Cu–Mn–Ce–O composites with enhanced surface area and developed mesoporosity were synthesized usin... more Cu–Mn–Ce–O composites with enhanced surface area and developed mesoporosity were synthesized using a homogeneous coprecipitation (hcp) method, and were tested in the catalytic destruction of chlorobenzene (CB). X-ray diffraction (XRD), N2 adsorption/desorption, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), temperature programmed reduction (H2-TPR), temperature programmed desorption of CB/O2 (CB/O2-TPD), and diffuse reflectance ultraviolet visible spectroscopy (DRUV-Vis) were used to characterize the structure and textural properties of catalysts. Mn and Cu enter CeO2 matrix with a fluorite-like structure, and produce large amounts of oxygen vacancies. Addition of manganese promotes the formation of reduced copper phase, and the presence of large numbers of high valence Mn4+ ions strongly enhances the redox couple of Cu+–Cu2+ in the composites. Both the synthesis protocol and metal doping amount s...
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
To study the effects of Qingdai compound on proliferation and apoptosis of K562 cells, as well as... more To study the effects of Qingdai compound on proliferation and apoptosis of K562 cells, as well as the expression of bcr/abl and JWA mRNA, K562 cells were treated in culture with different concentrations of Qingdai compound (2.5, 5, 7.5, 10 and 20 mg/ml) and harvested at 24 hours. Then morphological changes were observed by light microscopy (LM); expressions of bcr/abl and JWA were detected with semi-quantitative RT-PCR. The results showed that morphological changes were observed as the increment of the Qingdai compound concentration. Inhibition effects on proliferation and apoptosis in K562 cells were seen. A concentration-dependent decreases were found in bcr-abl and JWA mRNA expression of K562 cells. Qingdai compound partially inhibited proliferation and induced apoptosis of K562 cells. Expressions of both bcr/abl and JWA, which took part in cell proliferation and apoptosis, were down-regulated in a dose dependent manner. In conclusion, Qingdai compound can partially inhibit the e...
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
The objective of this study was to explore the differences between refractory anemia with ringed ... more The objective of this study was to explore the differences between refractory anemia with ringed sideroblast (RARS) and RARS associated with marked thrombocytosis (RARS-T) in the clinical, biological features and prognosis. The morphological changes of cells were observed by bone marrow smear and biopsy. Immunologic phenotype was analyzed by flow cytometry, and chromosome was examined by conventional chromosomal analysis. JAK2 V617F and MPL W515L mutations were screened by allele-specific polymerase chain reaction (AS-PCR) and sequence analysis. The results showed that this case was clinically diagnosed as RARS with thrombophilia, the level of serum potassium was positively related with platelet counts. When platelets increased, the clusters of atypical giant platelets and megakaryocytes were observed in peripheral blood and bone marrow examined by bone marrow smear and bone marrow biopsy respectively, JAK2 V617F and MPL W515L mutations were negative. It is concluded that RARS may t...
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
This study was aimed to investigate the clinical, pathological and biological features of a speci... more This study was aimed to investigate the clinical, pathological and biological features of a special case of chronic myeloid leukemia (CML) with marked thrombocythemic onset. The morphological changes of cells were analyzed by using bone marrow smear and biopsy; Ph chromosome, a specific marker of CML, was assayed by conventional chromosomal analysis and fluorescence in situ hybridization, bcr/abl fusion gene was detected by reverse transcription-polymerase chain reaction. The results indicated that CML mimicked essential thrombocythemia (ET) at presentation was relatively rare and might be misdiagnosed as ET, bone marrow smear and biopsy revealed, marked thrombocytosis and moderate leukocytosis; RT-PCR, FISH and conventional chromosomal analysis demonstrated the existence of Ph chromosome and bcr/abl fusion gene. This special CML could progress into accelerated phase or blast crisis. The megakaryocytes in Ph+ ET were smaller than normal ones and had typically hypolobulated round nuc...
