Lorne Mendell

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David Seamon

Kansas State University

Luis Cadahia

University of Oslo

Brent Thoma

Jackson State University

Raoul Bongers

University of Groningen

Jan N . Bremmer

University of Groningen

Prasath Jayakaran

University of Otago

Andrew W Kandel

Heidelberg Academy of Sciences and Humanities

Viacheslav Kuleshov

Stockholm University

Volker Knappertz

Heinrich Heine University Düsseldorf

ÖMER ERTUĞRUL

Ahi Evran University

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Papers by Lorne Mendell

The Segmental motor system

Oxford University Press eBooks, 1990

Douglas G. Stuart: Henneman's contributions in historical perspective Section I: Properties a... more Douglas G. Stuart: Henneman's contributions in historical perspective Section I: Properties and functional organization of segmental motor systems: Gerald E. Loeb: The functional organization of muscles, motor units, and tasks Daniel Kernell: Spinal motoneurons and their muscle fibers: mechanisms and long-term consequences of common activation patterns V. C. Abrahams, P. K. Rose, & F. J. R. Richmond: Properties and control of the neck musculature Section II: The orderly recruitment of motor units: Blair Calancie, & Parveen Bawa: Motor unit recruitment in man Felix E. Zajac: Coupling of recruitment order to the force produced by motor units: The "size principle hypothesis" revisited Albert J. Berger: Orderly recruitment of phrenic motoneurons Section III: Properties of motoneurons: Wilfrid Rall: Perspectives on neuron modeling V. R. Edgerton, R. R. Roy, & G. R. Chalmers: Does the size principle give insight into the energy requirements of motoneurons? Martin J. Pinter: The role of motoneuron membrane properties in the determination of recruitment order C. J. Heckman, Marc D. Binder: Neural mechanisms underlying the orderly recruitment of motoneurons Section IV: Properties of motor units and muscle fibers: R. E. Burke: Motor unit types: some history and unsettled issues Stephen J. Goldberg: Mechanical properties of extraocular motor units H. Peter Clamann: Changes that occur in motor units during activity Patti M. Nemeth: Metabolic fiber types and influences on their transformations Richard B. Stein, Tessa Gordon, & Joanne Totosy de Zepetnek: Mechanisms for respecifying muscle properties following reinnervation Section V: Synaptic inputs to motoneurons: John B. Munson: Synaptic inputs to type-identified motor units Lorne M. Mendell, William F. Collins, III, & H. Richard Koerber: How are Ia synapses distributed on spinal motoneurons to permit orderly recruitment? Hans R. Luscher: Transmission failure and its relief in the spinal monosynaptic reflex arc P. Rudomin: Presynaptic control of synaptic effectiveness of muscle spindle and tendon organ afferents in the mammalian spinal cord E. E. Fetz, & P. D. Cheney: Functional properties of primate corticomotoneuronal cells: Comparisons with spindle afferents and motor units.

Neurotrophins and Pain

Elsevier eBooks, 2008

Classical work with neurotrophins, especially with nerve growth factor (NGF) that was the initial... more Classical work with neurotrophins, especially with nerve growth factor (NGF) that was the initially discovered neurotrophin, indicated their crucial role as survival factors for sensory neurons during development as embodied in the neurotrophic hypothesis. This, coupled with evidence that they enhanced the growth of neural processes, provided a linchpin for our understanding of neural development, especially of sensory and motor neurons. It has now become apparent that neurotrophins act throughout the life span of the organism and that after birth they take on a different role. NGF is required in the periphery for postnatal differentiation of certain classes of nociceptors. Additionally, NGF acts to increase the sensitivity of nociceptors via an acute action in sensitizing the response to certain stimuli and chronically via upregulation of a number of receptors important in nociceptor function. A different neurotrophin, brain-derived neurotrophic factor (BDNF), upregulated in the soma of tropomyosin-related kinase A-positive (trkA+) sensory neurons during inflammation and released into the spinal cord, acts centrally to sensitize the response of neurons in the superficial dorsal horn to glutamate released by peripheral nociceptors. Recent data indicate that neurotrophins sensitize nociceptive responses in virtually all peripheral tissues. Thus, neurotrophins are widely distributed in different tissues and sensitize many nociceptor functions in their functional action, suggesting that they are poised to contribute to hyperalgesic states. Recent evidence stresses the importance of gaining further understanding of these molecules in order to achieve better insight into how to treat clinical pain states.

Neurotrophins and sensory neurons: role in development, maintenance and injury. A thematic summary

Philosophical Transactions of the Royal Society B, Mar 29, 1996

Cells in sensory ganglia have constituted a very productive model system to examine the biology o... more Cells in sensory ganglia have constituted a very productive model system to examine the biology of the neurotrophins. Reasons for this have included the accessibility of the cells and their processes to studies of development, function and plasticity after injury. Despite their apparent homogeneity at the gross level sensory neurons are highly differentiated in their anatomy, physiology, chemistry, etc. Their response to neurotrophins varies among the different cell types which has helped to elucidate the action of these agents. It is the purpose of this brief review to summarize a number of overriding themes that emerge from these studies as discussed at the meeting on Neurotrophins and sensory neurons: role in development, maintenance and injury . Reference is made throughout to contributions of the speakers at this meeting whose papers may be consulted for further detail and for the appropriate references.

Neurotrophin action on sensory neurons in adults: an extension of the neurotrophic hypothesis

Pain, Aug 1, 1999

This brief review explores the action of neurotrophins on sensory neurons in adults. Neutralizati... more This brief review explores the action of neurotrophins on sensory neurons in adults. Neutralization of neurotrophins in adults does not cause sensory neurons to die as it does in prenatal animals. Thus they are not required as survival factors in adults. However, neurotrophins continue to play important roles in the postnatal development of sensory neurons. They also exert strong effects on the anatomy and physiology of these fibers after axotomy in adults. Here we review of the effects of NT-3 on spindle afferent fibers and NGF on nociceptive afferents and consider possible extension of the neurotrophic hypothesis to adults.

Lorne Mendell

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