Papers by Olof Pettersson
Endocrine Connections, 2021
Background Monitoring of pancreatic neuroendocrine tumors (PanNET) undergoing peptide receptor ra... more Background Monitoring of pancreatic neuroendocrine tumors (PanNET) undergoing peptide receptor radionuclide therapy (PRRT) with 177Lu-DOTATATE depends on changes in tumor size, which often occur late. Tumor growth rate (TGR) allows for quantitative assessment of the tumor kinetics expressed as %/month. We explored how TGR changes before and during/after PRRT and evaluated TGR as a biomarker for progression-free survival (PFS). Methods In PanNET patients undergoing PRRT with 177Lu-DOTATATE from 2006 to 2018, contrast-enhanced CT or MRI was performed before and during the therapy. Patients with at least one hypervascular liver metastasis were included. TGR was calculated for the period preceding treatment and for two intervals during/after PRRT. Cox regression was used for the survival analysis. Results Sixty-seven patients (43 men, 24 women), median age 60 years (range 29–77), median Ki-67 10% (range 1–30) were included. TGR before baseline (n = 57) (TGR0) was mean (s.d.) 6.0%/month ...
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Plato’s Protagoras, 2016
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Forutsattningarna for att skriva klarsprak kan variera fran organisation till organisation. Syfte... more Forutsattningarna for att skriva klarsprak kan variera fran organisation till organisation. Syftet med denna uppsats ar att undersoka organisationsspecifika forutsattningar for tillampning av klars ...
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I Sverige ar det lag pa att myndigheter ska kommunicera vardat, enkelt och begripligt. Arbetet me... more I Sverige ar det lag pa att myndigheter ska kommunicera vardat, enkelt och begripligt. Arbetet med att utifran dessa kriterier gora samspelet mellan myndigheter och medborgare sa effektivt som mojl ...
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Ancient Philosophy, 2021
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Epoché: A Journal for the History of Philosophy, 2018
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Polis: The Journal for Ancient Greek and Roman Political Thought, 2020
Together with the Sophist, Plato’s Statesman is often taken to introduce and develop a new scient... more Together with the Sophist, Plato’s Statesman is often taken to introduce and develop a new scientific form of theoretical inquiry, represented by the Eleatic visitor. This paper draws on recent scholarship on the Sophist and evaluates the reliability of this scientific approach when applied to political matters in the Statesman. It analyzes how the Eleatic visitor identifies and tries to mend two central mistakes in his own initial definition of the statesman and argues that the visitor’s treatment of three related topics – eugenics, tyranny and law – makes his line of reasoning inconsistent. Relying on Plato’s dramatic use of similar forms of argumentation elsewhere, it suggests that the Statesman is not designed to defend the political significance of the visitor’s new form of scientific philosophy, but that its purpose instead is to test and to critically examine the consequences of this line of inquiry.
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Frontiers in Oncology, 2020
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Scripta Instituti Donneriani Aboensis, 1987
The fact that a word or concept has been borrowed from outside does not mean that the original co... more The fact that a word or concept has been borrowed from outside does not mean that the original content, the original ideas which the loan word in question expresses, have also been adopted. This is by no means the case when it is a question of abstract words and notions, such as the afterlife. A word, an idea, a custom is taken over but filled with new content; in its new context it acquires a genuinely Saami conceptual load, which has its original domiciliary rights in Saami, north Eurasian culture. The present brief notes on the Nordic and Christian influence on Saami ideas about the realm of the dead proceed from the Saami religion as a whole, examining and explaining it from an external perspective: what connecting-points are there in the "original" mother tradition for the new ideas which have been adopted over the course of time and which have been grafted on to the old? The first and fundamental starting-point for the study of the meeting of the Saami religion with ...
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Scripta Instituti Donneriani Aboensis, 1967
Ruanda and Urundi belong to the Ruanda cluster of the interlactustrine Bantu in the regions surro... more Ruanda and Urundi belong to the Ruanda cluster of the interlactustrine Bantu in the regions surrounded by a great ring of lakes—Tanganyika, Kivu, Edward Albert, Kioga and Victoria. Pygmoid hunters and gatherers still survive among some tribes of the Ruanda cluster, and in both Ruanda and Urundi, people of "Hamitic" (Nilotic) origin live side by side with the original tribes. Most of the societies today reveal a sharp stratification into endogamous castes with a ruling aristocracy of herders called Tutsi, a subject agricultural peasanty called Hutu, and often also a depressed caste of Pygmy hunters, called Twa. Even if the beliefs in Ruanda and in Urundi differ in detail, the general religious system is the same among the both peoples. The influences—good or evil—on the life of mankind, on the social orders etc. come from what can be determined as the ultrahuman or superhuman' part of the world.