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
To explore the effects and the molecular mechanism of puerariae radix flavones (PRF) on acute mye... more To explore the effects and the molecular mechanism of puerariae radix flavones (PRF) on acute myeloid leukemia cell line Kasumi-1 cells in vitro. Kasumi-1 cells treated by PRF for 48 hours were observed with Wright's and Hoechst 33258 dying. The apoptotic cells were analyzed by flow cytometry with AnnexinV/PI staining. The expression levels of bcl-2, Bim and Caspase-3/-8/-9 protein were assayed by Western blot and the AML1-ETO fusion gene was detected by real-time polymerase chain reaction. PRF could induce Kasumi-1 cells to apoptosis effectively. The proportion of apoptotic cells in 50, 200 and 500 µg/ml PRF treatment groups were (14.1 ± 0.8)%, (17.7 ± 1.3)% and (32.4 ± 1.4)%, respectively, and significantly higher than that of control \[(7.8 ± 0.7)%\]. The relative expression levels of the anti-apoptotic Bcl-2 protein were 0.85 ± 0.05, 0.62 ± 0.07 and 0.43 ± 0.05; the apoptotic Bim protein were 0.21 ± 0.06, 0.39 ± 0.04 and 0.75 ± 0.05; the caspase-3 and caspase-9 were 0.92 ± 0...
Image Reconstruction from Incomplete Data IV, 2006
X-ray coherent diffractive imaging is attracting interest within the x-ray community because it p... more X-ray coherent diffractive imaging is attracting interest within the x-ray community because it promises wavelength-limited resolution for imaging nonperiodic objects. It is well known that a wave diffracted or scattered by an object can be described simply by the Fourier transform of the object's electron density distribution. However, this result is general only in the so-called far-field regime, where most
Transmission x-ray microscope (TXM) is a powerful imaging tool that can provide resolution down t... more Transmission x-ray microscope (TXM) is a powerful imaging tool that can provide resolution down to 15˜20 nm. Grating interferometer (GI) is a recently established imaging technique with which both phase and attenuation information of an arbitrary specimen can be extracted in a straightforward way. The achievable resolution of a GI is limited by either the grating analyzer period or the
ABSTRACT In this study, monometallic Co-mordenite (MOR) and bimetallic CoFe-MOR catalysts were pr... more ABSTRACT In this study, monometallic Co-mordenite (MOR) and bimetallic CoFe-MOR catalysts were prepared via simple wet ion exchange and tested for N2O decomposition. Strong promotion effect of Fe on the activity and stability of Co ions in the zeolites was observed. To investigate the origin of this promotion effect, X-ray diffraction, H2-temperature programmed reduction, UV-Vis spectroscopy, extended X-ray absorption fine structure analysis, and N2O temperature-programmed desorption were used to characterize the bimetallic and monometallic catalysts. The characteristic results indicated that higher contents of Co ions located at β sites after Fe addition provided cooperation on N2O splitting by two neighboring Co ions. Consequently, a greater amount of surface NOx species were formed in situ and were more strongly bonded to the catalyst, facilitating the removal of O and increasing the activity. Moreover, extended X-ray absorption fine structure analysis indicated that β-type Co ions exhibited stronger coordination to framework oxygen after Fe addition, and higher exchange level was obtained in the bimetallistic CoFe-MOR. Both of them contribute to prevent the relocation of Co2+ ions to form cobalt oxides, thus, high activity was maintained. Consequently, the CoFe-MOR catalyst demonstrates a superior catalytic activity and a high durability in N2O decomposition, showing great potential as a cost-effective catalyst for N2O elimination in future applications.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, 2005
The study was aimed to explore the role of gene JWA, a novel retinoic acid responsible and cytosk... more The study was aimed to explore the role of gene JWA, a novel retinoic acid responsible and cytoskeleton associate gene, in regulating committed differentiation of HL-60 cell and the molecular mechanism in the course of differentiation and apoptosis of leukemic cells. By using FCM, the changes of CD13, CD14, CD15, CD11b and cell cycles were detected in HL-60 cells treated with ATRA (10(-6) mol/L), Ara-C (10 ng/ml) and TPA (10(-8) mol/L) respectively. The samples were determined by semi-quantitative reverse transcript-polymerase chain reaction (RT-PCR) and Western blot for the expression of JWA, Bcl-2, HSP27 and HSP70 at day 0, 2, 4, 6, 8. The results showed that HL-60 cells committedly differentiated into granulocyte-, monocyte-, macrophage-like cells. As a result, JWA was up-regulated in a time-dependent manner, while Bcl-2 was down- regulated at the same time. In ATRA and TPA group, the change of HSP70 had positive correlation with JWA, and negative correlation with Bcl-2. The expr...
