We are grateful for an opportunity to comment on the Cavanagh et al. response to our article. We ... more We are grateful for an opportunity to comment on the Cavanagh et al. response to our article. We hope that their note will encourage close reading of our article and we believe that some of the apparent differences between us dissolve with a better appreciation of our ...
For many years the agricultural sector has been seen as the best example of a closed quasi-corpor... more For many years the agricultural sector has been seen as the best example of a closed quasi-corporatist arrangement in British policy-making. The relationship between the Ministry of Agriculture, Fisheries and Food (h4AFF) and the Na-tional Farmers' Union (NFU) has ...
This paper confirms the existence of public interest groups as a theoretical puzzle for an Olson ... more This paper confirms the existence of public interest groups as a theoretical puzzle for an Olson type (economically-driven) rational choice explanation. It systematically reviews different theoretical approaches that challenge this appearance of paradox. The paper also introduces some British survey data. It concludes that rational choice analysis must subsume non-material incentives, but shows that discussions predicated on conceptions of rationality other than that used by Olson do not imply that participation is a problem to be explained. It also points to the importance of group activity in shaping the preferences of potential members and in stimulating membership.
This paper examines the place of groups in the consultative process in British policymaking. It s... more This paper examines the place of groups in the consultative process in British policymaking. It stresses the importance of consultation even under the Thatcher government and distinguishes between consultation, bargaining and negotiation. The paper identifies the important ...
Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic, childhood ons... more Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic, childhood onset, autoimmune diseases with variable clinical outcomes. We investigated whether profiling of the synovial fluid (SF) proteome by a fluorescent dye based, two-dimensional gel (DIGE) approach could distinguish patients in whom inflammation extends to affect a large number of joints, early in the disease process. SF samples from 22 JIA patients were analyzed: 10 with oligoarticular arthritis, 5 extended oligoarticular and 7 polyarticular disease. SF samples were labeled with Cy dyes and separated by two-dimensional electrophoresis. Multivariate analyses were used to isolate a panel of proteins which distinguish patient subgroups. Proteins were identified using MALDI-TOF mass spectrometry with expression further verified by Western immunoblotting and immunohistochemistry. Hierarchical clustering based on the expression levels of a set of 40 proteins segregated the extended oligoarticular from the oligoarticular patients (p < 0.05). Expression patterns of the isolated protein panel have also been observed over time, as disease spreads to multiple joints. The data indicates that synovial fluid proteome profiles could be used to stratify patients based on risk of disease extension. These protein profiles may also assist in monitoring therapeutic responses over time and help predict joint damage.
We hypothesise that following a bone fracture there is systemic recruitment of bone forming cells... more We hypothesise that following a bone fracture there is systemic recruitment of bone forming cells to a fracture site. A rabbit ulnar osteotomy model was adapted to trace the movement of osteogenic cells. Bone marrow mesenchymal stem cells from 41 NZW rabbits were isolated, culture-expanded and fluorescently labelled. The labelled cells were either re-implanted into the fracture gap (Group A); into a vein (Group B); or into a remote tibial bone marrow cavity 48 h after the osteotomy (Group C) or 4 weeks before the osteotomy was established (Group D), and a control group (Group E) had no labelled cells given. To quantify passive leakage of cells to an injury site, inert beads were also co-delivered in Group B. Samples of the fracture callus tissue and various organs were harvested at discrete sacrifice time-points to trace and quantify the labelled cells. At 3 weeks following osteotomy, the number of labelled cells identified in the callus of Group C, was significantly greater than following IV delivery, Group B, and there was no difference in the number of labelled cells in the callus tissues, between Groups C and A, indicating the labelled bone marrow cells were capable of migrating to the fracture sites from the remote bone marrow cavity. Significantly fewer inert beads than labelled cells were identified in Group B callus, suggesting some of the bone-forming cells were actively recruited and selectively chosen to the fracture site, rather than passively leaked into the circulation and to bone injury site. This investigation supports the hypothesis that some osteoblasts involved in fracture healing were systemically mobilised and recruited to the fracture from remote bone marrow sites.
Journal of Elections, Public Opinion & Parties, 2006
Abstract This article contributes to the discussion of one component of the crisis in political... more Abstract This article contributes to the discussion of one component of the crisis in political participation by looking at (non‐) participation in groups. The starting point is that political science has a heavy gauge tool for accounting for such low inactivityOlson&amp;amp;amp;amp;#x27;s (1965) free ...
