Abstract: The aim of this work was to develop advanced and accessible protocols for noninvasive p... more Abstract: The aim of this work was to develop advanced and accessible protocols for noninvasive prenatal diagnosis of genetic diseases. We are evaluating different technologies for mutation detection, based on fluorescent probe hybridization of the amplified product and ...
ABSTRACT Postpartum hemorrhage (PPH) is defined as a blood loss >500 ml after vaginal ... more ABSTRACT Postpartum hemorrhage (PPH) is defined as a blood loss >500 ml after vaginal delivery or >1000 ml after cesarean delivery [1]. PPH occurs in fewer than 5% of all deliveries and is one of the major causes of maternal mortality worldwide, accounting for 15% of all maternal deaths and for a case–fatality rate of 1% [2]. Early PPH occurs within 24 h of delivery, while late PPH occurs from 24 h to 6 weeks post-partum. Primary causes of PPH include uter-ine atony (70% of cases), followed by retained placental/membrane fragments, lower genital tract lacerations, uterine rupture and hereditary coagulopathies [1,2]. Uterine artery pseudoaneurysm rupture is a rare cause of PPH after uterine surgical procedures, such as cesarean section or dilation and curettage in the great majority of cases [3,4]. This event is almost exceptional following a vaginal delivery [3]. We report a case of delayed intraperitoneal PPH after vaginal delivery secondary to subclini-cal uterine rupture and uterine artery pseudoa-neurysm, describing the diagnostic process, the management and treatment. We also reviewed the available literature on similar clinical expe-riences to draw final considerations on the management of such a rare event. Case report A 34-year-old woman, gravida 1 para 1, on day 5 postpartum, presented with diffuse abdominal pain irradiated to the lower quadrants, dysuria and urinary frequency persisting for several days. The patient had been discharged after an uncomplicated vaginal delivery of a single healthy fetus 5 days earlier in good general condition. The use of a single fundal pressure (Kristeller's maneuver) during the second stage of labor was recorded and postpartum recov-ery had been reported as normal in her hospital record. No use of oxytocic agents was reported. Aside from the symptoms referred, she was healthy and took no medication. Personal history was negative and no other significant element was reported; in particular, no gynecological surgical procedures emerged. Vital signs on admission – body tempera-ture, cardiac frequency, arterial pressure and
The Special Observation Period (SOP1), part of the HyMeX campaign (Hydrological cycle in the Medi... more The Special Observation Period (SOP1), part of the HyMeX campaign (Hydrological cycle in the Mediterranean Experiments, 5 September-6 November 2012), was dedicated to heavy precipitation events and flash floods in the western Mediterranean, and three Italian hydrometeorological monitoring sites were identified: Liguria-Tuscany, northeastern Italy and central Italy. The extraordinary deployment of advanced instrumentation, including instrumented aircrafts, and the use of several different operational weather forecast models, including hydrological models and marine models, allowed an unprecedented monitoring and analysis of high-impact weather events around the Italian hydro-meteorological sites. This activity has seen strong collaboration between the Italian scientific and operational communities. In this paper an overview of the Italian organization during SOP1 is provided, and selected Intensive Observation Periods (IOPs) are described. A significant event for each Italian target area is chosen for this analysis: IOP2 (12-13 September 2012) in northeastern Italy, IOP13 (15-16 October 2012) in central Italy and IOP19 (3-5 November 2012) in Liguria and Tuscany. For each IOP the meteorological characteristics, together with special observations and weather forecasts, are analyzed with the aim of highlighting strengths and weaknesses of the forecast modeling systems, including the hydrological impacts. The usefulness of having different weather forecast operational chains characterized by different numerical weather prediction models and/or different model set up or initial conditions is finally shown for one of the events (IOP19).
Abstract: The aim of this work was to develop advanced and accessible protocols for noninvasive p... more Abstract: The aim of this work was to develop advanced and accessible protocols for noninvasive prenatal diagnosis of genetic diseases. We are evaluating different technologies for mutation detection, based on fluorescent probe hybridization of the amplified product and ...
ABSTRACT Postpartum hemorrhage (PPH) is defined as a blood loss >500 ml after vaginal ... more ABSTRACT Postpartum hemorrhage (PPH) is defined as a blood loss >500 ml after vaginal delivery or >1000 ml after cesarean delivery [1]. PPH occurs in fewer than 5% of all deliveries and is one of the major causes of maternal mortality worldwide, accounting for 15% of all maternal deaths and for a case–fatality rate of 1% [2]. Early PPH occurs within 24 h of delivery, while late PPH occurs from 24 h to 6 weeks post-partum. Primary causes of PPH include uter-ine atony (70% of cases), followed by retained placental/membrane fragments, lower genital tract lacerations, uterine rupture and hereditary coagulopathies [1,2]. Uterine artery pseudoaneurysm rupture is a rare cause of PPH after uterine surgical procedures, such as cesarean section or dilation and curettage in the great majority of cases [3,4]. This event is almost exceptional following a vaginal delivery [3]. We report a case of delayed intraperitoneal PPH after vaginal delivery secondary to subclini-cal uterine rupture and uterine artery pseudoa-neurysm, describing the diagnostic process, the management and treatment. We also reviewed the available literature on similar clinical expe-riences to draw final considerations on the management of such a rare event. Case report A 34-year-old woman, gravida 1 para 1, on day 5 postpartum, presented with diffuse abdominal pain irradiated to the lower quadrants, dysuria and urinary frequency persisting for several days. The patient had been discharged after an uncomplicated vaginal delivery of a single healthy fetus 5 days earlier in good general condition. The use of a single fundal pressure (Kristeller's maneuver) during the second stage of labor was recorded and postpartum recov-ery had been reported as normal in her hospital record. No use of oxytocic agents was reported. Aside from the symptoms referred, she was healthy and took no medication. Personal history was negative and no other significant element was reported; in particular, no gynecological surgical procedures emerged. Vital signs on admission – body tempera-ture, cardiac frequency, arterial pressure and
The Special Observation Period (SOP1), part of the HyMeX campaign (Hydrological cycle in the Medi... more The Special Observation Period (SOP1), part of the HyMeX campaign (Hydrological cycle in the Mediterranean Experiments, 5 September-6 November 2012), was dedicated to heavy precipitation events and flash floods in the western Mediterranean, and three Italian hydrometeorological monitoring sites were identified: Liguria-Tuscany, northeastern Italy and central Italy. The extraordinary deployment of advanced instrumentation, including instrumented aircrafts, and the use of several different operational weather forecast models, including hydrological models and marine models, allowed an unprecedented monitoring and analysis of high-impact weather events around the Italian hydro-meteorological sites. This activity has seen strong collaboration between the Italian scientific and operational communities. In this paper an overview of the Italian organization during SOP1 is provided, and selected Intensive Observation Periods (IOPs) are described. A significant event for each Italian target area is chosen for this analysis: IOP2 (12-13 September 2012) in northeastern Italy, IOP13 (15-16 October 2012) in central Italy and IOP19 (3-5 November 2012) in Liguria and Tuscany. For each IOP the meteorological characteristics, together with special observations and weather forecasts, are analyzed with the aim of highlighting strengths and weaknesses of the forecast modeling systems, including the hydrological impacts. The usefulness of having different weather forecast operational chains characterized by different numerical weather prediction models and/or different model set up or initial conditions is finally shown for one of the events (IOP19).
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Papers by F. Pasi