Medical oncology (Northwood, London, England), 2012
Here, we report a Philadelphia chromosome-positive chronic myeloid leukemia case with the longest... more Here, we report a Philadelphia chromosome-positive chronic myeloid leukemia case with the longest chronic phase and overall survival to our knowledge ever reported in the medical literature. During the 33-year chronic phase, he was asymptomatic without any treatment and had normal blood cell values. BCR-ABL silencing might be referred to the uncommon long-term survivor.
ABSTRACT A series of Co exchanged zeolites with ZSM-5, BEA, MOR and USY structures were prepared ... more ABSTRACT A series of Co exchanged zeolites with ZSM-5, BEA, MOR and USY structures were prepared and investigated for N2O catalytic decomposition under identical reaction conditions. It is found that Co-zeolites with different structures show dramatically different catalytic activities, which could be attributed to various Co species formed in them. Co-ZSM-5, Co-BEA and Co-MOR exhibit much higher activities than Co-USY catalysts, which is attributed to the predominant formation of active isolated Co2+ ions in the ion exchange positions; while in Co-USY Co mainly exists as less active Co oxides. Moreover, it is observed that the activities of Co2+ ions in ZSM-5, BEA and MOR zeolites are quite different and are related to the specific Co ion sites presented in each zeolite structure. In Co-ZSM-5, the most active sites are the α-type Co ions, which are weakly coordinated to framework oxygens in the straight channel. On the other hand, in Co-BEA and Co-MOR, the most active sites are β-type Co ions, which are coordinated to the framework oxygens of the elongated six-membered ring of BEA and the interconnected small channel of MOR, respectively. The main factors affecting the activities of these individual Co ions are indicated to be their location in the zeolite structure, their chemical coordination and the distances between the Co ions. The highest activity of the α-type Co ions in ZSM-5 could be attributed to their favorite location in the zeolite and weak coordination to framework oxygens, which make them easily accessible and coordinated to reactants. The large number of β-sites and their structural arrangement in MOR allow the formation of two unique adjacent β-Co ions in Co–Co pairs, which cooperate in N2O splitting, consequently yielding the high activity of β-Co ions in MOR.
Advances in Computational Methods for X-Ray Optics II, 2011
ABSTRACT Partially-coherent wavefront propagation calculations have proven to be feasible and ver... more ABSTRACT Partially-coherent wavefront propagation calculations have proven to be feasible and very beneficial in the design of beamlines for 3rd and th generation Synchrotron Radiation (SR) sources. These types of calculations use the framework of classical electrodynamics for the description, on the same accuracy level, of the emission by relativistic electrons moving in magnetic fields of accelerators, and the propagation of the emitted radiation wavefronts through beamline optical elements. This enables accurate prediction of performance characteristics for beamlines exploiting high SR brightness and/or high spectral flux. Detailed analysis of radiation degree of coherence, offered by the partially-coherent wavefront propagation method, is of paramount importance for modern storage-ring based SR sources, which, thanks to extremely small sub-nanometer-level electron beam emittances, produce substantial portions of coherent flux in X-ray spectral range. We describe the general approach to partially-coherent SR wavefront propagation simulations and present examples of such simulations performed using 'Synchrotron Radiation Workshop' (SRW) code for the parameters of hard X-ray undulator based beamlines at the National Synchrotron Light Source II (NSLS-II), Brookhaven National Laboratory. These examples illustrate general characteristics of partially-coherent undulator radiation beams in low-emittance SR sources, and demonstrate advantages of applying high-accuracy physical-optics simulations to the optimization and performance prediction of X-ray optical beamlines in these new sources.
