SMO'05 Proceedings of the 5th WSEAS international conference on Simulation, modelling and optimization, Aug 17, 2005
This paper is based on interactive work between disciplines of engineering and pharmacy. Authors ... more This paper is based on interactive work between disciplines of engineering and pharmacy. Authors used well known reliability techniques [1] to study the probabilistic effect of pain relieving medicines such as naproxen on animals subjected to pain causing chemical such as acetic acid. Nanoparticles are the first and foremost representative frontiers of colloidal drug delivery systems and have a solid polymer matrix. Nanoparticles are often defined as particulate dispersions having a size range between 30nm and 500 nm. Due to their extreme small size, nanoparticles may be administered through the normal routes of administration and can be used to target a particular organ. This is contrary to regular drugs administered orally which go through gastro-intestinal tract, liver and finally to the heart. From the heart the drug is distributed to all the organs of the body including the particular organ that is being targeted. This approach was used to study the analgesic effect of naproxen loaded nanoparticles. Three types of such nanoparticles containing different matrix materials (1) ethyl cellulose (2) cholesterol and (3) a combination of ethylcellulose and cholesterol are prepared. Naproxen, one of the most commonly used analgesic drugs, is loaded into the above mentioned formulations. The analgesic effect of naproxen was tested by comparing the activity of suspension of a commercial product of naproxen with that of naproxen loaded nanoparticles. The analgesic activity of naproxen-loaded nanoparticles (Dose-2.5mg/kg-bodyweight) following intra-peritoneal administration was assessed by measuring the reduction in number of writhings produced in the albino mice in 15min. upon injecting 0.3ml of 1%-acetic acid intra-peritoneally. To assess the rate and extent of analgesia, the writhings were measured at 1, 12 and 24-hours after the treatment with the control and test preparations. For each of the group, the statistical average of number of writhings is calculated along with standard deviation. The idea is to study the effect of pain relieving effect of naproxen dose (commercial and non commercial) on the animal induced with pain-causing acetic acid. In the end, probability of the animal having normal writhings is calculated. This work is based on the Ph.D. thesis of the first author, Kuchibhotla [2].
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