-atoms at symmetrical positions, for exam... more A few five members’ aromatic systems having three hetero-atoms at symmetrical positions, for example, thiadiazoles have been considered broadly attributable to their intriguing pharmacological properties. These thiadiazole derivatives are the heterocyclic compound which contains the five member ring along with nitrogen and sulfur atoms. This recent study covers the most dynamic thiadiazole subordinates that have demonstrated significant biological activities, for example, anti microbial, anti inflammatory, anti tubercular, ant-diabetic, diuretics, anti depressant, radio-protective, anti-leishmanial and cytotoxic activity. This review likewise examines the structure-activity relationship (SAR) of the most powerful compounds. It can go about as an imperative tool for restorative scientists to create more current compounds having thiadiazole moiety that could be better operators regarding viability and safety.
Objective: Thiadiazole derivatives were reported to have wide range of biological activities. Hen... more Objective: Thiadiazole derivatives were reported to have wide range of biological activities. Hence present work was planned to synthesize thiadiazole derivatives and screen for their analgesic, antipyretic and anti-inflammatory. Methods: Thiosemicarbazide was made to react with aryl carboxylic acid in presence of concentrated sulphuric acid to form 5-(substituted phenyl)-2-amino -1, 3, 4-thiadiazole. To aromatic amines, chloroacetyl chloride was added drop wise in presence of glacial acetic acid and saturated solution of sodium acetate to form 2chloro-N-substituted-phenyl-acetamide. This acetamide compound was reacted with 5-(substituted phenyl)-2-amino -1, 3, 4-thiadiazole in 1, 4dioxane and triethylamine (TEA), refluxed for 3 hrs to form N(substuted-phenyl)-2-[5-(3-substituted-phenyl)-1, 3, 4-thiadiazol-2-yl amino]-acetamide. Characterization of all the compounds was performed by IR, 1 HNMR, Mass spectroscopic and elemental analysis. Results: The compounds IIIA10, VA17, 2b and 3b...
Erectile dysfunction in young fellows is an inexorably regular boss grumbling found in urology ce... more Erectile dysfunction in young fellows is an inexorably regular boss grumbling found in urology centers over the world. The worldwide urologic network has taken an expanded enthusiasm for this subject, with specialists in the field of andrology and sexual dysfunction distributing numerous survey articles. An American Urological Association Updated Series Lesson devoted to this concerning issue. These books skillfully address the study of disease transmission and analytic assessment of erectile dysfunction (ED) and order ED into psychogenic or natural causes, tending to treatment choices with explicit intercessions for every one of the most widely recognized determinations. It is to be utilized everywhere throughout the nation since this book is a one of a kind mix of straight forwardness, educational and precision. This release additionally shows the realities of sexual capacity and dysfunction so the expert can appropriately treat essential issues with effectively endorsed treatments.
The various derivatives of thiadiazole were prepared by the reaction of 2-chloro-N-[5-(2-hydroxyp... more The various derivatives of thiadiazole were prepared by the reaction of 2-chloro-N-[5-(2-hydroxyphenyl)-1, 3, 4-thiadiazol-2-yl]-acetamide, 2-chloro-N-[5-(4-chlorophenyl)-1, 3, 4-thiadiazol-2-yl]-acetamide, 2-chloro-N-[5(2-nitrophenyl)-1,3,4-thiadiazol-2-yl]-acetamide with thiourea /hydrazine hydrate / piperidine in dry alcohol. Elemental analysis, IR, 1 H NMR, mass spectral data confirmed the structure of the newly synthesized compounds. All the derivatives of these moieties were evaluated for in-vitro antimicrobial activity. Most of the synthesized compounds showed potent antimicrobial activity at 100 and 50 μg/ml. Compounds showed most significant antibacterial activity against gram positive test organism B. subtilis and most significant antifungal activity against test organisms C. albicans. Keyword: Synthesis; Aryl carboxylic acid; Thiosemicarbazide; 1, 3, 4-Thiadiazole; Chloroacetylation; Antimicrobial activity
Background: Childhood dental caries is a significant wellbeing worry in kids that keep on contrar... more Background: Childhood dental caries is a significant wellbeing worry in kids that keep on contrarily influence the oral wellbeing. Oral wellbeing in children’s assumes a key job as it sets out the establishment for sound lasting teeth. This investigation was done to evaluate the mindfulness level of guardians about the children's oral health. Methods: A cross-sectional survey study was directed among 150 guardians with children’s' answering to private dental school. In this examination, the guardians of kids’ children than 5–15 years were approached to fill the pre-tried questioner directed survey and the information were classified. Results: It was seen that constrained members knew about the oral soundness of preschool children. About 34% of guardians have information identified with brushing procedures and oral maladies. Just 36% of guardians have general mindfulness identified with children's oral wellbeing, significance of standard dental exam, and investigation of ...
