The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associ... more The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), vitronectin (Vn), Plasminogen activator inhibitor-1 (PAI-1) activity and tissue plasminogen activator (t-PA) levels in early-onset preeclampsia, late-onset preeclampsia and in control pregnant women. A total of 79 individuals, 30 early-onsets, and 22 late-onset preeclamptic and 27 control pregnant women were included into the scope of this study. Enzyme-linked immunosorbent assay procedure was used to determine the serum Lp-PLA2 and plasma Vn, t-PA antigen and PAI-1 activity levels. Serum C-reactive protein (CRP) levels were measured immunoturbidimetrically in routine clinical chemistry analyser. In patients with preeclampsia, Lp-PLA2, PAI-1, t-PA, CRP and blood pressures levels were increased (p = 0.000) and correlated with each other. Vn levels were decreased (p = 0.016) but not correlated with other parameters in preeclamptic patients. We are of the opinion that increased Lp-PLA2 levels may partially contribute to endothelial dysfunction by the progression of inflammation. In addition, increased complex formation with Vn is likely to bring about the increase of PAI-1 activity in patients with preeclampsia. Moreover, increased t-PA and decreased Vn levels may also be the consequences of compensatory mechanisms against disease progression.
92 (63.4%) vs. 57 (45.6%) were obese. During 3-years follow-up 34 diabetic pts (23.4%) suffered f... more 92 (63.4%) vs. 57 (45.6%) were obese. During 3-years follow-up 34 diabetic pts (23.4%) suffered from myocardial infarction (MI), 3 of them were fatal, compare to 13 cases (10.4%) without T2D (p=0.0059) (Table).16 diabetic and 18 non-diabetic pts underwent heart revascularization. The incidence rate of MACE increased in T2D pts from 5.3% with non-obstructive to 93.3% with multi-vessels obstructive CAD; in pts without diabetes from 0% to 71.4% (p=0.0001), from 25.9% to 100% with increasing CACS score from 400 to 1000 in diabetic and from 5.2% to 75% in non-diabetic pts (p=0.0001). CCTA and CACS for myocardial infarction No. of events/No. of total patients (event rate %) Type 2 diabetes Without diabetes n=145 n=125 No CAD 0/2 (0)-Non-obs CAD 2/38 (5.3) 0/42 (0) 1-vessels obs CAD 5/41 (9.7) 1/50 (2) 2-vessels obs CAD 13/39 (33.3) 7/26 (26.9) 3-vessels obs CAD 14/15 (93.3) 5/7 (71.4) CACS=0 0/2 (0)-CACS 1-99 0/18 (0) 0/11 (0) CACS 100-399 6/40 (15.0) 0/25 (0) CACS 400-999 20/77 (25.9) 4/77 (5.2) CACS >1000 8/8 (100) 9/12 (75) CAD, coronary artery disease; obs, obstructive. Conclusion: CCTA and CACS may be considered a valuable tool for detection of CAD severity, intensive preventive treatment, and early revascularization to decrease an incidence of MACE.
Introduction: The purpose of this study was to investigate the time course(s) of the serum hyalur... more Introduction: The purpose of this study was to investigate the time course(s) of the serum hyaluronidase levels in patients with aneurysmal subarachnoid haemorrhage and to show whether there is a correlation between symptomatic vasospasm and serum levels of hyaluronidase. Methods: This prospective, open, non-randomised clinical study consisted of 20 patients with aneurysmal subarachnoid haemorrhage, and eight patients with normotensive hydrocephalus who served as the control group. Serum hyaluronidase levels were detected within the first three days, days five and seven after aneurysmal subarachnoid haemorrhage, and the results were compared with those from the control group. The results were also compared with those of the clinical parameters, including the patient's outcome at six months and symptomatic vasospasm. Results: Mean serum hyaluronidase levels were higher on days five and seven, and comparisons with either day five (p-value is 0.001) and/or day seven (p-value is 0.00001) showed a statistical difference between subarachnoid haemorrhage and controls. However, no relationship was found between elevated serum hyaluronidase levels and the clinical parameters including symptomatic vasospasm (p-value is greater than 0.05) and outcome at sixth months (p-value is greater than 0.05). Conclusion: Our results indicate that serum hyaluronidase is elevated in the acute stage(s) of subarachnoid haemorrhage; however, no difference was found between serum hyaluronidase levels and subarachnoid haemorrhage severity. Clinical studies with larger population of patients with aneurysmal subarachnoid haemorrhage are required.
