Papers by Sérgio Talarico
Skinmed, Nov 1, 2005
This study was designed to describe the histologic aspects of the cutaneous and mucosal adverse r... more This study was designed to describe the histologic aspects of the cutaneous and mucosal adverse reactions to fillers used for cosmetic purposes. Methods and Materials. Eleven specimens of adverse reactions caused by Restylane, Artecoll, Metacril, New-Fill, Aquamid, and liquid silicone were processed and stained by hematoxylin-eosin and Alcian blue and submitted to polarized light. Results. Most of the reactions were foreign-body granulomas. Conclusions. The type of granuloma and the characteristics of the agent were determined, contributing to the histologic identification of the material used. In the cases involving Restylane and Aquamid, it was possible to identify the material using Alcian blue stain and by the presence of necrosis. This stain was strongly positive in Restylane and faintly positive in Aquamid, and intense necrosis was observed in Aquamid cases. In the other cases the filler material itself was recognized and identified.
Surgical and Cosmetic Dermatology, 2016
Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles. Treatment should ... more Acne vulgaris is a chronic inflammatory disease of the pilosebaceous follicles. Treatment should be early and effective to prevent scarring and psychosocial effects, and isotretinoin is the drug of choice for moderate or severe cases. Objective: To assess efficacy, safety and tolerability of an isotretinoin similar to the reference product. Methods: A bicentric study, with therapeutic intervention was conducted, including 50 participants aged 13 to 35 years, with moderate to severe acne, using isotretinoin 0.5 mg/kg/day up to 120 mg/ kg. Efficacy was assessed through lesions counting, the investigator’s global assessment (IGA) scale, patient satisfaction and application of the quality of life questionnaire specific for Acne (Acne Qol). Safety and tolerability were assessed by analysis of adverse events and laboratory tests. Results: Mean age was 20 years, 70% of participants were men, with a reduction of 99% of lesions after treatment and complete remission of lesions in 91.5% of participants. IGA scale reduced 98% in the score after treatment. Also, 100% of participants declared to be satisfied, with significant improvement in quality of life. Adverse events were similar to those described in the literature. Conclusion: The assessed isotretinoin was equally effective, safe and well-tolerated when compared with published data of the standard product
RBM rev. bras. med, 2008
... J Pharmacol Exp Ther 1978 206:661-9. 8. Rigoni M, Caccin P, Johnson EA, Montecucco C,Rossetto... more ... J Pharmacol Exp Ther 1978 206:661-9. 8. Rigoni M, Caccin P, Johnson EA, Montecucco C,Rossetto O. Site-directed mutagenesis identifies active-site residues of the light chain of botulinum neurotoxin type A. Biochemical and biophysical research communications 2001 288 ...
Anais Brasileiros De Dermatologia, Aug 1, 2005
Artigo de Revisão Resumo: A síndrome do ovário policístico é distúrbio endócrino feminino, extrem... more Artigo de Revisão Resumo: A síndrome do ovário policístico é distúrbio endócrino feminino, extremamente comum na idade reprodutiva. Caracteriza-se por anormalidades menstruais, hiperandrogenismo e/ou hiperandrogenemia. A principal alteração na fisiopatologia é desconhecida. Entretanto, parece que a resistência à insulina, o hiperandrogenismo e a alteração na dinâmica das gonadotropinas são os mais importantes mecanismos fisiopatológicos envolvidos. As características clínicas mais freqüentes da síndrome do ovário policístico estão relacionadas com a unidade pilossebácea, como hirsutismo, acne, seborréia e alopecia. Desse modo, o dermatologista pode ser responsável pelo diagnóstico precoce da síndrome, evitando o retardo na instituição de medidas terapêutico-preventivas. Atualmente, as