... by their members in Brussels, they have nevertheless assumed an important role in the ... Eur... more ... by their members in Brussels, they have nevertheless assumed an important role in the ... Euro-watchers that the Commission would come to depend on well-organized groups operating ... Thus there is a familiar information deficit which often exists between agencies and interests. ...
This introduction seeks to sketch out the relationship between a variety of terms that are used i... more This introduction seeks to sketch out the relationship between a variety of terms that are used in contemporary discussion of the interaction between GovernmentlState and interest groups. It starts with a short reflection on the main theories of interest intermediationpluralism and corporatismand argues for reserving the term policy network as a generic label embracing different types of network relationship. This piece thus attempts to record the variety of labels currently used to describe statelinterest relations, to show the overlap between certain of these labels, and how they relate one to the other. The existing confusion of labels signal a greater variety than they deliver.
This article examines those public interest groups that have grown through heavy advertising expe... more This article examines those public interest groups that have grown through heavy advertising expenditure and sophisticated marketing techniques, most particularly direct mail solicitations. It suggests that an Olson-style rational choice understanding of this &amp;#x27;mail ...
Page 1. Issues in Environmental Politics The protest - Mobilizing campaign groups ■ -. Grant Jo... more Page 1. Issues in Environmental Politics The protest - Mobilizing campaign groups ■ -. Grant Jordan and William Maloney Page 2. Page 3. The protest business? Page 4. Issues in Environmental Politics series editors Tim O ...
ABSTRACT The article begins by comparing the use of terms such as policy community and sub govern... more ABSTRACT The article begins by comparing the use of terms such as policy community and sub government by different authors and in different (JS. and UK) political science traditions. Although accepting the major body of work that points to the erosion of sub governments, the authors argue that too much emphasis on the complexity and volatility of policy making masks underlying tendencies to stability and bargaining The need for the resolution of conflict both leads to perennial attempts to reconstruct islands of stability and to attempts to &quot;solve&quot; unique disputes by adopting some of the features that have been traditionally associated with sub governments. The authors identify the key characteristics of stable arrangements and attempt to explain their evolution by identifying the benefits of these arrangements for policy makers.
We are grateful for an opportunity to comment on the Cavanagh et al. response to our article. We ... more We are grateful for an opportunity to comment on the Cavanagh et al. response to our article. We hope that their note will encourage close reading of our article and we believe that some of the apparent differences between us dissolve with a better appreciation of our ...
For many years the agricultural sector has been seen as the best example of a closed quasi-corpor... more For many years the agricultural sector has been seen as the best example of a closed quasi-corporatist arrangement in British policy-making. The relationship between the Ministry of Agriculture, Fisheries and Food (h4AFF) and the Na-tional Farmers&amp;amp;#x27; Union (NFU) has ...
This paper confirms the existence of public interest groups as a theoretical puzzle for an Olson ... more This paper confirms the existence of public interest groups as a theoretical puzzle for an Olson type (economically-driven) rational choice explanation. It systematically reviews different theoretical approaches that challenge this appearance of paradox. The paper also introduces some British survey data. It concludes that rational choice analysis must subsume non-material incentives, but shows that discussions predicated on conceptions of rationality other than that used by Olson do not imply that participation is a problem to be explained. It also points to the importance of group activity in shaping the preferences of potential members and in stimulating membership.
This paper examines the place of groups in the consultative process in British policymaking. It s... more This paper examines the place of groups in the consultative process in British policymaking. It stresses the importance of consultation even under the Thatcher government and distinguishes between consultation, bargaining and negotiation. The paper identifies the important ...
Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic, childhood ons... more Juvenile idiopathic arthritis (JIA) comprises a poorly understood group of chronic, childhood onset, autoimmune diseases with variable clinical outcomes. We investigated whether profiling of the synovial fluid (SF) proteome by a fluorescent dye based, two-dimensional gel (DIGE) approach could distinguish patients in whom inflammation extends to affect a large number of joints, early in the disease process. SF samples from 22 JIA patients were analyzed: 10 with oligoarticular arthritis, 5 extended oligoarticular and 7 polyarticular disease. SF samples were labeled with Cy dyes and separated by two-dimensional electrophoresis. Multivariate analyses were used to isolate a panel of proteins which distinguish patient subgroups. Proteins were identified using MALDI-TOF mass spectrometry with expression further verified by Western immunoblotting and immunohistochemistry. Hierarchical clustering based on the expression levels of a set of 40 proteins segregated the extended oligoarticular from the oligoarticular patients (p < 0.05). Expression patterns of the isolated protein panel have also been observed over time, as disease spreads to multiple joints. The data indicates that synovial fluid proteome profiles could be used to stratify patients based on risk of disease extension. These protein profiles may also assist in monitoring therapeutic responses over time and help predict joint damage.