Vitamin D kemik ve mineral metabolizmas› ile yak›ndan ilgilidir. Gebe kad›nlardaki vitamin D eksi... more Vitamin D kemik ve mineral metabolizmas› ile yak›ndan ilgilidir. Gebe kad›nlardaki vitamin D eksikli-¤i do¤ufltan riketse neden olmaktad›r (1,2). Annenin D vitamini eksikli¤i emzirme döneminde de devam etti¤i takdirde anne sütü ile beslenen bebeklerde rikets riski artmaktad›r (3-5). Rikets; epifizler kapanmadan önce, geliflmekte olan kemik dokusunun mineralizasyon bo-zuklu¤u ile belirgin bir hastal›kt›r. En s›k nedeni D vitamini yetersizli¤idir. Halk sa¤l›¤› aç›s›ndan bak›ld›¤›nda D vitamini yetersizli¤i önemli bir sorundur ve bu ne-denle fetal yaflamdan itibaren yeterli D vitamini kayna-¤› sa¤lanmal›d›r (4-5). Erken bebeklik döneminde D vitamini kaynaklar› plasental geçifl, anne sütü ve günefl ›fl›¤› yoluyla derideki sentezdir (1,6,7). Yaflam›n ilk sekiz haftas›nda bebeklerin serum 25(OH) D vitamini düzeyleri annelerinki ile iliflkiliydi, sonraki aylarda ise günefl ›fl›¤› daha belirleyici bir etmen olmaktad›r (8). Annenin ve anne sütü D vitamini düzeyleri aras›ndaki iliflki göz önüne al›nd›¤›nda, erken bebeklik döneminde belirgin ve az belirgin D vitamini yetersizli¤i aç›s›ndan en önemli risk etmeninin annedeki D vitamini eksikli¤i oldu¤u aç›kt›r. Son y›llarda annenin D vitamin düzey-Y Ya az z› ›fl flm ma a A Ad dr re es si i: :
Background: The aim of our study was to find out whether exercise of the pelvic muscles during va... more Background: The aim of our study was to find out whether exercise of the pelvic muscles during vaginal delivery increases maternal and cord blood irisin levels. Methods: This prospective study included 20 patients who vaginally delivered their babies and 20 patients that underwent elective cesarean section. In the vaginal delivery group, delivery occured either spontaneously or by induction. In the other group, the patients were electively operated before uterine contractions started. We compared serum irisin levels of the two groups and cord blood irisin levels of the babies of these mothers. Results: There was no statistically significant difference in maternal serum irisin levels between the two groups (p > 0.05). We also found no statistically significant difference in cord blood irisin levels (p > 0.05). The positive correlation between maternal and cord blood irisin levels was found to be statistically significant (p < 0.05). We also detected a significant positive correlation between maternal irisin levels and BMI in our study (p < 0.05). Conclusions: Irisin is a challenging molecule. Although we did not find a significant difference in the irisin levels of women according to the method of delivery, we feel that further investigations are warranted.
Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2007
Aim: Our aim was to evaluate maternal vitamin D levels of pregnant women in the third trimester M... more Aim: Our aim was to evaluate maternal vitamin D levels of pregnant women in the third trimester Material and Method: 44 pregnant women in the third trimester applying to Taksim Hospital Gynecology and Obstetrics Department from 1st February to 30th April 2005 were included in this study Serum 25 OH vitamin D calcium Ca phosphorus P and alkalene phosphatase ALP levels were measured by radioimmunoassay RIA and otomation system respectively Results: The mean age of pregnant women was 25 4±3 5 years Serum Ca levels were 8 87±0 42 mg dL P levels 3 58±0 64 mg dL ALP levels 395±92 U L and 25 OH nbsp; vitamin D levels were measured as 11 1±3 80 ng mL nbsp; Depending on the reference level of the laboratory 25 OH vitamin D levels were found below 10 ng mL which is the lower limit for winter in 31 70 45 cases and 10 25 ng mL in 13 cases 29 54 Conclusions: Mothers who applied to our Gynecology and Obstetrics Department have a poor vitamin D status This is a significant risk factor with regard ...
International Journal of Medical Biochemistry, 2020
Serum level of vitamin D in obstructive sleep apnea patients with fibromyalgia syndrome O bstruct... more Serum level of vitamin D in obstructive sleep apnea patients with fibromyalgia syndrome O bstructive sleep apnea syndrome (OSAS) is a disease defined by recurrent episodes of upper airway obstruction and sporadic oxygen desaturation during sleep. Patients with OSAS suffer from a low quality of life as a consequence of persistent deficient quality sleep. The prevalence of OSAS has been reported at 1% to 5% in various studies and is more common in males than females [1]. Fibromyalgia syndrome (FMS) is a relatively new, yet now commonly seen disorder characterized by various symptoms, such as tender points, musculoskeletal pain, sleep disturbance, memory problems, and fatigue lasting for at least 3 months. FMS is seen more frequently in women than men; however, the exact etiology and pathogenesis of FMS remains unclear [2]. Vitamins are essential nutrients required in very small amounts for normal development and health. Vitamins are classified as fat soluble or water soluble. Among the fat-soluble vitamins, vitamin D has a crucial role [3]. Although the main function of vitamin D is to provide adequate amounts of calcium and phosphate for a healthy mineralized skeleton, it is now also considered an important immunomodulatory hormone be-Objectives: The aim of this study was to investigate the serum concentration of vitamin D in patients with obstructive sleep apnea syndrome (OSAS) alone and with coexisting fibromyalgia syndrome (FMS) and to assess the relationship to pain. Methods: A total of 60 patients diagnosed with OSAS and 40 healthy individuals whose age and sex were analogous to the patient group were included in this study. The OSAS patients were examined for FMS according to the American College of Rheumatology criteria, and 27 cases were identified. Group 1 consisted of patients with OSAS alone (n=33) and Group 2 comprised patients with FMS+OSAS (n=27). Serum samples were analyzed using an ultra-performance liquid chromatography analyzer (Thermo Dionex Ultimate 3000; Thermo Fisher Scientific, Inc., Waltham, MA, USA). Results: A comparison of the OSAS and FMS+OSAS groups with the healthy individuals revealed that the vitamin D level was significantly lower in the patient groups (Group 1: p=0.001, Group 2: p=0.038). No statistically significant difference was found in the vitamin D level between the subgroups of OSAS and FMS+OSAS. A weak negative correlation was determined between the number of the tender points (r=-0.428) and the vitamin D level in the subjects with FMS (p=0.013). In addition, the oxygen desaturation values of the FMS+OSAS and OSAS patient groups were significantly different (p=0.001). Conclusion: Patients with OSAS and FMS+OSAS had a low vitamin D level, which should be considered when planning treatment strategies.
