Papers by Jacqueline Marinac
The Journal of emergency medicine, 2004
We identified factors associated with radiograph evaluation for patients who presented to the Eme... more We identified factors associated with radiograph evaluation for patients who presented to the Emergency Department (ED) with uncomplicated low back pain (LBP). Using 1998-2000 ED data from the National Hospital Ambulatory Medical Care Survey, a multivariate analysis was performed to assess utilization of radiographs for LBP. Based upon published guidelines, of the over 3 million patients who met our criteria of uncomplicated LBP, 17.8% received an unnecessary radiograph. Patients who arrive via ambulance with moderate pain, who need to be seen within 15 min, and who have 3 or more screening tests ordered are 100% likely to also get a radiograph. There is an increased probability of receiving a radiograph for those patients 40-70 years old, being seen at a metropolitan hospital, having private insurance, and being treated by a resident in training. Multiple factors are associated with the overuse of radiographs for patients presenting with uncomplicated LBP.
Critical Care Medicine, Jul 1, 2000
Clinical Infectious Diseases, 1993
A severe hypersensitive reaction to trimethoprim-sulfamethoxazole in a patient infected with huma... more A severe hypersensitive reaction to trimethoprim-sulfamethoxazole in a patient infected with human immunodeficiency virus. JS Marinac, JF Stanford Clinical Infectious Diseases 16:11, 178-179, 1993. In response to the recent ...
Journal of Asthma, 1997
A retrospective, case-controlled analysis comparing patients admitted to a medical intensive care... more A retrospective, case-controlled analysis comparing patients admitted to a medical intensive care unit with severe exacerbations of asthma who received continuously nebulized albuterol (CNA) versus intermittent albuterol (INA) treatments is reported. Forty matched pairs of patients with asthma are compared. CNA was administered for a mean of 11 +/- 10 hr. The incidence of cardiac dysrhythmias was similar between groups. Symptomatic hypokalemia did not occur. CNA patients had higher heart rates during treatment, which may reflect severity of illness. The incidence of intubation was similar. We conclude that CNA and INA demonstrated similar profiles with regard to safety, morbidity, and mortality.
PubMed, Feb 1, 2005
Background and objectives: Evidence supports the routine use of low-dose aspirin (ASA) in the pre... more Background and objectives: Evidence supports the routine use of low-dose aspirin (ASA) in the prevention of cardiovascular (CV) events in patients with diabetes mellitus (DM). In 1997, the American Diabetes Association (ADA) recommended ASA prophylaxis for all diabetic patients over the age of 30 with one additional risk factor for cardiovascular disease (CVD). Our objective was to determine the adherence to the ADA guidelines for ASA therapy in DM using a national database. Methods: Data from the 1997-2000 National Ambulatory Medical Care Survey (NAMCS) was used to determine the usage rates of ASA in patients with DM over age 30 years with one or more CV risk factors. Multiple logistic regression methods were used to determine what factors were related to ASA prophylaxis. Results: During 1997-2000, more than one third of all diabetic patients should have been considered for ASA prophylaxis because they had one or more CV risk factors. Yet, from 1997-2000, the percentage of these patients given ASA for primary prevention was 2.8% in 1997, 2.9% in 1998, 2.1% in 1999, and 5.7% in 2000. Factors associated with increased ASA prophylaxis were non-white ethnicity, male gender, older age (more than 44 years old), rural clinic setting, preventative counseling given during visit, being prescribed more than two medications, having cardiovascular risk factors, and being seen by a cardiologist. Conclusions: Adherence rates to the ADA standard of care guideline regarding routine ASA prophylaxis in adults with DM and at least one CV risk factor are extremely low. National efforts directed at increasing these rates of ASA prophylaxis are indicated to meet the Healthy People 2010 goal of 30%.
Biopharmaceutics & Drug Disposition, Oct 1, 1995
Selegiline is beneficial to Parkinsonian patients as an adjunct to levodopa therapy. A sensitive ... more Selegiline is beneficial to Parkinsonian patients as an adjunct to levodopa therapy. A sensitive fluorimetric assay based on ibhibition of rat brain monoamine oxidase‐B (MAO‐B) in vitro has been developed to study the pharmacokinetics of selegiline. This method quantitates selegiline as low as 0.25 ng ml−1. The pharmacokinetics and relative bioavailability of selegiline were investigated in healthy volunteers following oral administration of 10 mg tablet or solution. A half‐life of approximately 70 min was observed following the administration of either dosage form. Although the two dosage forms exhibited a lag time, the absorption was rapid and peak plasma concentrations were observed between 30 and 45 min for the solution and 30 and 90 min for the tablets. Statistically no significant difference was found between Cmax, Tmax, AUC0‐∞ and MRT between the two dosage forms. Negligible renal clearance was found in both groups, but aparent oral plasma clearance was comparatively high and indicates rapid elimination of selegiline from the body.
