Revista Española de Cardiología (English Edition), 2012
A 59-year-old woman with Marfan syndrome underwent surgery in 1999 to treat an acute aortic disse... more A 59-year-old woman with Marfan syndrome underwent surgery in 1999 to treat an acute aortic dissection. The ascending aorta was replaced with a 30 mm diameter Dacron tube. The postoperative clinical course was uneventful and the patient was discharged at 15 days following surgery.
Interactive cardiovascular and thoracic surgery, 2014
Left ventricular free wall rupture and acute ischaemic mitral regurgitation are nowadays rare, bu... more Left ventricular free wall rupture and acute ischaemic mitral regurgitation are nowadays rare, but still potentially lethal mechanical complications after acute myocardial infarction. We report a case of a sequential left ventricular free wall rupture, anterolateral papillary muscle disruption, secondary severe mitral regurgitation and subsequent posteromedial papillary muscle head rupture in a single patient during the same ischaemic episode after myocardial infarction, and their related successful surgical procedures and management until discharge. Prompt bedside diagnosis and emergent consecutive surgical procedures, as well as temporary left ventricular assistance, were crucial in the survival of this patient.
Background: The atrium is the major site of ANP synthesis, which has been said to increase in hea... more Background: The atrium is the major site of ANP synthesis, which has been said to increase in heart failure as a result of increased production in the left ventricular (LV) myocardium. This is a key issue related to its diagnostic and prognostic capabilities. We aimed to evaluate protein levels of proANP and ANP and the enzymes that cleave the natriuretic peptides, corin and furin, in the LV tissue of heart transplant patients with dilated (DCM) and ischemic (ICM) cardiomyopathy compared with control donors (CNT). We also evaluate mRNA levels of ANP gene (NPPA) by RNA sequencing in the same tissue.
A carpet with presence detector consists of a big capacitor manufactured with usual materials ins... more A carpet with presence detector consists of a big capacitor manufactured with usual materials inside the textile fabrication process, instead of metal sheet and dielectric plastics, ceramics, etc. It is a challenge to build a robust capacitor for an environment subject to frequent deformations. Moreover, we must add the difficulty of detecting small changes in the capacity of considerably big
Changes in cardiomyocyte cytoskeletal components, a crucial scaffold of cellular structure, have ... more Changes in cardiomyocyte cytoskeletal components, a crucial scaffold of cellular structure, have been found in heart failure (HF); however, the altered cytoskeletal network remains to be elucidated. This study investigated a new map of cytoskeleton-linked alterations that further explain the cardiomyocyte morphology and contraction disruption in HF. RNA-Sequencing (RNA-Seq) analysis was performed in 29 human LV tissue samples from ischemic cardiomyopathy (ICM; n=13) and dilated cardiomyopathy (DCM, n=10) patients undergoing cardiac transplantation and six healthy donors (control, CNT) and up to 16 ICM, 13 DCM and 7 CNT tissue samples for qRT-PCR. Gene Ontology analysis of RNA-Seq data demonstrated that cytoskeletal processes are altered in HF. We identified 60 differentially expressed cytoskeleton-related genes in ICM and 58 genes in DCM comparing with CNT, hierarchical clustering determined that shared cytoskeletal genes have a similar behavior in both pathologies. We further investigated MYLK4, RHOU, and ANKRD1 cytoskeletal components. qRT-PCR analysis revealed that MYLK4 was downregulated (-2.2-fold; P<0.05) and ANKRD1 was upregulated (2.3-fold; P<0.01) in ICM patients vs CNT. RHOU mRNA levels showed a statistical trend to decrease (-2.9-fold). In DCM vs CNT, MYLK4 (-4.0-fold; P<0.05) and RHOU (-3.9-fold;…
Revista Española de Cardiología (English Edition), 2012
A 59-year-old woman with Marfan syndrome underwent surgery in 1999 to treat an acute aortic disse... more A 59-year-old woman with Marfan syndrome underwent surgery in 1999 to treat an acute aortic dissection. The ascending aorta was replaced with a 30 mm diameter Dacron tube. The postoperative clinical course was uneventful and the patient was discharged at 15 days following surgery.
Interactive cardiovascular and thoracic surgery, 2014
Left ventricular free wall rupture and acute ischaemic mitral regurgitation are nowadays rare, bu... more Left ventricular free wall rupture and acute ischaemic mitral regurgitation are nowadays rare, but still potentially lethal mechanical complications after acute myocardial infarction. We report a case of a sequential left ventricular free wall rupture, anterolateral papillary muscle disruption, secondary severe mitral regurgitation and subsequent posteromedial papillary muscle head rupture in a single patient during the same ischaemic episode after myocardial infarction, and their related successful surgical procedures and management until discharge. Prompt bedside diagnosis and emergent consecutive surgical procedures, as well as temporary left ventricular assistance, were crucial in the survival of this patient.
Background: The atrium is the major site of ANP synthesis, which has been said to increase in hea... more Background: The atrium is the major site of ANP synthesis, which has been said to increase in heart failure as a result of increased production in the left ventricular (LV) myocardium. This is a key issue related to its diagnostic and prognostic capabilities. We aimed to evaluate protein levels of proANP and ANP and the enzymes that cleave the natriuretic peptides, corin and furin, in the LV tissue of heart transplant patients with dilated (DCM) and ischemic (ICM) cardiomyopathy compared with control donors (CNT). We also evaluate mRNA levels of ANP gene (NPPA) by RNA sequencing in the same tissue.
A carpet with presence detector consists of a big capacitor manufactured with usual materials ins... more A carpet with presence detector consists of a big capacitor manufactured with usual materials inside the textile fabrication process, instead of metal sheet and dielectric plastics, ceramics, etc. It is a challenge to build a robust capacitor for an environment subject to frequent deformations. Moreover, we must add the difficulty of detecting small changes in the capacity of considerably big
Changes in cardiomyocyte cytoskeletal components, a crucial scaffold of cellular structure, have ... more Changes in cardiomyocyte cytoskeletal components, a crucial scaffold of cellular structure, have been found in heart failure (HF); however, the altered cytoskeletal network remains to be elucidated. This study investigated a new map of cytoskeleton-linked alterations that further explain the cardiomyocyte morphology and contraction disruption in HF. RNA-Sequencing (RNA-Seq) analysis was performed in 29 human LV tissue samples from ischemic cardiomyopathy (ICM; n=13) and dilated cardiomyopathy (DCM, n=10) patients undergoing cardiac transplantation and six healthy donors (control, CNT) and up to 16 ICM, 13 DCM and 7 CNT tissue samples for qRT-PCR. Gene Ontology analysis of RNA-Seq data demonstrated that cytoskeletal processes are altered in HF. We identified 60 differentially expressed cytoskeleton-related genes in ICM and 58 genes in DCM comparing with CNT, hierarchical clustering determined that shared cytoskeletal genes have a similar behavior in both pathologies. We further investigated MYLK4, RHOU, and ANKRD1 cytoskeletal components. qRT-PCR analysis revealed that MYLK4 was downregulated (-2.2-fold; P<0.05) and ANKRD1 was upregulated (2.3-fold; P<0.01) in ICM patients vs CNT. RHOU mRNA levels showed a statistical trend to decrease (-2.9-fold). In DCM vs CNT, MYLK4 (-4.0-fold; P<0.05) and RHOU (-3.9-fold;…
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Papers by José Montero