La distrofia muscular de Duchenne (Duchenne, 1868) (DMD: MIM 310200) es la enfermedad hereditaria... more La distrofia muscular de Duchenne (Duchenne, 1868) (DMD: MIM 310200) es la enfermedad hereditaria ligada al cromosoma X má s frecuente en el hombre, ya que afecta a uno de cada 3.500 varones nacidos 1 .
Connexins are thought to solely mediate cell-to-cell communication by forming gap junction channe... more Connexins are thought to solely mediate cell-to-cell communication by forming gap junction channels composed of two membrane-spanning hemichannels positioned end-to-end. However, many if not all connexin isoforms also form functional hemichannels (i.e., the precursors of complete channels) that mediate the rapid exchange of ions, second messengers and metabolites between the cell interior and the interstitial space. Electrical and molecular signaling via connexin hemichannels is now widely recognized to be important in many physiological scenarios and pathological conditions. Indeed, mutations in connexins that alter hemichannel function have been implicated in several diseases. Here, we present a comprehensive overview of how hemichannel activity is tightly regulated by membrane potential and the external calcium concentration. In addition, we discuss the genetic mutations known to alter hemichannel function and their deleterious effects, of which a better understanding is necessary to develop novel therapeutic approaches for diseases caused by hemichannel dysfunction.
A fraction has been isolated from baker's yeast that is able to inactivate fructose 1,6-bisphosph... more A fraction has been isolated from baker's yeast that is able to inactivate fructose 1,6-bisphosphatase in vitro. The inactivating fraction is heat labile, non-dialysable and is precipitated with ammonium sulfate ; thus indicating that it is a protein. Malate dehydrogenase, hexokinase, glucose phosphate isomerase, glucose-6-phosphate dehydrogenase, glutamate dehydrogenase and catalase from baker's yeast and fructose 1,6-bisphosphatase from the yeast Rhodotorula glutinis were not inactivated by the preparation.
La distrofia muscular de Duchenne (Duchenne, 1868) (DMD: MIM 310200) es la enfermedad hereditaria... more La distrofia muscular de Duchenne (Duchenne, 1868) (DMD: MIM 310200) es la enfermedad hereditaria ligada al cromosoma X má s frecuente en el hombre, ya que afecta a uno de cada 3.500 varones nacidos 1 .
Connexins are thought to solely mediate cell-to-cell communication by forming gap junction channe... more Connexins are thought to solely mediate cell-to-cell communication by forming gap junction channels composed of two membrane-spanning hemichannels positioned end-to-end. However, many if not all connexin isoforms also form functional hemichannels (i.e., the precursors of complete channels) that mediate the rapid exchange of ions, second messengers and metabolites between the cell interior and the interstitial space. Electrical and molecular signaling via connexin hemichannels is now widely recognized to be important in many physiological scenarios and pathological conditions. Indeed, mutations in connexins that alter hemichannel function have been implicated in several diseases. Here, we present a comprehensive overview of how hemichannel activity is tightly regulated by membrane potential and the external calcium concentration. In addition, we discuss the genetic mutations known to alter hemichannel function and their deleterious effects, of which a better understanding is necessary to develop novel therapeutic approaches for diseases caused by hemichannel dysfunction.
A fraction has been isolated from baker's yeast that is able to inactivate fructose 1,6-bisphosph... more A fraction has been isolated from baker's yeast that is able to inactivate fructose 1,6-bisphosphatase in vitro. The inactivating fraction is heat labile, non-dialysable and is precipitated with ammonium sulfate ; thus indicating that it is a protein. Malate dehydrogenase, hexokinase, glucose phosphate isomerase, glucose-6-phosphate dehydrogenase, glutamate dehydrogenase and catalase from baker's yeast and fructose 1,6-bisphosphatase from the yeast Rhodotorula glutinis were not inactivated by the preparation.
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Papers by Jesus Molano