Papers by Giorgio fano illic
European Journal of Translational Myology
Covid-19 disease is well documented and often the most common symptoms include myalgia and muscle... more Covid-19 disease is well documented and often the most common symptoms include myalgia and muscle fatigue. Approximately 10% of those infected complain of persistent fatigue even many months after the end of the acute phase of the disease. This gives rise to a condition different from the previous one and commonly known as 'post-acute COVID-19 syndrome' or simply Long-COVID. Although the origin of muscle fatigue is multifactorial, the state of prolonged fatigue observed in the Long-COVID syndrome suggests the existence of a possible state of atrophy or rather acute sarcopenia. Under these conditions, the use of physical activity programs can effectively counteract the state of atrophy underlying the fatigue phenomena observed. If this is also the situation during the Long-COVID, the muscular symptom should be positively influenced by the administration of programmed physical activity cycles. In fact, in patients with Long-COVID, the few published papers seem to indicate that...
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European Journal of Translational Myology, 2020
The man, more and more sedentary, lost step by step his physical capacities, aerobic, muscular st... more The man, more and more sedentary, lost step by step his physical capacities, aerobic, muscular strength, coordination, action-reaction time. This situation can be a reason, not only of absence from work (back pain is the first reason in EU), but especially of accident at work. In this EJTM Comunication we want to combine our experience about exercise physiology and physical capacities with our medical work in critical environment. We want to avoid the mistake to think that critical environment is only a high mountain or a desert. Thus, we consider very important to better define the concept of critical environment.
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Frontiers in psychology, 2016
The present study investigated the use of a tablet computer to assess figure-tracing skills and t... more The present study investigated the use of a tablet computer to assess figure-tracing skills and their relationships with psychological (visual-perceptual processes, cognitive processes, handwriting skills) and physiological (body mass index, isometric strength of arms) parameters with school-children of second (7-8-year-olds) and fourth (9-10-year-olds) grades. We were also interested in gender differences. The task required tracing of geometric figures on a template, shown on a tablet screen in light gray, for the segments that make up the target figure, one at a time. This figure-tracing tablet test allows acquisition and automated analysis of four parameters: number of strokes (pen lift) for each segment; oscillations of lines drawn with respect to reference lines; pressure of pen on tablet; and average speed of tracing. The results show a trade-off between speed and quality for the tablet parameters, with higher speed associated with more oscillations with respect to the referen...
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European Journal of Translational Myology, 2015
The first author, Elisa Gabrielli, has been a distance runner for many years, and then at a parti... more The first author, Elisa Gabrielli, has been a distance runner for many years, and then at a particular point in her career, she decided to move over to the 3000-m steeplechase. She was attracted by this discipline as she believed that it would be the appropriate discipline for her, due to the challenge it provided her, and the necessary knowledge and awareness she had through her studies. For reasons that are discussed in this report, the 3000-m steeplechase is a race that is more difficult to interpret and manage biomechanically and physiologically than most others. Combining this with her PhD allowed her to use a multidisciplinary approach to review the competitive experience gained in this discipline. During this period, she indeed not only deepened the technical aspects of her training, but also those that underlie this discipline, through her knowledge of sport, with particular reference to the female athlete. Through her technical research, she was able to take ‘snapshots’ of ...
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Frontiers in Psychology, 2015
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BioMed Research International, 2015
We propose a human-derived neuro-/glial cell three-dimensionalin vitromodel to investigate the ef... more We propose a human-derived neuro-/glial cell three-dimensionalin vitromodel to investigate the effects of microgravity on cell-cell interactions. A rotary cell-culture system (RCCS) bioreactor was used to generate a modelled microgravity environment, and morphofunctional features of glial-like GL15 and neuronal-like SH-SY5Y cells in three-dimensional individual cultures (monotypic aggregates) and cocultures (heterotypic aggregates) were analysed. Cell survival was maintained within all cell aggregates over 2 weeks of culture. Moreover, compared to cells as traditional static monolayers, cell aggregates cultured under modelled microgravity showed increased expression of specific differentiation markers (e.g., GL15 cells: GFAP, S100B; SH-SY5Y cells: GAP43) and modulation of functional cell-cell interactions (e.g., N-CAM and Cx43 expression and localisation). In conclusion, this culture model opens a wide range of specific investigations at the molecular, biochemical, and morphological...
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Journal of Applied Physiology, 2011
The study investigated the effect of prolonged hypoxia on central [i.e., cardiovascular oxygen de... more The study investigated the effect of prolonged hypoxia on central [i.e., cardiovascular oxygen delivery (Q̇aO2)] and peripheral (i.e., O2 utilization) determinants of oxidative metabolism response during exercise in humans. To this aim, seven male mountaineers were examined before and immediately after the Himalayan Expedition Interamnia 8000–Manaslu 2008, lasting 43 days, among which, 23 days were above 5,000 m. The subjects showed a decrease in body weight ( P < 0.05) and of power output during a Wingate Anaerobic test ( P < 0.05) and an increase of thigh cross-sectional area ( P < 0.05). Absolute maximal O2 uptake (V̇O2max) did not change. The mean response time of V̇O2 kinetics at the onset of step submaximal cycling exercise was reduced significantly from 53.8 s ± 10.9 to 39.8 s ± 10.9 ( P < 0.05), whereas that of Q̇aO2 was not. Analysis of single fibers dissected from vastus lateralis biopsies revealed that the expression of slow isoforms of both heavy and light my...
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European Journal of Translational Myology, 2020
The functional state of RyR depends on the intracellular calcium concentration and on the oxidati... more The functional state of RyR depends on the intracellular calcium concentration and on the oxidation state of its protein components in some particular sites and of some sentinel amino acids. In addition to the regulation of the RyR channel by exogenous substances (caffeine, ryanodine), ions environmental situations (oxidative state), other components, such as some endogenous proteins present in the sarcoplasm and/or and muscle membranes are able to determine changes in the Ca2+ channel activity. Among these, calmodulin and S-100A could determine the modification of channel status in the skeletal muscle. The currently available data can be justified if one uses a simplified S-100/CaM and RyR interaction model for the regulation of Ca2+ release in skeletal muscle. Under resting conditions, the CaM/S100A1 binding domain on RyR1 is predominantly dependent on S100A1. Vice versa when the intracellular Ca2+ concentration becomes high as well as during repetitive (tetanus) stimulation, the ...
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European Journal of Translational Myology, Mar 4, 2020
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Free radical biology & medicine, Jan 15, 2010
The biological effects of electric and magnetic fields, which are ubiquitous in modern society, r... more The biological effects of electric and magnetic fields, which are ubiquitous in modern society, remain poorly understood. Here, we applied a single-cell approach to study the effects of short-term exposure to extremely low frequency electromagnetic fields (ELF-EMFs) on muscle cell differentiation and function using C2C12 cells as an in vitro model of the skeletal muscle phenotype. Our focus was on markers of oxidative stress and calcium (Ca(2+)) handling, two interrelated cellular processes previously shown to be affected by such radiation in other cell models. Collectively, our data reveal that ELF-EMFs (1) induced reactive oxygen species production in myoblasts and myotubes with a concomitant decrease in mitochondrial membrane potential; (2) activated the cellular detoxification system, increasing catalase and glutathione peroxidase activities; and (3) altered intracellular Ca(2+)homeostasis, increasing the spontaneous activity of myotubes and enhancing cellular reactivity to a de...
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Journal of Applied Physiology, 2011
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Frontiers in Psychology, 2015
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European Journal of Translational Myology, 2013
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Papers by Giorgio fano illic