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Scripta Instituti Donneriani Aboensis, 1969
The study of primitive peoples has often neglected influences from the environments. The sociolog... more The study of primitive peoples has often neglected influences from the environments. The sociologists and the anthropologists regard the influence as a concrete fact that is taken in account with regard to the behaviour. They have—as a rule—no interest in studying the historical development. They take facts as they meet them in life. Studying African religions we must bear in mind that the influences of missions, for example Christian and Muslim, are clear among many of the African peoples. Therefore a study of foreign influences upon African religions is necessary in order to provide an analysis and an understanding of the contemporary religious situation. The purpose of this paper is to analyze the impact of foreign religions on the God-idea in order to see if the Christian or Muslim ideas of God are reflected in the indigenous religions of Africa.
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Journal of Ancient Philosophy, 2016
Against the background of a conventionalist theory, and staged as a defense of a naturalistic not... more Against the background of a conventionalist theory, and staged as a defense of a naturalistic notion of names and naming, the critique of language developed in Plato’s Cratylus does not only propose that human language, in contrast to the language of the gods, is bound to the realm of myth and lie. The dialogue also concludes by offering a set of reasons to think that knowledge of reality is not within the reach of our words. Interpretations of the dialogue’s long etymological sections often neglect this critique and tend to end up with an overly optimistic assessment of the theory of language on offer. In the light of one of the dialogue’s central etymological accounts, Socrates’ etymology of the name Hermes, this paper discusses two recent and influential versions of such a view: David Sedley’s theory of onomatopoetic encapsulation and Franco Trivigno’s qualified referentialism. It argues that the complex relation between language and reality expressed in the Cratylus cannot be ex...
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Vart satt att ta till oss nyheter forandras allt mer under digital medias framfart. Informationsf... more Vart satt att ta till oss nyheter forandras allt mer under digital medias framfart. Informationsflodet ar idag snabbare an nagonsin tidigare och anvandandet avelektroniska verktyg som surfplattor b ...
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Frontiers of Philosophy in China, Dec 5, 2013
In the Timaeus, Plato makes a distinction between reason and necessity. This distinction is often... more In the Timaeus, Plato makes a distinction between reason and necessity. This distinction is often accounted for as a distinction between two types of causation: purpose oriented causation and mechanistic causation. While reason is associated with the soul and taken to bring about its effects with the good and the beautiful as the end, necessity is understood in terms of a set of natural laws pertaining to material things. In this paper I shall suggest that there are reasons to reconsider the latter part of this account and argue for a non-mechanistic understanding of necessity. I will first outline how the notion of necessity is introduced in the dialogue. Next I will show how a mechanistic account of necessity fails to capture Plato’s purpose of treating it as a causal factor; and, finally, I will argue that this purpose is better understood as an attempt, on Plato’s part, to account for the causal origin of disorder and irrationality, an origin articulated in terms of a pre-cosmic situation and the notoriously difficult notion of the third kind.
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Nucleic acids research, Jan 27, 2015
Myotonic dystrophy type 1 is caused by abnormal expansion of a CTG-trinucleotide repeat in the ge... more Myotonic dystrophy type 1 is caused by abnormal expansion of a CTG-trinucleotide repeat in the gene encoding Dystrophia Myotonica Protein Kinase (DMPK), which in turn leads to global deregulation of gene expression in affected individuals. The transcribed mRNA contains a massive CUG-expansion in the 3' untranslated region (3'UTR) facilitating nucleation of several regulatory RNA-binding proteins, which are thus unable to perform their normal cellular function. These CUG-expanded mRNA-protein aggregates form distinct, primarily nuclear foci. In differentiated muscle cells, most of the CUG-expanded RNA remains in the nuclear compartment, while in dividing cells such as fibroblasts a considerable fraction of the mutant RNA reaches the cytoplasm, consistent with findings that both nuclear and cytoplasmic events are mis-regulated in DM1. Recent evidence suggests that the nuclear aggregates, or ribonuclear foci, are more dynamic than previously anticipated and regulated by several...
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Papers by Olof Pettersson