Objectives: The aim of this study was to evaluate tubular functions of posterior urethral valve p... more Objectives: The aim of this study was to evaluate tubular functions of posterior urethral valve patients with preserved glomerular functions. Methods: A total of 25 children (ages 1-18) who underwent surgery for PUV and had an estimated glomerular filtration rate ≥ 90 mL/min per 1.73 m 2 on long term follow-up and age-matched 25 healthy controls were enrolled. Blood and urine samples were collected to assess electrolyte reabsorption, proteinuria, enzymuria, urine acidification and concentration. Results: Even though microalbumin/creatinine ratio was higher in the patient group [1.00 (1.98) vs 0.31 (0.34) mg/gr creatinine, P = 0.005] none of the subjects had enzymuria, overt proteinuria or hyperphosphaturia. Serum bicarbonate levels were lower and urinary pH higher in patients than the controls (23.2 ± 2.1 vs. 24.6 ± 1.9 mmol/L, P = 0.028 and 6.24 ± 0.77 vs. 5.60 ± 0.64, P = 0.004); furthermore, patients had lower urinary osmolality and density (525 ± 214 vs. 743 ± 194 mOsm/L, P = 0.001 and 1011 ± 5.0 vs. 1016 ± 6.8, P = 0.005). When patients were compared among themselves according to presence or absence of renal scarring and when patients without renal scars were compared to healthy controls, similar findings persisted. Conclusions: This study showed that during long-term follow-up of posterior urethral valve patients with normal glomerular filtration rates, even though proximal tubular functions do not seem to be impaired, acidification and concentration defects exist indicating distal tubulopathy.
Background: Abnormal eating behavior, unhealthy weight control methods, and eating disordered sym... more Background: Abnormal eating behavior, unhealthy weight control methods, and eating disordered symptoms have risen among college students. Objectives: The aim of this study was to examine disordered eating attitudes and their relationship with anthropometric and body composition indices in physical education students in Tabriz, the capital of East Azerbaijan province, Iran. Patients and Methods: This cross-sectional study was conducted on 210 physical education students, 105 males and 105 females aged 18 to 25, who were selected by systematic random sampling from physical education faculty of Tabriz University in Tabriz, Iran, in 2013. Eating attitude test (EAT-26) was used for the assessment of disordered eating attitudes. In addition, anthropometric and body composition indices were assessed. Results: About 10% of the studied subject had disturbed eating attitudes; significantly more males (15.4%) reported an EAT-26 ≥ 20 (disordered eating attitudes) than females (4.8%) (P < 0.05). In males, the EAT-26 score was positively correlated with weist perimeter (WP) (r = 0.21, P < 0.05) and the waist-to-hip ratio (r = 0.26, P < 0.01). In females, the EAT-26 score was positively correlated with weight (r = 0.19, P < 0.05) and the WP (r = 0.28, P < 0.01). In females, weight (P < 0.05), body mass index (BMI) (P < 0.05), WP (P < 0.01), and waist-to-hip ratio (P < 0.05) were significantly different between disordered eating attitude and healthy subjects, while in males there was no significant difference between the two groups regarding the anthropometric and body composition indices. Conclusions: Abnormal eating attitude was notable among physical education students in Tabriz, Iran. It seems that some anthropometric indices such as BMI and central obesity indices were related to the increase of disordered eating attitude.
Introduction: Celiac disease is an autoimmune disorder that involves gluten intolerance and can b... more Introduction: Celiac disease is an autoimmune disorder that involves gluten intolerance and can be triggered by environmental factors including hepatitis B virus (HBV) infection. This study aimed to describe the prevalence of celiac disease in individuals with HBV infection and to describe the clinical and laboratory characteristics of celiac disease associated with HBV. Methods: This cross-sectional study included 50 hepatitis B patients tested for IgA anti-endomysial antibodies (EMAs) and tissue antitransglutaminase (TTG) between August 2011 and September 2012. Results: Fifty patients were included with a mean age of 46.0 ± 12.6 (46.0) years; 46% were female and 13% were HBeAg+. Six patients had positive serology for celiac disease, four were EMA+, and fi ve were TTG+. When individuals with positive serology for celiac disease were compared to those with negative serology, they demonstrated a higher prevalence of abdominal pain (100% vs. 33.3%, p = 0.008), lower median creatinine (0.7mg/dL vs. 0.9mg/dL, p = 0.007) and lower mean albumin (3.6 ± 0.4g/L vs. 3.9 ± 0.3g/L, p = 0.022). All individuals with positive serology for celiac disease underwent upper digestive endoscopy, and three of the patients exhibited a macroscopic pattern suggestive of celiac disease. Histologically, fi ve patients demonstrated an intra-epithelial lymphocytic infi ltrate level > 30%, and four patients showed villous atrophy associated with crypt hyperplasia on duodenal biopsy. Conclusions: An increased prevalence of celiac disease was observed among hepatitis B patients. These patients were symptomatic and had signifi cant laboratory abnormalities. These results indicate that active screening for celiac disease among HBV-infected adults is warranted.
