To evaluate the circulating levels of adipokines (leptin and adiponectin) and ghrelin in patients... more To evaluate the circulating levels of adipokines (leptin and adiponectin) and ghrelin in patients with familial Mediterranean fever (FMF) and also to assess the relationships between these molecules and disease-related parameters. Forty-eight FMF patients in attack-free period (31 men, [M], 17 women, [F], mean age 35.8 § 8.6 years, and a mean body mass index [BMI] of 24.7 § 3.1) and 40 age-, sex-, and BMI-matched healthy controls (24 M, 16 F, mean age 35.5 § 8.5 years, and a mean BMI of 24.5 § 2.8) were included in the study. Patients and controls with a history of any other chronic diseases and obese or underweight subjects were excluded. High-sensitive C-reactive protein (hs-CRP), leptin, adiponectin, and total ghrelin concentrations were studied. Age, sex, BMI, waist circumference, and smoking status were similar between FMF patients and controls (P > 0.05). Adipose tissue-derived molecules including leptin, and adiponectin were lower than healthy controls but only adiponectin levels reached the statistically signiWcance (16.7 § 8.9 ng/ml vs. 27.7 § 15.9 ng/ml, P < 0.001) and leptin concentrations just missed signiWcance (25.2 § 16.2 ng/ml vs. 34.9 § 27.2 ng/ml, P = 0.051). Ghrelin concentrations were not diVerent between the groups. Adiponectin levels were signiWcantly and negatively correlated with hs-CRP (P < 0.05, r = ¡0.24). The results of this study suggest that low-grade chronic inXammation during attack-free period in FMF patients may suppress adiponectin production or low levels of adiponectin might contribute to subclinical inXammation in these patients.
To evaluate the circulating levels of adipokines (leptin and adiponectin) and ghrelin in patients... more To evaluate the circulating levels of adipokines (leptin and adiponectin) and ghrelin in patients with familial Mediterranean fever (FMF) and also to assess the relationships between these molecules and disease-related parameters. Forty-eight FMF patients in attack-free period (31 men, [M], 17 women, [F], mean age 35.8 § 8.6 years, and a mean body mass index [BMI] of 24.7 § 3.1) and 40 age-, sex-, and BMI-matched healthy controls (24 M, 16 F, mean age 35.5 § 8.5 years, and a mean BMI of 24.5 § 2.8) were included in the study. Patients and controls with a history of any other chronic diseases and obese or underweight subjects were excluded. High-sensitive C-reactive protein (hs-CRP), leptin, adiponectin, and total ghrelin concentrations were studied. Age, sex, BMI, waist circumference, and smoking status were similar between FMF patients and controls (P > 0.05). Adipose tissue-derived molecules including leptin, and adiponectin were lower than healthy controls but only adiponectin levels reached the statistically signiWcance (16.7 § 8.9 ng/ml vs. 27.7 § 15.9 ng/ml, P < 0.001) and leptin concentrations just missed signiWcance (25.2 § 16.2 ng/ml vs. 34.9 § 27.2 ng/ml, P = 0.051). Ghrelin concentrations were not diVerent between the groups. Adiponectin levels were signiWcantly and negatively correlated with hs-CRP (P < 0.05, r = ¡0.24). The results of this study suggest that low-grade chronic inXammation during attack-free period in FMF patients may suppress adiponectin production or low levels of adiponectin might contribute to subclinical inXammation in these patients.
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