Several pharmacological activities like antitubercular, analgesic, anti-cancer, anti-inflammatory... more Several pharmacological activities like antitubercular, analgesic, anti-cancer, anti-inflammatory, antiasthmatic, antioxidant and antibacterial activities have been attributed to pyrazoles and pyrazoline derivatives. The above observations prompted us to synthesize some novel pyrazoline derivatives as possible antimicrobial agents. A series of novel substituted pyrazoline derivatives (7a-7g and 8a-8g) have been synthesized by the reaction of [6benzylidene-3-phenyl-3a, 4, 5, 6- tetrahydrocyclopenta [c] pyrazol-2(3H)-yl] acetylchloride(5), 2-[6-(4methoxybenzylidene)-3-(4-methoxyphenyl) 3a, 4 , 5 , 6-tetrahydrocyclopenta [c]pyrazol-2(3H)-yl] acetylchloride(6) with substituted aryl/alkyl amine in the presence of formaldehyde. The starting material, chalcones were prepared by claisen Schmidt condensation of cyclopentanone with aldehydes/substituted aldehyde in the presence of sodium hydroxide in ethanol. The cycloaddition of chalcones with hydrazine hydrochlored gives substituted pyrazol...
Journal of Pharmaceutical Research International, 2022
Background: Inflammation is a major condition associated with various diseases. Osbeckia crinita ... more Background: Inflammation is a major condition associated with various diseases. Osbeckia crinita (Family- Melastomataceae) plants found in Meghalaya has the traditional beliefs to treat in the various disorders including various inflammatory disorders. Objective: Evaluate the antioxidant and anti inflammatory activities of the leaves of Osbeckia crinita. Methods: DPPH Radical Scavenging Activity and Carrageenan induced paw edema in mice. Results: In the plant extract, various phytoconstituents are present including flavonoids, glycosides, alkaloids etc. Methanolic extract of Osbeckia crinita prominently showed free radical scavenging activities. The extract exhibited statistically significant inhibition of paw volume in a dose-dependent manner. Conclusion: The study highlights the efficacy of Osbeckia crinita which is an ancient tradition, used in North eastern part of India. This ancient concept should be carefully evaluated in the light of modern medical science and can be utilize...
Ulcer is an open sore or an outer or inner surface of the body brought about by ... more Ulcer is an open sore or an outer or inner surface of the body brought about by a break in the skin or mucus membrane usually, a blood stream issue which neglects to mend. Ulcer ranges from little excruciating wounds in the mouth to bedsores and genuine sores of the stomach or digestive tract. Ulceration happens when there is an unsettling influence of the ordinary harmony brought about by either upgraded animosity or reduced mucosal resistance. It might be because of the ordinary use of medications, sporadic sustenance propensities, stress, thus forth. Ulcers can likewise be brought about by an infection, called H. pylori. Regular indications of gastric ulcers incorporate weight reduction, poor hunger, swelling, burping, spewing and once in a while heaving blood. The present review focuses on history of ulcer, its types, pathophysiology, anti-ulcer therapeutic plants and current st...