measured. Results: Histopathologically, basal membranes were thickened and there was intense infl... more measured. Results: Histopathologically, basal membranes were thickened and there was intense inflammatory reaction in diabetic lungs. However, the PDTC group, in which there were poor positive expressions of eNOS and p65 activity compared to diabetes group, revealed fewer inflammatory changes. PCC levels in diabetic lungs were higher, but SOD and GSH activities were lower. However, measurements of these parameters in the PDTC group and controls gave similar results. Conclusion: Lungs are exposed to changes induced by oxidative stress in diabetes through NF-B activation and PDTC seems to be useful to prevent diabetic lung injury.
Journal of Maternal-fetal & Neonatal Medicine, May 30, 2019
Abstract Objective The study tested whether cardiovascular corresponding LPA risk genotypes impro... more Abstract Objective The study tested whether cardiovascular corresponding LPA risk genotypes improve pre-eclampsia and coronary heart disease (CHD) risk prediction beyond conventional risk factors. Background Studies have shown that women specific risk factors for cardiovascular disease (CVD) have taken an attention recently. It might be possible to identify women who have the highest risk in developing CVD in their further lives. It is well-known that Lp(a) levels have an impact on increased risk of CVD which is affected by LPA gene. Further, LPA risk genotypes are not considered in cardiovascular risk prediction. Methods We have included 200 pregnant Turkish women into the study. We stratified the preeclamptic (PE) group: early (EOP) (28.7 ± 3.0 weeks) and late onset (LOP) (36.0 ± 1.4 weeks). 14 LPA SNPs were evaluated in the study. Rs9355296 and rs3798220 were found as independent risk factors for preeclampsia by logistic regression analysis. A positive correlation was found between rs9355296 and the diagnostic criteria of preeclampsia. Further rs9355296 G/* carriers have higher vascular inflammation rather than AA carriers. Conclusions The findings reveal that LPA genetic variability with high inflammatory response might be an indication of future cardiovascular events.
Archives of Gynecology and Obstetrics, Dec 20, 2014
The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associ... more The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), vitronectin (Vn), Plasminogen activator inhibitor-1 (PAI-1) activity and tissue plasminogen activator (t-PA) levels in early-onset preeclampsia, late-onset preeclampsia and in control pregnant women. A total of 79 individuals, 30 early-onsets, and 22 late-onset preeclamptic and 27 control pregnant women were included into the scope of this study. Enzyme-linked immunosorbent assay procedure was used to determine the serum Lp-PLA2 and plasma Vn, t-PA antigen and PAI-1 activity levels. Serum C-reactive protein (CRP) levels were measured immunoturbidimetrically in routine clinical chemistry analyser. In patients with preeclampsia, Lp-PLA2, PAI-1, t-PA, CRP and blood pressures levels were increased (p = 0.000) and correlated with each other. Vn levels were decreased (p = 0.016) but not correlated with other parameters in preeclamptic patients. We are of the opinion that increased Lp-PLA2 levels may partially contribute to endothelial dysfunction by the progression of inflammation. In addition, increased complex formation with Vn is likely to bring about the increase of PAI-1 activity in patients with preeclampsia. Moreover, increased t-PA and decreased Vn levels may also be the consequences of compensatory mechanisms against disease progression.
Amaç Pol k st k over sendromlu (PKOS) kadınlardak nsül n d renc le serum copept n düzey arasındak... more Amaç Pol k st k over sendromlu (PKOS) kadınlardak nsül n d renc le serum copept n düzey arasındak olası l şk y ortaya koymaktır. Gereç ve Yöntemler Benzer yaş ve vücut k tle ndeks ne (VKİ) sah p 44 PKOS'lu ve 44 sağlıklı kadın çalışmaya dah l ed ld. Kadınların demograf k, kl n k ve laboratuvar b lg ler dosyalarından elde ed ld. Adet n 2-4. günler arası alınan örnekte serum copept n düzey ölçüldü. PKOS ve sağlıklı kadınların ver ler karşılaştırıldı. Serum copept n düzey n n anlamlı çıkan değ şkenlerle korelasyonu değerlend r ld. Bulgular PKOS'lu kadınlarda, kl n k açıdan nfert l te, h rşut zm, akne, c ltte yağlanma ve saç dökülmes daha fazla, Ferr man-Gallwey Skoru (FGS) daha yüksek, adetler arası süre daha uzundu (bütün değ şkenlerde p <0,05). PKOS'lu kadınlarda; LH, Serbest testesteron, toplam testesteron, DHEA-SO4, açlık nsül n, HOMA-IR ve copept n düzeyler le nsül n d renc oranı yüksek saptandı (bütün değ şkenlerde p <0,05). Serum copept n düzey azalan sırayla HOMA-IR, açlık nsül n, AMH, toplam testesteron, serbest testesteron ve LH düzey yle poz t f korele saptandı (sırasıyla p1:
The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associ... more The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), vitronectin (Vn), Plasminogen activator inhibitor-1 (PAI-1) activity and tissue plasminogen activator (t-PA) levels in early-onset preeclampsia, late-onset preeclampsia and in control pregnant women. A total of 79 individuals, 30 early-onsets, and 22 late-onset preeclamptic and 27 control pregnant women were included into the scope of this study. Enzyme-linked immunosorbent assay procedure was used to determine the serum Lp-PLA2 and plasma Vn, t-PA antigen and PAI-1 activity levels. Serum C-reactive protein (CRP) levels were measured immunoturbidimetrically in routine clinical chemistry analyser. In patients with preeclampsia, Lp-PLA2, PAI-1, t-PA, CRP and blood pressures levels were increased (p = 0.000) and correlated with each other. Vn levels were decreased (p = 0.016) but not correlated with other parameters in preeclamptic patients. We are of the opinion that increased Lp-PLA2 levels may partially contribute to endothelial dysfunction by the progression of inflammation. In addition, increased complex formation with Vn is likely to bring about the increase of PAI-1 activity in patients with preeclampsia. Moreover, increased t-PA and decreased Vn levels may also be the consequences of compensatory mechanisms against disease progression.