ABSTRACT SBA-16 silica with intact surface hydroxyl groups was quickly obtained (5 min) via a fas... more ABSTRACT SBA-16 silica with intact surface hydroxyl groups was quickly obtained (5 min) via a fast-microwave-assisted method, and further adopted as an efficient template for the synthesis of three-dimensional (3D) ordered mesoporous CuOx-CeO2 catalysts (htpCCx) through a simple and reproducible host-guest interaction. XRD, XPS, H2-TPR, and Raman results reveal that many of the Cu2+ ions in htpCCx are incorporated into the CeO2 lattice, leading to the formation of a CuxCe1−xO2−δ solid solution, which produces a large number of oxygen vacancies and enhances the reducibility of the metal. The interaction of Cu and Ce is essential to the reaction as it maintains the Cu2+/Cu1+ and Ce4+/Ce3+ redox couples. The catalyst has a 3D mesostructure and possesses remarkably enhanced low-temperature activity for the combustion of epichlorohydrin. HtpCC20 has been identified as the most powerful catalyst for this reaction, with the reaction rate at 165 °C being about 6.3 and 33.3 times higher than those of catalysts synthesized using conventional incipient impregnation and thermal combustion methods, respectively. Furthermore, htpCC20 shows superior CO2 selectivity (>99%) and stability (no deactivation occurs after 50 h reaction). It is believed that the dispersion of the active phase, density of surface active oxygen, and low-temperature reducibility are the dominant factors governing the catalytic performance.
ABSTRACT Pure ceria catalysts were prepared by a facile modified homogeneous co-precipitation met... more ABSTRACT Pure ceria catalysts were prepared by a facile modified homogeneous co-precipitation method, and their catalytic performance was evaluated in the soot oxidation reaction. The structure and textural properties of the synthesized catalysts were characterized via XRD, N2 adsorption/desorption, TG-DSC-MS, H2-TPR, FE-SEM, HR-TEM and XPS techniques. It is shown that CeO2 samples prepared by the improved co-precipitation method exhibit obviously better catalytic activity than those prepared by the conventional co-precipitation method. The CeO2-CP4-F sample shows the best activity, for which the peak temperature, Tp, values of soot combustion are about 465 °C in O2 stream gas and 430 °C in a NO/O2 stream under soot/catalyst “loose contact” conditions. Moreover, after high temperature aging, the activity of CeO2-CP4-A becomes even better, for which the Tp value of soot combustion is lowered to 445 °C in O2 air gas. The catalytic activity is not well associated with the physicochemical properties of BET surface area, particle size and reducibility at low temperatures. The number of lattice oxygen and its mobility in the series of CeO2 may be the crucial factor to decide the overall catalytic performance. According to the HRTEM result, the excellent migration of lattice oxygen may result from the preferential exposure of more-reactive planes, which may be the essential reason to explain the good performance of CeO2 catalysts in soot oxidation.