Aim: The present study was aimed to establish antifungal activity of flavonoid isolated from Lind... more Aim: The present study was aimed to establish antifungal activity of flavonoid isolated from Lindernia crustacea (L) F. Muell. Methods: Potent bioactive constituent from benzene extract was isolated through flash chromatography with solvent Toluene and Acetic acid (4:1). Isolated compound was structurally established by spectroscopic method. Antifungal potential of benzene extract as well as isolated compound was tested by disc diffusion method against two fungal strains Candida albicans (C. albicans) and Trichophyton rubrum (T. rubrum). Results: The isolated compound from benzene extract was found to be flavonoid. Benzene extract as well as flavonoid were shown remarkable zone of inhibition against both fungal strains which indicates strong antifungal activity. Conclusion: The experimental results concluded that Lindernia crustacea (L) F. Muell have significant anti fungal activity due to flavonoid content. It is expected that the results of the present research work would be benef...
Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drug...
Co‑crystal chemistry has recently attracted supramolecular scientists. Co-crystals are comprising... more Co‑crystal chemistry has recently attracted supramolecular scientists. Co-crystals are comprising of hydrogen bonding assembly between different molecules. Many issues related to the performance characteristics of an active pharmaceutical ingredient (API) can be resolved using the co-crystallization approach. A proper understanding of the crystal structure of an API is required for the successful formation of co-crystals with the selected co‑former. Co-crystal chemistry has recently attracted scientists from the super molecules. Co crystals consist of the assembly of hydrogen bonds between various molecules. Many problems related to the performance characteristics of an active pharmaceutical ingredient (API) can be solved using the method of co-crystallization. Co-Crystals offer an alternate pathway where any API, paying little mind to be acidic, essential, or ionizable gatherings, might be co-gem. This aspect also helps to complement existing methods by reintroducing molecules with...
Natural plants various metabolites are widely utilized in a different kind of infections and infl... more Natural plants various metabolites are widely utilized in a different kind of infections and inflammation as traditional medication. The inflammatory response is a reaction always effects in daily life and physical issue and activity of herbal complex act through of blood vessels. Inflammation is a pathologic issue that incorporates a wide scope of sicknesses, for example rheumatic, diabetes, cardiovascular accident and chronic kidney disease. We present a few herbal spices which their metabolites that have been assessed in clinical and test. The review includes number of various herbal plants with their families, parts utilized, k concentrate utilized, bioassay models and their usages in medicinal activities.
Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unid... more Food, drugs, dyes, extracts, and minerals are all made up of complex elements, and utilizing unidimensional chromatography to separate them is inefficient and insensitive. This has sparked the invention of several linked chromatography methods, each of them with distinct separation principles and affinity for the analyte of interest. Multidimensional chromatography consists of the combination of multiple chromatography techniques, with great benefits at the level of efficiency, peak capacity, precision, and accuracy of the analysis, while reducing the time required for the analysis. Various coupled chromatography techniques have recently emerged, including liquid chromatography–gas chromatography (LC–GC), gas chromatography–gas chromatography (GC–GC), liquid chromatography–liquid chromatography (LC–LC), GCMS–MS, LCMS–MS, supercritical fluid techniques with chromatography techniques, and electro-driven multidimensional separation techniques. In this paper, the different coupled chrom...
Journal of Pharmaceutical Research International, 2021
The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substit... more The reaction of theophylline and chloro-acetyl chloride produced an exceptional series of substituted theophylline derivatives (3A-3D), followed by ammonium thiocyanate and substituted aromatic aldehyde, and these synthesized derivatives were screened to study their analgesic and anti-inflammatory activities. UV, IR, H-1 NMR, mass spectral data, and CHN activities were used to describe the compounds, which were shown to be considerably efficacious at 100 mg/kg p.o., as well as experimental results that were statistically significant at the p <0.01 and p <0.05 levels.