92 (63.4%) vs. 57 (45.6%) were obese. During 3-years follow-up 34 diabetic pts (23.4%) suffered f... more 92 (63.4%) vs. 57 (45.6%) were obese. During 3-years follow-up 34 diabetic pts (23.4%) suffered from myocardial infarction (MI), 3 of them were fatal, compare to 13 cases (10.4%) without T2D (p=0.0059) (Table).16 diabetic and 18 non-diabetic pts underwent heart revascularization. The incidence rate of MACE increased in T2D pts from 5.3% with non-obstructive to 93.3% with multi-vessels obstructive CAD; in pts without diabetes from 0% to 71.4% (p=0.0001), from 25.9% to 100% with increasing CACS score from 400 to 1000 in diabetic and from 5.2% to 75% in non-diabetic pts (p=0.0001). CCTA and CACS for myocardial infarction No. of events/No. of total patients (event rate %) Type 2 diabetes Without diabetes n=145 n=125 No CAD 0/2 (0)-Non-obs CAD 2/38 (5.3) 0/42 (0) 1-vessels obs CAD 5/41 (9.7) 1/50 (2) 2-vessels obs CAD 13/39 (33.3) 7/26 (26.9) 3-vessels obs CAD 14/15 (93.3) 5/7 (71.4) CACS=0 0/2 (0)-CACS 1-99 0/18 (0) 0/11 (0) CACS 100-399 6/40 (15.0) 0/25 (0) CACS 400-999 20/77 (25.9) 4/77 (5.2) CACS >1000 8/8 (100) 9/12 (75) CAD, coronary artery disease; obs, obstructive. Conclusion: CCTA and CACS may be considered a valuable tool for detection of CAD severity, intensive preventive treatment, and early revascularization to decrease an incidence of MACE.
Introduction: The purpose of this study was to investigate the time course(s) of the serum hyalur... more Introduction: The purpose of this study was to investigate the time course(s) of the serum hyaluronidase levels in patients with aneurysmal subarachnoid haemorrhage and to show whether there is a correlation between symptomatic vasospasm and serum levels of hyaluronidase. Methods: This prospective, open, non-randomised clinical study consisted of 20 patients with aneurysmal subarachnoid haemorrhage, and eight patients with normotensive hydrocephalus who served as the control group. Serum hyaluronidase levels were detected within the first three days, days five and seven after aneurysmal subarachnoid haemorrhage, and the results were compared with those from the control group. The results were also compared with those of the clinical parameters, including the patient's outcome at six months and symptomatic vasospasm. Results: Mean serum hyaluronidase levels were higher on days five and seven, and comparisons with either day five (p-value is 0.001) and/or day seven (p-value is 0.00001) showed a statistical difference between subarachnoid haemorrhage and controls. However, no relationship was found between elevated serum hyaluronidase levels and the clinical parameters including symptomatic vasospasm (p-value is greater than 0.05) and outcome at sixth months (p-value is greater than 0.05). Conclusion: Our results indicate that serum hyaluronidase is elevated in the acute stage(s) of subarachnoid haemorrhage; however, no difference was found between serum hyaluronidase levels and subarachnoid haemorrhage severity. Clinical studies with larger population of patients with aneurysmal subarachnoid haemorrhage are required.