Therapeutic Drug Monitoring, Apr 1, 1995
Obstetrics & Gynecology, Apr 1, 2003
Southern Medical Journal, Nov 1, 2003
American Journal of Therapeutics, 2001
The purpose of this investigation was to evaluate the effects of dopamine on heart rate (HR), sys... more The purpose of this investigation was to evaluate the effects of dopamine on heart rate (HR), systolic blood pressure (SBP), aldosterone, plasma renin activity (PRA), bradykinin, prolactin, corticotropin (ACTH), urinary output (UO), and urinary sodium (UNa) stratified by race. Sixteen healthy age- and weight-matched Caucasian and African American male subjects participated in this single-blind, three-phase study. The three phases included the following treatments and assessments: (i) 90-minute infusion of D(5)W 100 mL/h and control piggyback (control period); (ii) 90-minute infusion D(5)W 100 mL/h and 3 microg/kg/min dopamine (dopamine phase); (iii) assessments repeated 24 hours after dopamine administration (washout period). Plasma was analyzed for dopamine concentrations. Dopamine significantly increased HR and SBP across the study population. In addition, UO and UNa increased, prolactin was reversibly depressed, bradykinin and ACTH were unchanged, and aldosterone significantly rebounded on washout. With regard to race differences, SBP significantly increased in African Americans compared with Caucasians, and UNa significantly increased in Caucasians compared with African Americans. In summary, 3 microg/kg/min dopamine produced significant renal, hormonal, and hemodynamic changes in healthy men. Selected effects varied by race.
Journal of the American College of Cardiology, Mar 1, 2002
year changes in the ratio were beneficially affected by lifestyle factors, but only to a modest d... more year changes in the ratio were beneficially affected by lifestyle factors, but only to a modest degree. It is concerning that obesity at baseline contributes to a significant worsening of the ratio whereas a report of exercise only slightly improves the ratio.
Clinical Pharmacology & Therapeutics, Aug 1, 1996
Our objective was to study omeprazole as a single-dose oral probe in the determination of CYP2C19... more Our objective was to study omeprazole as a single-dose oral probe in the determination of CYP2C19 phenotype in black subjects and to determine the correlation between phenotype and genotype. This single-dose, open-label outpatient study was conducted at a community-based, university-affiliated teaching hospital outpatient clinic. Study subjects were 100 healthy, unrelated black adults (age range, 18 to 50 years) who were receiving no medications. Baseline omeprazole and 2-hour postingestion omeprazole and 5'-hydroxyomeprazole concentrations were measured for phenotype determination. Identification of CYP2C19m1 genotypes were performed with use of the polymerase chain reaction. Results were obtained for 28 men and 72 women. Ninety-eight subjects were found to be phenotypically extensive metabolizers and two to be poor metabolizers (one man; one smoker). Genotype determination revealed that the two poor metabolizers of omeprazole were homozygous for a single base pair mutation (m1/m1) in exon 5 of CYP2C19. Twenty-eight of the extensive metabolizers were heterozygous (m1/wt) and the remaining 70 were homozygous (wt/wt). No side effects were reported. The 2% prevalence rate of poor CYP2C19 metabolizers in this healthy black population residing in the Midwestern United States is similar to that reported in white subjects and in the Shona population of Zimbabwe but much less than in Asian subjects. Omeprazole is a safe and specific probe of the CYP2C19 enzyme system that correlates well with genotype.
OBJECTIVE: The primaryobjectiveof this articleis to providereaders with case reportsof drug- or c... more OBJECTIVE: The primaryobjectiveof this articleis to providereaders with case reportsof drug- or chemical-induced asepticmeningitis (DCAM) describedin the medical literature. Background information regarding the classificationof DCAM, incidence, proposedmechanisms, associated risk factors, clinicalmanagement, and sequelaeis presented. DATA SOURCES: A MEDLINEsearchwas used to identifypertinent background literature and case reportsof OCAM. DATA EXTRACTIO:-l: All case reportsof OCAM involveanecdotal information. A criticalanalysis of a causal relationshipto the implicated drug or chemicaland the appearanceof meningeal involvement is presented. Animaldata are included when pertinent. DATA SYNTIfF-SIS: OCAM is a rare adverseevent associated with numerous agents.Patientspresent with a varietyof clinicalsignsand symptomsand laboratory findings of cerebralspinal fluid, when
Objective. To describe and evaluate drug errors and related clinical pharma-cist interventions. D... more Objective. To describe and evaluate drug errors and related clinical pharma-cist interventions. Design.Cross-sectional observational study with an online data collection form. Setting.American College of Clinical Pharmacy practice-based research net-work (ACCP PBRN). Participants.A total of 62 clinical pharmacists from the ACCP PBRN who provided direct patient care in the inpatient and outpatient practice settings. Intervention.Clinical pharmacist participants identified drug errors in their usual practices and submitted online error reports over a period of 14 consecutive days during 2010. Measurements and Main Results. The 62 clinical pharmacists submitted 924 reports; of these, 779 reports from 53 clinical pharmacists had complete data. Drug errors occurred in both the inpatient (61%) and outpatient
Biopharmaceutics & Drug Disposition, 1995
... IFTEKHAR MAHMOOD*:, JACQUELINE S. MARINAC', SANDRA WILLSIE' AND WIL... more ... IFTEKHAR MAHMOOD*:, JACQUELINE S. MARINAC', SANDRA WILLSIE' AND WILLIAM D. MASON* *Department of Pharmaceutics, School of Pharmacy ... on pharmacokinetics of selegiline, Magyer and Tothfalusi* administered labeled deprenyl (14C) to rats via IVY IP, and SC ...
Biopharmaceutics & Drug Disposition
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Papers by Jacqueline Marinac