Journal of Pharmaceutical Research International, 2021
The purpose of this research is to assess the anti-diabetic effects of several medicinal herbs. H... more The purpose of this research is to assess the anti-diabetic effects of several medicinal herbs. Herbal medicine has grown in popularity in both developing and developed countries over the last several years, owing to its natural origins and lack of negative effects. Even though medicinal plants have been utilized to treat diabetes mellitus from ancient times, they have been offered as abundant but untapped prospective sources for anti-diabetic medicines. It's a reality that diabetes can't be cured, and no one has ever claimed to be completely free of the disease. Diabetes mellitus is becoming a severe hazard to human health in all regions of the world due to its fast growing occurrence. Furthermore, several novel bioactive compounds derived from plants have demonstrated antidiabetic action with greater efficacy than oral hypoglycemic medicines already utilized in clinical therapy in recent years. Despite the fact that many plants are recommended, further pharmacological and ...
A few five members’ aromatic systems having three hetero-atoms at symmetrical positions, for exam... more A few five members’ aromatic systems having three hetero-atoms at symmetrical positions, for example, thiadiazoles have been considered broadly attributable to their intriguing pharmacological properties. These thiadiazole derivatives are the heterocyclic compound which contains the five member ring along with nitrogen and sulfur atoms. This recent study covers the most dynamic thiadiazole subordinates that have demonstrated significant biological activities, for example, anti microbial, anti inflammatory, anti tubercular, ant-diabetic, diuretics, anti depressant, radio-protective, anti-leishmanial and cytotoxic activity. This review likewise examines the structure-activity relationship (SAR) of the most powerful compounds. It can go about as an imperative tool for restorative scientists to create more current compounds having thiadiazole moiety that could be better operators regarding viability and safety.
Objective: Thiadiazole derivatives were reported to have wide range of biological activities. Hen... more Objective: Thiadiazole derivatives were reported to have wide range of biological activities. Hence present work was planned to synthesize thiadiazole derivatives and screen for their analgesic, antipyretic and anti-inflammatory. Methods: Thiosemicarbazide was made to react with aryl carboxylic acid in presence of concentrated sulphuric acid to form 5-(substituted phenyl)-2-amino -1, 3, 4-thiadiazole. To aromatic amines, chloroacetyl chloride was added drop wise in presence of glacial acetic acid and saturated solution of sodium acetate to form 2chloro-N-substituted-phenyl-acetamide. This acetamide compound was reacted with 5-(substituted phenyl)-2-amino -1, 3, 4-thiadiazole in 1, 4dioxane and triethylamine (TEA), refluxed for 3 hrs to form N(substuted-phenyl)-2-[5-(3-substituted-phenyl)-1, 3, 4-thiadiazol-2-yl amino]-acetamide. Characterization of all the compounds was performed by IR, 1 HNMR, Mass spectroscopic and elemental analysis. Results: The compounds IIIA10, VA17, 2b and 3b...
Erectile dysfunction in young fellows is an inexorably regular boss grumbling found in urology ce... more Erectile dysfunction in young fellows is an inexorably regular boss grumbling found in urology centers over the world. The worldwide urologic network has taken an expanded enthusiasm for this subject, with specialists in the field of andrology and sexual dysfunction distributing numerous survey articles. An American Urological Association Updated Series Lesson devoted to this concerning issue. These books skillfully address the study of disease transmission and analytic assessment of erectile dysfunction (ED) and order ED into psychogenic or natural causes, tending to treatment choices with explicit intercessions for every one of the most widely recognized determinations. It is to be utilized everywhere throughout the nation since this book is a one of a kind mix of straight forwardness, educational and precision. This release additionally shows the realities of sexual capacity and dysfunction so the expert can appropriately treat essential issues with effectively endorsed treatments.