Vitamin D kemik ve mineral metabolizmas› ile yak›ndan ilgilidir. Gebe kad›nlardaki vitamin D eksi... more Vitamin D kemik ve mineral metabolizmas› ile yak›ndan ilgilidir. Gebe kad›nlardaki vitamin D eksikli-¤i do¤ufltan riketse neden olmaktad›r (1,2). Annenin D vitamini eksikli¤i emzirme döneminde de devam etti¤i takdirde anne sütü ile beslenen bebeklerde rikets riski artmaktad›r (3-5). Rikets; epifizler kapanmadan önce, geliflmekte olan kemik dokusunun mineralizasyon bo-zuklu¤u ile belirgin bir hastal›kt›r. En s›k nedeni D vitamini yetersizli¤idir. Halk sa¤l›¤› aç›s›ndan bak›ld›¤›nda D vitamini yetersizli¤i önemli bir sorundur ve bu ne-denle fetal yaflamdan itibaren yeterli D vitamini kayna-¤› sa¤lanmal›d›r (4-5). Erken bebeklik döneminde D vitamini kaynaklar› plasental geçifl, anne sütü ve günefl ›fl›¤› yoluyla derideki sentezdir (1,6,7). Yaflam›n ilk sekiz haftas›nda bebeklerin serum 25(OH) D vitamini düzeyleri annelerinki ile iliflkiliydi, sonraki aylarda ise günefl ›fl›¤› daha belirleyici bir etmen olmaktad›r (8). Annenin ve anne sütü D vitamini düzeyleri aras›ndaki iliflki göz önüne al›nd›¤›nda, erken bebeklik döneminde belirgin ve az belirgin D vitamini yetersizli¤i aç›s›ndan en önemli risk etmeninin annedeki D vitamini eksikli¤i oldu¤u aç›kt›r. Son y›llarda annenin D vitamin düzey-Y Ya az z› ›fl flm ma a A Ad dr re es si i: :
Background: The aim of our study was to find out whether exercise of the pelvic muscles during va... more Background: The aim of our study was to find out whether exercise of the pelvic muscles during vaginal delivery increases maternal and cord blood irisin levels. Methods: This prospective study included 20 patients who vaginally delivered their babies and 20 patients that underwent elective cesarean section. In the vaginal delivery group, delivery occured either spontaneously or by induction. In the other group, the patients were electively operated before uterine contractions started. We compared serum irisin levels of the two groups and cord blood irisin levels of the babies of these mothers. Results: There was no statistically significant difference in maternal serum irisin levels between the two groups (p > 0.05). We also found no statistically significant difference in cord blood irisin levels (p > 0.05). The positive correlation between maternal and cord blood irisin levels was found to be statistically significant (p < 0.05). We also detected a significant positive correlation between maternal irisin levels and BMI in our study (p < 0.05). Conclusions: Irisin is a challenging molecule. Although we did not find a significant difference in the irisin levels of women according to the method of delivery, we feel that further investigations are warranted.
Turk Pediatri Arsivi-turkish Archives of Pediatrics, 2007
Aim: Our aim was to evaluate maternal vitamin D levels of pregnant women in the third trimester M... more Aim: Our aim was to evaluate maternal vitamin D levels of pregnant women in the third trimester Material and Method: 44 pregnant women in the third trimester applying to Taksim Hospital Gynecology and Obstetrics Department from 1st February to 30th April 2005 were included in this study Serum 25 OH vitamin D calcium Ca phosphorus P and alkalene phosphatase ALP levels were measured by radioimmunoassay RIA and otomation system respectively Results: The mean age of pregnant women was 25 4±3 5 years Serum Ca levels were 8 87±0 42 mg dL P levels 3 58±0 64 mg dL ALP levels 395±92 U L and 25 OH nbsp; vitamin D levels were measured as 11 1±3 80 ng mL nbsp; Depending on the reference level of the laboratory 25 OH vitamin D levels were found below 10 ng mL which is the lower limit for winter in 31 70 45 cases and 10 25 ng mL in 13 cases 29 54 Conclusions: Mothers who applied to our Gynecology and Obstetrics Department have a poor vitamin D status This is a significant risk factor with regard ...
International Journal of Medical Biochemistry, 2020
Serum level of vitamin D in obstructive sleep apnea patients with fibromyalgia syndrome O bstruct... more Serum level of vitamin D in obstructive sleep apnea patients with fibromyalgia syndrome O bstructive sleep apnea syndrome (OSAS) is a disease defined by recurrent episodes of upper airway obstruction and sporadic oxygen desaturation during sleep. Patients with OSAS suffer from a low quality of life as a consequence of persistent deficient quality sleep. The prevalence of OSAS has been reported at 1% to 5% in various studies and is more common in males than females [1]. Fibromyalgia syndrome (FMS) is a relatively new, yet now commonly seen disorder characterized by various symptoms, such as tender points, musculoskeletal pain, sleep disturbance, memory problems, and fatigue lasting for at least 3 months. FMS is seen more frequently in women than men; however, the exact etiology and pathogenesis of FMS remains unclear [2]. Vitamins are essential nutrients required in very small amounts for normal development and health. Vitamins are classified as fat soluble or water soluble. Among the fat-soluble vitamins, vitamin D has a crucial role [3]. Although the main function of vitamin D is to provide adequate amounts of calcium and phosphate for a healthy mineralized skeleton, it is now also considered an important immunomodulatory hormone be-Objectives: The aim of this study was to investigate the serum concentration of vitamin D in patients with obstructive sleep apnea syndrome (OSAS) alone and with coexisting fibromyalgia syndrome (FMS) and to assess the relationship to pain. Methods: A total of 60 patients diagnosed with OSAS and 40 healthy individuals whose age and sex were analogous to the patient group were included in this study. The OSAS patients were examined for FMS according to the American College of Rheumatology criteria, and 27 cases were identified. Group 1 consisted of patients with OSAS alone (n=33) and Group 2 comprised patients with FMS+OSAS (n=27). Serum samples were analyzed using an ultra-performance liquid chromatography analyzer (Thermo Dionex Ultimate 3000; Thermo Fisher Scientific, Inc., Waltham, MA, USA). Results: A comparison of the OSAS and FMS+OSAS groups with the healthy individuals revealed that the vitamin D level was significantly lower in the patient groups (Group 1: p=0.001, Group 2: p=0.038). No statistically significant difference was found in the vitamin D level between the subgroups of OSAS and FMS+OSAS. A weak negative correlation was determined between the number of the tender points (r=-0.428) and the vitamin D level in the subjects with FMS (p=0.013). In addition, the oxygen desaturation values of the FMS+OSAS and OSAS patient groups were significantly different (p=0.001). Conclusion: Patients with OSAS and FMS+OSAS had a low vitamin D level, which should be considered when planning treatment strategies.