drogas recomendadas para as manifestações cutâneas da síndrome do ovário policístico são os contraceptivos orais conjugados, antiandrógenos e sensibilizantes de insulina e, além disso, é geralmente recomendada a modificação no estilo de vida. Trata-se de artigo de revisão sobre diagnóstico, fisiopatologia e tratamento da síndrome do ovário policístico. Os autores enfatizam que o conhecimento da fisiopatologia dessa síndrome, principalmente pelos dermatologistas, é fundamental para seu tratamento preventivo, nas diferentes fases da vida da mulher. Palavras-chave: Hiperandrogenismo / diagnóstico; Hiperandrogenismo / terapia; Pele; Resistência à insulina; Sistema hipotálamo-hipofisário
Conflitos de interesse: Nenhum Suporte financeiro: Nenhum RESUMO Introdução: o uso da técnica de ... more Conflitos de interesse: Nenhum Suporte financeiro: Nenhum RESUMO Introdução: o uso da técnica de preenchimento cutâneo vem crescendo nos últimos anos. O ácido hialurônico é um dos preenchedores dérmicos temporários mais usados na correção de rugas, linhas e sulcos faciais por ser seguro e eficaz. Objetivo: avaliar a eficácia e segurança do produto Perfectha®, novo preenchedor à base de ácido hialurônico, para a correção dos sulcos nasolabiais e contorno dos lábios. Métodos: estudo aberto, multicêntrico, não randomizado, não controlado, incluindo 87 mulheres saudáveis. A avaliação da eficácia foi realizada através das escalas de melhora estética global (Global Aesthetic Improvement Scale-GAIS) e da classificação de gravidade das rugas (Wrinkle Severity Rating Scale-WSRS). A segurança foi avaliada por observação e relato de eventos adversos. Resultados: uma semana após a aplicação do preenchedor, foi observada melhora nos sulcos nasolabiais de 86% das mulheres e nos lábios de 89% delas. Reação inflamatória, transitória, leve ou moderada e equimoses ocorreram em 15% e 9% das pacientes, respectivamente, sobretudo nos sulcos nasolabiais. Duas pacientes apresentaram herpes simples labial após o tratamento dos lábios. Os bons resultados se mantiveram em 76% e 57% das mulheres, nos sulcos nasolabiais e em 72% e 45% delas nos lábios, após três e seis meses, respectivamente. Conclusão: o preenchedor Perfectha ® mostrou-se eficaz e seguro para essas indicações. Palavras-chave: ácido hialurônico; pele; inflamação.
Surgical and Cosmetic Dermatology, 2009
Introduction: The botulinum toxin is a valuable option for the treatment of dynamic facial wrinkl... more Introduction: The botulinum toxin is a valuable option for the treatment of dynamic facial wrinkles. The Lanzhou botulinum toxin type A (LBTX-A) was introduc...
International Journal of Dermatology, Aug 1, 2009
Background Chronically photodamaged skin usually presents with multiple, widespread, actinic kera... more Background Chronically photodamaged skin usually presents with multiple, widespread, actinic keratoses (AKs), and treatment of the entire affected area is recommended. Methods We report our experience with a combination of Jessner's solution or 70% glycolic acid (GA) with 5% 5-fluorouracil (5-FU) solution for superficial pulse peeling used in the treatment of widespread AKs in 31 patients. Pulse peelings were performed at biweekly intervals. The endpoint for treatment was complete or maximum clearance of the lesions at clinical evaluation. Pre-and post-skin biopsy and histopathologic examination were performed in three patients for the purpose of demonstrating the pulse peel effects. Results All patients achieved a satisfactory result, including the complete regression, or at least 80% clearing, of AK lesions and an overall improvement of photodamaged skin. Conclusion We consider this superficial 5-FU pulse peel to be a safe, well-tolerated, very effective, and highly inexpensive therapeutic option for the treatment of multiple, diffuse AKs. Its benefit/cost ratio will be of interest to public health services, mainly in developing countries.