The various derivatives of thiadiazole were prepared by the reaction of 2-chloro-N-[5-(2-hydroxyp... more The various derivatives of thiadiazole were prepared by the reaction of 2-chloro-N-[5-(2-hydroxyphenyl)-1, 3, 4-thiadiazol-2-yl]-acetamide, 2-chloro-N-[5-(4-chlorophenyl)-1, 3, 4-thiadiazol-2-yl]-acetamide, 2-chloro-N-[5(2-nitrophenyl)-1,3,4-thiadiazol-2-yl]-acetamide with thiourea /hydrazine hydrate / piperidine in dry alcohol. Elemental analysis, IR, 1 H NMR, mass spectral data confirmed the structure of the newly synthesized compounds. All the derivatives of these moieties were evaluated for in-vitro antimicrobial activity. Most of the synthesized compounds showed potent antimicrobial activity at 100 and 50 μg/ml. Compounds showed most significant antibacterial activity against gram positive test organism B. subtilis and most significant antifungal activity against test organisms C. albicans. Keyword: Synthesis; Aryl carboxylic acid; Thiosemicarbazide; 1, 3, 4-Thiadiazole; Chloroacetylation; Antimicrobial activity
Background: Childhood dental caries is a significant wellbeing worry in kids that keep on contrar... more Background: Childhood dental caries is a significant wellbeing worry in kids that keep on contrarily influence the oral wellbeing. Oral wellbeing in children’s assumes a key job as it sets out the establishment for sound lasting teeth. This investigation was done to evaluate the mindfulness level of guardians about the children's oral health. Methods: A cross-sectional survey study was directed among 150 guardians with children’s' answering to private dental school. In this examination, the guardians of kids’ children than 5–15 years were approached to fill the pre-tried questioner directed survey and the information were classified. Results: It was seen that constrained members knew about the oral soundness of preschool children. About 34% of guardians have information identified with brushing procedures and oral maladies. Just 36% of guardians have general mindfulness identified with children's oral wellbeing, significance of standard dental exam, and investigation of ...
Several pharmacological activities like antitubercular, analgesic, anti-cancer, anti-inflammatory... more Several pharmacological activities like antitubercular, analgesic, anti-cancer, anti-inflammatory, antiasthmatic, antioxidant and antibacterial activities have been attributed to pyrazoles and pyrazoline derivatives. The above observations prompted us to synthesize some novel pyrazoline derivatives as possible antimicrobial agents. A series of novel substituted pyrazoline derivatives (7a-7g and 8a-8g) have been synthesized by the reaction of [6benzylidene-3-phenyl-3a, 4, 5, 6- tetrahydrocyclopenta [c] pyrazol-2(3H)-yl] acetylchloride(5), 2-[6-(4methoxybenzylidene)-3-(4-methoxyphenyl) 3a, 4 , 5 , 6-tetrahydrocyclopenta [c]pyrazol-2(3H)-yl] acetylchloride(6) with substituted aryl/alkyl amine in the presence of formaldehyde. The starting material, chalcones were prepared by claisen Schmidt condensation of cyclopentanone with aldehydes/substituted aldehyde in the presence of sodium hydroxide in ethanol. The cycloaddition of chalcones with hydrazine hydrochlored gives substituted pyrazol...
Journal of Pharmaceutical Research International, 2022
Background: Inflammation is a major condition associated with various diseases. Osbeckia crinita ... more Background: Inflammation is a major condition associated with various diseases. Osbeckia crinita (Family- Melastomataceae) plants found in Meghalaya has the traditional beliefs to treat in the various disorders including various inflammatory disorders. Objective: Evaluate the antioxidant and anti inflammatory activities of the leaves of Osbeckia crinita. Methods: DPPH Radical Scavenging Activity and Carrageenan induced paw edema in mice. Results: In the plant extract, various phytoconstituents are present including flavonoids, glycosides, alkaloids etc. Methanolic extract of Osbeckia crinita prominently showed free radical scavenging activities. The extract exhibited statistically significant inhibition of paw volume in a dose-dependent manner. Conclusion: The study highlights the efficacy of Osbeckia crinita which is an ancient tradition, used in North eastern part of India. This ancient concept should be carefully evaluated in the light of modern medical science and can be utilize...