Objectives: The aim of this study was to evaluate tubular functions of posterior urethral valve p... more Objectives: The aim of this study was to evaluate tubular functions of posterior urethral valve patients with preserved glomerular functions. Methods: A total of 25 children (ages 1-18) who underwent surgery for PUV and had an estimated glomerular filtration rate ≥ 90 mL/min per 1.73 m 2 on long term follow-up and age-matched 25 healthy controls were enrolled. Blood and urine samples were collected to assess electrolyte reabsorption, proteinuria, enzymuria, urine acidification and concentration. Results: Even though microalbumin/creatinine ratio was higher in the patient group [1.00 (1.98) vs 0.31 (0.34) mg/gr creatinine, P = 0.005] none of the subjects had enzymuria, overt proteinuria or hyperphosphaturia. Serum bicarbonate levels were lower and urinary pH higher in patients than the controls (23.2 ± 2.1 vs. 24.6 ± 1.9 mmol/L, P = 0.028 and 6.24 ± 0.77 vs. 5.60 ± 0.64, P = 0.004); furthermore, patients had lower urinary osmolality and density (525 ± 214 vs. 743 ± 194 mOsm/L, P = 0.001 and 1011 ± 5.0 vs. 1016 ± 6.8, P = 0.005). When patients were compared among themselves according to presence or absence of renal scarring and when patients without renal scars were compared to healthy controls, similar findings persisted. Conclusions: This study showed that during long-term follow-up of posterior urethral valve patients with normal glomerular filtration rates, even though proximal tubular functions do not seem to be impaired, acidification and concentration defects exist indicating distal tubulopathy.
Background: Abnormal eating behavior, unhealthy weight control methods, and eating disordered sym... more Background: Abnormal eating behavior, unhealthy weight control methods, and eating disordered symptoms have risen among college students. Objectives: The aim of this study was to examine disordered eating attitudes and their relationship with anthropometric and body composition indices in physical education students in Tabriz, the capital of East Azerbaijan province, Iran. Patients and Methods: This cross-sectional study was conducted on 210 physical education students, 105 males and 105 females aged 18 to 25, who were selected by systematic random sampling from physical education faculty of Tabriz University in Tabriz, Iran, in 2013. Eating attitude test (EAT-26) was used for the assessment of disordered eating attitudes. In addition, anthropometric and body composition indices were assessed. Results: About 10% of the studied subject had disturbed eating attitudes; significantly more males (15.4%) reported an EAT-26 ≥ 20 (disordered eating attitudes) than females (4.8%) (P < 0.05). In males, the EAT-26 score was positively correlated with weist perimeter (WP) (r = 0.21, P < 0.05) and the waist-to-hip ratio (r = 0.26, P < 0.01). In females, the EAT-26 score was positively correlated with weight (r = 0.19, P < 0.05) and the WP (r = 0.28, P < 0.01). In females, weight (P < 0.05), body mass index (BMI) (P < 0.05), WP (P < 0.01), and waist-to-hip ratio (P < 0.05) were significantly different between disordered eating attitude and healthy subjects, while in males there was no significant difference between the two groups regarding the anthropometric and body composition indices. Conclusions: Abnormal eating attitude was notable among physical education students in Tabriz, Iran. It seems that some anthropometric indices such as BMI and central obesity indices were related to the increase of disordered eating attitude.
Introduction: Celiac disease is an autoimmune disorder that involves gluten intolerance and can b... more Introduction: Celiac disease is an autoimmune disorder that involves gluten intolerance and can be triggered by environmental factors including hepatitis B virus (HBV) infection. This study aimed to describe the prevalence of celiac disease in individuals with HBV infection and to describe the clinical and laboratory characteristics of celiac disease associated with HBV. Methods: This cross-sectional study included 50 hepatitis B patients tested for IgA anti-endomysial antibodies (EMAs) and tissue antitransglutaminase (TTG) between August 2011 and September 2012. Results: Fifty patients were included with a mean age of 46.0 ± 12.6 (46.0) years; 46% were female and 13% were HBeAg+. Six patients had positive serology for celiac disease, four were EMA+, and fi ve were TTG+. When individuals with positive serology for celiac disease were compared to those with negative serology, they demonstrated a higher prevalence of abdominal pain (100% vs. 33.3%, p = 0.008), lower median creatinine (0.7mg/dL vs. 0.9mg/dL, p = 0.007) and lower mean albumin (3.6 ± 0.4g/L vs. 3.9 ± 0.3g/L, p = 0.022). All individuals with positive serology for celiac disease underwent upper digestive endoscopy, and three of the patients exhibited a macroscopic pattern suggestive of celiac disease. Histologically, fi ve patients demonstrated an intra-epithelial lymphocytic infi ltrate level > 30%, and four patients showed villous atrophy associated with crypt hyperplasia on duodenal biopsy. Conclusions: An increased prevalence of celiac disease was observed among hepatitis B patients. These patients were symptomatic and had signifi cant laboratory abnormalities. These results indicate that active screening for celiac disease among HBV-infected adults is warranted.