Synchrotron radiation (SR) has become an essential and rapidly growing tool across the sciences a... more Synchrotron radiation (SR) has become an essential and rapidly growing tool across the sciences and engineering. World-wide, about 70 SR sources are in various stages of operation, construction, or planning, representing a cumulative investment on many billions of dollars and serving a growing research community well in excess of 10,000 scientists. To date, all major SR x-ray facilities are based
Cu–Mn–Ce–O composites with enhanced surface area and developed mesoporosity were synthesized usin... more Cu–Mn–Ce–O composites with enhanced surface area and developed mesoporosity were synthesized using a homogeneous coprecipitation (hcp) method, and were tested in the catalytic destruction of chlorobenzene (CB). X-ray diffraction (XRD), N2 adsorption/desorption, field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), temperature programmed reduction (H2-TPR), temperature programmed desorption of CB/O2 (CB/O2-TPD), and diffuse reflectance ultraviolet visible spectroscopy (DRUV-Vis) were used to characterize the structure and textural properties of catalysts. Mn and Cu enter CeO2 matrix with a fluorite-like structure, and produce large amounts of oxygen vacancies. Addition of manganese promotes the formation of reduced copper phase, and the presence of large numbers of high valence Mn4+ ions strongly enhances the redox couple of Cu+–Cu2+ in the composites. Both the synthesis protocol and metal doping amount s...
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
To study the effects of Qingdai compound on proliferation and apoptosis of K562 cells, as well as... more To study the effects of Qingdai compound on proliferation and apoptosis of K562 cells, as well as the expression of bcr/abl and JWA mRNA, K562 cells were treated in culture with different concentrations of Qingdai compound (2.5, 5, 7.5, 10 and 20 mg/ml) and harvested at 24 hours. Then morphological changes were observed by light microscopy (LM); expressions of bcr/abl and JWA were detected with semi-quantitative RT-PCR. The results showed that morphological changes were observed as the increment of the Qingdai compound concentration. Inhibition effects on proliferation and apoptosis in K562 cells were seen. A concentration-dependent decreases were found in bcr-abl and JWA mRNA expression of K562 cells. Qingdai compound partially inhibited proliferation and induced apoptosis of K562 cells. Expressions of both bcr/abl and JWA, which took part in cell proliferation and apoptosis, were down-regulated in a dose dependent manner. In conclusion, Qingdai compound can partially inhibit the e...
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
The objective of this study was to explore the differences between refractory anemia with ringed ... more The objective of this study was to explore the differences between refractory anemia with ringed sideroblast (RARS) and RARS associated with marked thrombocytosis (RARS-T) in the clinical, biological features and prognosis. The morphological changes of cells were observed by bone marrow smear and biopsy. Immunologic phenotype was analyzed by flow cytometry, and chromosome was examined by conventional chromosomal analysis. JAK2 V617F and MPL W515L mutations were screened by allele-specific polymerase chain reaction (AS-PCR) and sequence analysis. The results showed that this case was clinically diagnosed as RARS with thrombophilia, the level of serum potassium was positively related with platelet counts. When platelets increased, the clusters of atypical giant platelets and megakaryocytes were observed in peripheral blood and bone marrow examined by bone marrow smear and bone marrow biopsy respectively, JAK2 V617F and MPL W515L mutations were negative. It is concluded that RARS may t...
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology
This study was aimed to investigate the clinical, pathological and biological features of a speci... more This study was aimed to investigate the clinical, pathological and biological features of a special case of chronic myeloid leukemia (CML) with marked thrombocythemic onset. The morphological changes of cells were analyzed by using bone marrow smear and biopsy; Ph chromosome, a specific marker of CML, was assayed by conventional chromosomal analysis and fluorescence in situ hybridization, bcr/abl fusion gene was detected by reverse transcription-polymerase chain reaction. The results indicated that CML mimicked essential thrombocythemia (ET) at presentation was relatively rare and might be misdiagnosed as ET, bone marrow smear and biopsy revealed, marked thrombocytosis and moderate leukocytosis; RT-PCR, FISH and conventional chromosomal analysis demonstrated the existence of Ph chromosome and bcr/abl fusion gene. This special CML could progress into accelerated phase or blast crisis. The megakaryocytes in Ph+ ET were smaller than normal ones and had typically hypolobulated round nuc...