We hypothesise that following a bone fracture there is systemic recruitment of bone forming cells... more We hypothesise that following a bone fracture there is systemic recruitment of bone forming cells to a fracture site. A rabbit ulnar osteotomy model was adapted to trace the movement of osteogenic cells. Bone marrow mesenchymal stem cells from 41 NZW rabbits were isolated, culture-expanded and fluorescently labelled. The labelled cells were either re-implanted into the fracture gap (Group A); into a vein (Group B); or into a remote tibial bone marrow cavity 48 h after the osteotomy (Group C) or 4 weeks before the osteotomy was established (Group D), and a control group (Group E) had no labelled cells given. To quantify passive leakage of cells to an injury site, inert beads were also co-delivered in Group B. Samples of the fracture callus tissue and various organs were harvested at discrete sacrifice time-points to trace and quantify the labelled cells. At 3 weeks following osteotomy, the number of labelled cells identified in the callus of Group C, was significantly greater than following IV delivery, Group B, and there was no difference in the number of labelled cells in the callus tissues, between Groups C and A, indicating the labelled bone marrow cells were capable of migrating to the fracture sites from the remote bone marrow cavity. Significantly fewer inert beads than labelled cells were identified in Group B callus, suggesting some of the bone-forming cells were actively recruited and selectively chosen to the fracture site, rather than passively leaked into the circulation and to bone injury site. This investigation supports the hypothesis that some osteoblasts involved in fracture healing were systemically mobilised and recruited to the fracture from remote bone marrow sites.
Journal of Elections, Public Opinion & Parties, 2006
Abstract This article contributes to the discussion of one component of the crisis in political... more Abstract This article contributes to the discussion of one component of the crisis in political participation by looking at (non‐) participation in groups. The starting point is that political science has a heavy gauge tool for accounting for such low inactivityOlson&amp;amp;amp;amp;#x27;s (1965) free ...
... by their members in Brussels, they have nevertheless assumed an important role in the ... Eur... more ... by their members in Brussels, they have nevertheless assumed an important role in the ... Euro-watchers that the Commission would come to depend on well-organized groups operating ... Thus there is a familiar information deficit which often exists between agencies and interests. ...
This introduction seeks to sketch out the relationship between a variety of terms that are used i... more This introduction seeks to sketch out the relationship between a variety of terms that are used in contemporary discussion of the interaction between GovernmentlState and interest groups. It starts with a short reflection on the main theories of interest intermediationpluralism and corporatismand argues for reserving the term policy network as a generic label embracing different types of network relationship. This piece thus attempts to record the variety of labels currently used to describe statelinterest relations, to show the overlap between certain of these labels, and how they relate one to the other. The existing confusion of labels signal a greater variety than they deliver.
This article examines those public interest groups that have grown through heavy advertising expe... more This article examines those public interest groups that have grown through heavy advertising expenditure and sophisticated marketing techniques, most particularly direct mail solicitations. It suggests that an Olson-style rational choice understanding of this &amp;#x27;mail ...
Page 1. Issues in Environmental Politics The protest - Mobilizing campaign groups ■ -. Grant Jo... more Page 1. Issues in Environmental Politics The protest - Mobilizing campaign groups ■ -. Grant Jordan and William Maloney Page 2. Page 3. The protest business? Page 4. Issues in Environmental Politics series editors Tim O ...
ABSTRACT The article begins by comparing the use of terms such as policy community and sub govern... more ABSTRACT The article begins by comparing the use of terms such as policy community and sub government by different authors and in different (JS. and UK) political science traditions. Although accepting the major body of work that points to the erosion of sub governments, the authors argue that too much emphasis on the complexity and volatility of policy making masks underlying tendencies to stability and bargaining The need for the resolution of conflict both leads to perennial attempts to reconstruct islands of stability and to attempts to &quot;solve&quot; unique disputes by adopting some of the features that have been traditionally associated with sub governments. The authors identify the key characteristics of stable arrangements and attempt to explain their evolution by identifying the benefits of these arrangements for policy makers.
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