measured. Results: Histopathologically, basal membranes were thickened and there was intense infl... more measured. Results: Histopathologically, basal membranes were thickened and there was intense inflammatory reaction in diabetic lungs. However, the PDTC group, in which there were poor positive expressions of eNOS and p65 activity compared to diabetes group, revealed fewer inflammatory changes. PCC levels in diabetic lungs were higher, but SOD and GSH activities were lower. However, measurements of these parameters in the PDTC group and controls gave similar results. Conclusion: Lungs are exposed to changes induced by oxidative stress in diabetes through NF-B activation and PDTC seems to be useful to prevent diabetic lung injury.
Journal of Maternal-fetal & Neonatal Medicine, May 30, 2019
Abstract Objective The study tested whether cardiovascular corresponding LPA risk genotypes impro... more Abstract Objective The study tested whether cardiovascular corresponding LPA risk genotypes improve pre-eclampsia and coronary heart disease (CHD) risk prediction beyond conventional risk factors. Background Studies have shown that women specific risk factors for cardiovascular disease (CVD) have taken an attention recently. It might be possible to identify women who have the highest risk in developing CVD in their further lives. It is well-known that Lp(a) levels have an impact on increased risk of CVD which is affected by LPA gene. Further, LPA risk genotypes are not considered in cardiovascular risk prediction. Methods We have included 200 pregnant Turkish women into the study. We stratified the preeclamptic (PE) group: early (EOP) (28.7 ± 3.0 weeks) and late onset (LOP) (36.0 ± 1.4 weeks). 14 LPA SNPs were evaluated in the study. Rs9355296 and rs3798220 were found as independent risk factors for preeclampsia by logistic regression analysis. A positive correlation was found between rs9355296 and the diagnostic criteria of preeclampsia. Further rs9355296 G/* carriers have higher vascular inflammation rather than AA carriers. Conclusions The findings reveal that LPA genetic variability with high inflammatory response might be an indication of future cardiovascular events.
Archives of Gynecology and Obstetrics, Dec 20, 2014
The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associ... more The aim of the current study is to determine, correlate and compare the plasma lipoprotein-associated phospholipase A2 (Lp-PLA2), vitronectin (Vn), Plasminogen activator inhibitor-1 (PAI-1) activity and tissue plasminogen activator (t-PA) levels in early-onset preeclampsia, late-onset preeclampsia and in control pregnant women. A total of 79 individuals, 30 early-onsets, and 22 late-onset preeclamptic and 27 control pregnant women were included into the scope of this study. Enzyme-linked immunosorbent assay procedure was used to determine the serum Lp-PLA2 and plasma Vn, t-PA antigen and PAI-1 activity levels. Serum C-reactive protein (CRP) levels were measured immunoturbidimetrically in routine clinical chemistry analyser. In patients with preeclampsia, Lp-PLA2, PAI-1, t-PA, CRP and blood pressures levels were increased (p = 0.000) and correlated with each other. Vn levels were decreased (p = 0.016) but not correlated with other parameters in preeclamptic patients. We are of the opinion that increased Lp-PLA2 levels may partially contribute to endothelial dysfunction by the progression of inflammation. In addition, increased complex formation with Vn is likely to bring about the increase of PAI-1 activity in patients with preeclampsia. Moreover, increased t-PA and decreased Vn levels may also be the consequences of compensatory mechanisms against disease progression.
Amaç Pol k st k over sendromlu (PKOS) kadınlardak nsül n d renc le serum copept n düzey arasındak... more Amaç Pol k st k over sendromlu (PKOS) kadınlardak nsül n d renc le serum copept n düzey arasındak olası l şk y ortaya koymaktır. Gereç ve Yöntemler Benzer yaş ve vücut k tle ndeks ne (VKİ) sah p 44 PKOS'lu ve 44 sağlıklı kadın çalışmaya dah l ed ld. Kadınların demograf k, kl n k ve laboratuvar b lg ler dosyalarından elde ed ld. Adet n 2-4. günler arası alınan örnekte serum copept n düzey ölçüldü. PKOS ve sağlıklı kadınların ver ler karşılaştırıldı. Serum copept n düzey n n anlamlı çıkan değ şkenlerle korelasyonu değerlend r ld. Bulgular PKOS'lu kadınlarda, kl n k açıdan nfert l te, h rşut zm, akne, c ltte yağlanma ve saç dökülmes daha fazla, Ferr man-Gallwey Skoru (FGS) daha yüksek, adetler arası süre daha uzundu (bütün değ şkenlerde p <0,05). PKOS'lu kadınlarda; LH, Serbest testesteron, toplam testesteron, DHEA-SO4, açlık nsül n, HOMA-IR ve copept n düzeyler le nsül n d renc oranı yüksek saptandı (bütün değ şkenlerde p <0,05). Serum copept n düzey azalan sırayla HOMA-IR, açlık nsül n, AMH, toplam testesteron, serbest testesteron ve LH düzey yle poz t f korele saptandı (sırasıyla p1:
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