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
To explore the effects and the molecular mechanism of puerariae radix flavones (PRF) on acute mye... more To explore the effects and the molecular mechanism of puerariae radix flavones (PRF) on acute myeloid leukemia cell line Kasumi-1 cells in vitro. Kasumi-1 cells treated by PRF for 48 hours were observed with Wright's and Hoechst 33258 dying. The apoptotic cells were analyzed by flow cytometry with AnnexinV/PI staining. The expression levels of bcl-2, Bim and Caspase-3/-8/-9 protein were assayed by Western blot and the AML1-ETO fusion gene was detected by real-time polymerase chain reaction. PRF could induce Kasumi-1 cells to apoptosis effectively. The proportion of apoptotic cells in 50, 200 and 500 µg/ml PRF treatment groups were (14.1 ± 0.8)%, (17.7 ± 1.3)% and (32.4 ± 1.4)%, respectively, and significantly higher than that of control \[(7.8 ± 0.7)%\]. The relative expression levels of the anti-apoptotic Bcl-2 protein were 0.85 ± 0.05, 0.62 ± 0.07 and 0.43 ± 0.05; the apoptotic Bim protein were 0.21 ± 0.06, 0.39 ± 0.04 and 0.75 ± 0.05; the caspase-3 and caspase-9 were 0.92 ± 0...
Image Reconstruction from Incomplete Data IV, 2006
X-ray coherent diffractive imaging is attracting interest within the x-ray community because it p... more X-ray coherent diffractive imaging is attracting interest within the x-ray community because it promises wavelength-limited resolution for imaging nonperiodic objects. It is well known that a wave diffracted or scattered by an object can be described simply by the Fourier transform of the object's electron density distribution. However, this result is general only in the so-called far-field regime, where most
Transmission x-ray microscope (TXM) is a powerful imaging tool that can provide resolution down t... more Transmission x-ray microscope (TXM) is a powerful imaging tool that can provide resolution down to 15˜20 nm. Grating interferometer (GI) is a recently established imaging technique with which both phase and attenuation information of an arbitrary specimen can be extracted in a straightforward way. The achievable resolution of a GI is limited by either the grating analyzer period or the
ABSTRACT In this study, monometallic Co-mordenite (MOR) and bimetallic CoFe-MOR catalysts were pr... more ABSTRACT In this study, monometallic Co-mordenite (MOR) and bimetallic CoFe-MOR catalysts were prepared via simple wet ion exchange and tested for N2O decomposition. Strong promotion effect of Fe on the activity and stability of Co ions in the zeolites was observed. To investigate the origin of this promotion effect, X-ray diffraction, H2-temperature programmed reduction, UV-Vis spectroscopy, extended X-ray absorption fine structure analysis, and N2O temperature-programmed desorption were used to characterize the bimetallic and monometallic catalysts. The characteristic results indicated that higher contents of Co ions located at β sites after Fe addition provided cooperation on N2O splitting by two neighboring Co ions. Consequently, a greater amount of surface NOx species were formed in situ and were more strongly bonded to the catalyst, facilitating the removal of O and increasing the activity. Moreover, extended X-ray absorption fine structure analysis indicated that β-type Co ions exhibited stronger coordination to framework oxygen after Fe addition, and higher exchange level was obtained in the bimetallistic CoFe-MOR. Both of them contribute to prevent the relocation of Co2+ ions to form cobalt oxides, thus, high activity was maintained. Consequently, the CoFe-MOR catalyst demonstrates a superior catalytic activity and a high durability in N2O decomposition, showing great potential as a cost-effective catalyst for N2O elimination in future applications.
