Monika Jangra
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Papers by Monika Jangra
stimuli-responsive polymers are having advantage over conventional chemotherapeutic agents with very less side effects, high concentration at tumor site, and
improved efficiency in the treatment of cancer. Cancer chemotherapy have a lot of
disadvantages such as systemic toxicity, non-specificity, low concentration in
tumor site, and ubiquitous biodistribution. At the time of cancer treatment,
multiple changes occur in different body parts simultaneously. To mimic such
changes in biological processes, stimuli-responsive polymers are required to
sense and respond toward these changes in a particular manner. Stimuliresponsive polymers have property to mimic and recognize changes of biological
processes for targeting the specific cancer cells. In continuation of this, stimuliresponsive polymers act at site either simultaneously or in a step-by-step manner to initiate the drug from its very first step to reach the cancer cell. In last decades,
polymers are extremely use in target specific drug delivery to inactivate or kill
cancerous cells. In continuation of this, a number of endogenous stimuliresponsive polymers (redox-, pH-, enzyme-responsive polymers) and exogenous
stimuli-responsive polymers (temperature, light) proved helpful in drug delivery.
The present chapter depicts about the stimuli-responsive polymers as well as
multi-responsive polymers and their significant role with respect to drug delivery
system in the treatment of cancer.
stimuli-responsive polymers are having advantage over conventional chemotherapeutic agents with very less side effects, high concentration at tumor site, and
improved efficiency in the treatment of cancer. Cancer chemotherapy have a lot of
disadvantages such as systemic toxicity, non-specificity, low concentration in
tumor site, and ubiquitous biodistribution. At the time of cancer treatment,
multiple changes occur in different body parts simultaneously. To mimic such
changes in biological processes, stimuli-responsive polymers are required to
sense and respond toward these changes in a particular manner. Stimuliresponsive polymers have property to mimic and recognize changes of biological
processes for targeting the specific cancer cells. In continuation of this, stimuliresponsive polymers act at site either simultaneously or in a step-by-step manner to initiate the drug from its very first step to reach the cancer cell. In last decades,
polymers are extremely use in target specific drug delivery to inactivate or kill
cancerous cells. In continuation of this, a number of endogenous stimuliresponsive polymers (redox-, pH-, enzyme-responsive polymers) and exogenous
stimuli-responsive polymers (temperature, light) proved helpful in drug delivery.
The present chapter depicts about the stimuli-responsive polymers as well as
multi-responsive polymers and their significant role with respect to drug delivery
system in the treatment of cancer.