Ulcer is an open sore or an outer or inner surface of the body brought about by ... more Ulcer is an open sore or an outer or inner surface of the body brought about by a break in the skin or mucus membrane usually, a blood stream issue which neglects to mend. Ulcer ranges from little excruciating wounds in the mouth to bedsores and genuine sores of the stomach or digestive tract. Ulceration happens when there is an unsettling influence of the ordinary harmony brought about by either upgraded animosity or reduced mucosal resistance. It might be because of the ordinary use of medications, sporadic sustenance propensities, stress, thus forth. Ulcers can likewise be brought about by an infection, called H. pylori. Regular indications of gastric ulcers incorporate weight reduction, poor hunger, swelling, burping, spewing and once in a while heaving blood. The present review focuses on history of ulcer, its types, pathophysiology, anti-ulcer therapeutic plants and current st...
Aim: The present study was aimed to establish antifungal activity of flavonoid isolated from Lind... more Aim: The present study was aimed to establish antifungal activity of flavonoid isolated from Lindernia crustacea (L) F. Muell. Methods: Potent bioactive constituent from benzene extract was isolated through flash chromatography with solvent Toluene and Acetic acid (4:1). Isolated compound was structurally established by spectroscopic method. Antifungal potential of benzene extract as well as isolated compound was tested by disc diffusion method against two fungal strains Candida albicans (C. albicans) and Trichophyton rubrum (T. rubrum). Results: The isolated compound from benzene extract was found to be flavonoid. Benzene extract as well as flavonoid were shown remarkable zone of inhibition against both fungal strains which indicates strong antifungal activity. Conclusion: The experimental results concluded that Lindernia crustacea (L) F. Muell have significant anti fungal activity due to flavonoid content. It is expected that the results of the present research work would be benef...
Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a s... more Objective: Shortages of medicinal products are complex global problems. Drug shortages remain a significant public health issue. Global shortages of medical products have a potential effect on patient health and total healthcare costs. Countries worldwide, especially those affected by Coronavirus disease 2019 (COVID-19), is experiencing a rapid increase in drug shortage, which causes several complications for physicians, health care provider, patients, health institutes and health regulatory bodies. Methods: To carry out the study of shortages, several efforts have been taken by the regulators and industries. Prominent amongst these include FDA's research the needs and the reforms made in the regulations about shortages. We also searched for electronic databases (PubMed, Science direct, Web of Science) using the terms (COVID-19 and shortage) or (medicine and COVID-19) for articles in periods of 2019 to 2021. Results: On assessment based on the report, the number of shortage drug...
Co‑crystal chemistry has recently attracted supramolecular scientists. Co-crystals are comprising... more Co‑crystal chemistry has recently attracted supramolecular scientists. Co-crystals are comprising of hydrogen bonding assembly between different molecules. Many issues related to the performance characteristics of an active pharmaceutical ingredient (API) can be resolved using the co-crystallization approach. A proper understanding of the crystal structure of an API is required for the successful formation of co-crystals with the selected co‑former. Co-crystal chemistry has recently attracted scientists from the super molecules. Co crystals consist of the assembly of hydrogen bonds between various molecules. Many problems related to the performance characteristics of an active pharmaceutical ingredient (API) can be solved using the method of co-crystallization. Co-Crystals offer an alternate pathway where any API, paying little mind to be acidic, essential, or ionizable gatherings, might be co-gem. This aspect also helps to complement existing methods by reintroducing molecules with...
Natural plants various metabolites are widely utilized in a different kind of infections and infl... more Natural plants various metabolites are widely utilized in a different kind of infections and inflammation as traditional medication. The inflammatory response is a reaction always effects in daily life and physical issue and activity of herbal complex act through of blood vessels. Inflammation is a pathologic issue that incorporates a wide scope of sicknesses, for example rheumatic, diabetes, cardiovascular accident and chronic kidney disease. We present a few herbal spices which their metabolites that have been assessed in clinical and test. The review includes number of various herbal plants with their families, parts utilized, k concentrate utilized, bioassay models and their usages in medicinal activities.
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Papers by Dr.Faruk Alam