Zhongguo shi yan xue ye xue za zhi / Zhongguo bing li sheng li xue hui = Journal of experimental hematology / Chinese Association of Pathophysiology, 2005
The study was aimed to explore the role of gene JWA, a novel retinoic acid responsible and cytosk... more The study was aimed to explore the role of gene JWA, a novel retinoic acid responsible and cytoskeleton associate gene, in regulating committed differentiation of HL-60 cell and the molecular mechanism in the course of differentiation and apoptosis of leukemic cells. By using FCM, the changes of CD13, CD14, CD15, CD11b and cell cycles were detected in HL-60 cells treated with ATRA (10(-6) mol/L), Ara-C (10 ng/ml) and TPA (10(-8) mol/L) respectively. The samples were determined by semi-quantitative reverse transcript-polymerase chain reaction (RT-PCR) and Western blot for the expression of JWA, Bcl-2, HSP27 and HSP70 at day 0, 2, 4, 6, 8. The results showed that HL-60 cells committedly differentiated into granulocyte-, monocyte-, macrophage-like cells. As a result, JWA was up-regulated in a time-dependent manner, while Bcl-2 was down- regulated at the same time. In ATRA and TPA group, the change of HSP70 had positive correlation with JWA, and negative correlation with Bcl-2. The expr...
Medical oncology (Northwood, London, England), 2012
Here, we report a Philadelphia chromosome-positive chronic myeloid leukemia case with the longest... more Here, we report a Philadelphia chromosome-positive chronic myeloid leukemia case with the longest chronic phase and overall survival to our knowledge ever reported in the medical literature. During the 33-year chronic phase, he was asymptomatic without any treatment and had normal blood cell values. BCR-ABL silencing might be referred to the uncommon long-term survivor.
ABSTRACT A series of Co exchanged zeolites with ZSM-5, BEA, MOR and USY structures were prepared ... more ABSTRACT A series of Co exchanged zeolites with ZSM-5, BEA, MOR and USY structures were prepared and investigated for N2O catalytic decomposition under identical reaction conditions. It is found that Co-zeolites with different structures show dramatically different catalytic activities, which could be attributed to various Co species formed in them. Co-ZSM-5, Co-BEA and Co-MOR exhibit much higher activities than Co-USY catalysts, which is attributed to the predominant formation of active isolated Co2+ ions in the ion exchange positions; while in Co-USY Co mainly exists as less active Co oxides. Moreover, it is observed that the activities of Co2+ ions in ZSM-5, BEA and MOR zeolites are quite different and are related to the specific Co ion sites presented in each zeolite structure. In Co-ZSM-5, the most active sites are the α-type Co ions, which are weakly coordinated to framework oxygens in the straight channel. On the other hand, in Co-BEA and Co-MOR, the most active sites are β-type Co ions, which are coordinated to the framework oxygens of the elongated six-membered ring of BEA and the interconnected small channel of MOR, respectively. The main factors affecting the activities of these individual Co ions are indicated to be their location in the zeolite structure, their chemical coordination and the distances between the Co ions. The highest activity of the α-type Co ions in ZSM-5 could be attributed to their favorite location in the zeolite and weak coordination to framework oxygens, which make them easily accessible and coordinated to reactants. The large number of β-sites and their structural arrangement in MOR allow the formation of two unique adjacent β-Co ions in Co–Co pairs, which cooperate in N2O splitting, consequently yielding the high activity of β-Co ions in MOR.
Advances in Computational Methods for X-Ray Optics II, 2011
ABSTRACT Partially-coherent wavefront propagation calculations have proven to be feasible and ver... more ABSTRACT Partially-coherent wavefront propagation calculations have proven to be feasible and very beneficial in the design of beamlines for 3rd and th generation Synchrotron Radiation (SR) sources. These types of calculations use the framework of classical electrodynamics for the description, on the same accuracy level, of the emission by relativistic electrons moving in magnetic fields of accelerators, and the propagation of the emitted radiation wavefronts through beamline optical elements. This enables accurate prediction of performance characteristics for beamlines exploiting high SR brightness and/or high spectral flux. Detailed analysis of radiation degree of coherence, offered by the partially-coherent wavefront propagation method, is of paramount importance for modern storage-ring based SR sources, which, thanks to extremely small sub-nanometer-level electron beam emittances, produce substantial portions of coherent flux in X-ray spectral range. We describe the general approach to partially-coherent SR wavefront propagation simulations and present examples of such simulations performed using 'Synchrotron Radiation Workshop' (SRW) code for the parameters of hard X-ray undulator based beamlines at the National Synchrotron Light Source II (NSLS-II), Brookhaven National Laboratory. These examples illustrate general characteristics of partially-coherent undulator radiation beams in low-emittance SR sources, and demonstrate advantages of applying high-accuracy physical-optics simulations to the optimization and performance prediction of X-ray optical beamlines in these new sources.
ABSTRACT SBA-16 silica with intact surface hydroxyl groups was quickly obtained (5 min) via a fas... more ABSTRACT SBA-16 silica with intact surface hydroxyl groups was quickly obtained (5 min) via a fast-microwave-assisted method, and further adopted as an efficient template for the synthesis of three-dimensional (3D) ordered mesoporous CuOx-CeO2 catalysts (htpCCx) through a simple and reproducible host-guest interaction. XRD, XPS, H2-TPR, and Raman results reveal that many of the Cu2+ ions in htpCCx are incorporated into the CeO2 lattice, leading to the formation of a CuxCe1−xO2−δ solid solution, which produces a large number of oxygen vacancies and enhances the reducibility of the metal. The interaction of Cu and Ce is essential to the reaction as it maintains the Cu2+/Cu1+ and Ce4+/Ce3+ redox couples. The catalyst has a 3D mesostructure and possesses remarkably enhanced low-temperature activity for the combustion of epichlorohydrin. HtpCC20 has been identified as the most powerful catalyst for this reaction, with the reaction rate at 165 °C being about 6.3 and 33.3 times higher than those of catalysts synthesized using conventional incipient impregnation and thermal combustion methods, respectively. Furthermore, htpCC20 shows superior CO2 selectivity (>99%) and stability (no deactivation occurs after 50 h reaction). It is believed that the dispersion of the active phase, density of surface active oxygen, and low-temperature reducibility are the dominant factors governing the catalytic performance.
ABSTRACT Pure ceria catalysts were prepared by a facile modified homogeneous co-precipitation met... more ABSTRACT Pure ceria catalysts were prepared by a facile modified homogeneous co-precipitation method, and their catalytic performance was evaluated in the soot oxidation reaction. The structure and textural properties of the synthesized catalysts were characterized via XRD, N2 adsorption/desorption, TG-DSC-MS, H2-TPR, FE-SEM, HR-TEM and XPS techniques. It is shown that CeO2 samples prepared by the improved co-precipitation method exhibit obviously better catalytic activity than those prepared by the conventional co-precipitation method. The CeO2-CP4-F sample shows the best activity, for which the peak temperature, Tp, values of soot combustion are about 465 °C in O2 stream gas and 430 °C in a NO/O2 stream under soot/catalyst “loose contact” conditions. Moreover, after high temperature aging, the activity of CeO2-CP4-A becomes even better, for which the Tp value of soot combustion is lowered to 445 °C in O2 air gas. The catalytic activity is not well associated with the physicochemical properties of BET surface area, particle size and reducibility at low temperatures. The number of lattice oxygen and its mobility in the series of CeO2 may be the crucial factor to decide the overall catalytic performance. According to the HRTEM result, the excellent migration of lattice oxygen may result from the preferential exposure of more-reactive planes, which may be the essential reason to explain the good performance of CeO2 catalysts in soot oxidation.
Synchrotron radiation (SR) has become an essential and rapidly growing tool across the sciences a... more Synchrotron radiation (SR) has become an essential and rapidly growing tool across the sciences and engineering. World-wide, about 70 SR sources are in various stages of operation, construction, or planning, representing a cumulative investment on many billions of dollars and serving a growing research community well in excess of 10,000 scientists. To date, all major SR x-ray facilities are based
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