1 Collaborating Dermatologist Physician, Dermatology Department, Cosmiatry, Surgery and Oncology ... more 1 Collaborating Dermatologist Physician, Dermatology Department, Cosmiatry, Surgery and Oncology Unit – Universidade Federal de São Paulo (Unifesp), Brazil. 2 Coordinator, of the discipline of dermatology, Universidade Federal do Vale do São Francisco – Petrolina (PE), Brazil; PhD candidate, Pathology Department, Universidade Federal de São Paulo (Unifesp); and Voluntary Collaborating Dermatologist Physician, Dermatology Department, Universidade Federal de São Paulo (Unifesp). 3 Collaborating Dermatologist Physician, Dermatology Department, Cosmiatry, Surgery and Oncology Unit – Universidade Federal de São Paulo (Unifesp). 4 Physician, Dermatology Department, Cosmiatry, Surgery and Oncology Unit – Universidade Federal de São Paulo (Unifesp). 5 Assistant Professor, Dermatology Department, Cosmiatry, Surgery and Oncology Unit – Universidade Federal de São Paulo (Unifesp). 6 Assistant Professor, Dermatology Department, Cosmiatry, Surgery and Oncology Unit – Universidade Federal de São ...
Conflitos de interesse: Nenhum Suporte financeiro: Nenhum RESUMO Introdução: o uso da técnica de ... more Conflitos de interesse: Nenhum Suporte financeiro: Nenhum RESUMO Introdução: o uso da técnica de preenchimento cutâneo vem crescendo nos últimos anos. O ácido hialurônico é um dos preenchedores dérmicos temporários mais usados na correção de rugas, linhas e sulcos faciais por ser seguro e eficaz. Objetivo: avaliar a eficácia e segurança do produto Perfectha®, novo preenchedor à base de ácido hialurônico, para a correção dos sulcos nasolabiais e contorno dos lábios. Métodos: estudo aberto, multicêntrico, não randomizado, não controlado, incluindo 87 mulheres saudáveis. A avaliação da eficácia foi realizada através das escalas de melhora estética global (Global Aesthetic Improvement Scale-GAIS) e da classificação de gravidade das rugas (Wrinkle Severity Rating Scale-WSRS). A segurança foi avaliada por observação e relato de eventos adversos. Resultados: uma semana após a aplicação do preenchedor, foi observada melhora nos sulcos nasolabiais de 86% das mulheres e nos lábios de 89% delas. Reação inflamatória, transitória, leve ou moderada e equimoses ocorreram em 15% e 9% das pacientes, respectivamente, sobretudo nos sulcos nasolabiais. Duas pacientes apresentaram herpes simples labial após o tratamento dos lábios. Os bons resultados se mantiveram em 76% e 57% das mulheres, nos sulcos nasolabiais e em 72% e 45% delas nos lábios, após três e seis meses, respectivamente. Conclusão: o preenchedor Perfectha ® mostrou-se eficaz e seguro para essas indicações. Palavras-chave: ácido hialurônico; pele; inflamação.
Journal of Cosmetic Dermatology, 2015
The wide use of cosmetics and their perceived benefits upon well-being imply objective descriptio... more The wide use of cosmetics and their perceived benefits upon well-being imply objective descriptions of their effects upon the different dimensions contributing to the quality of life (QoL). Such a goal pleas for using relevant and validated scientific instruments with robust measurement methods. This paper discusses the interest of the new validated questionnaire BeautyQoL specifically designed to assess the effect of cosmetic products on physical appearance and QoL. After conducting a review of skin appearance and QoL, three phases of the international codevelopment have been carried out in the following sequence: semi-directed interviews (Phase 1), acceptability study (Phase 2), and validation study (Phase 3). Data collection and validation process have been carried out in 16 languages. This review confirms that QoL instruments developed in dermatology are not suitable to assess cosmetic products, mainly because of their lack of sensitivity. General acceptability of BeautyQol was very good. Forty-two questions have been structured in five dimensions that explained 76.7% of the total variance: Social Life, Self-confidence, Mood, Vitality, and Attractiveness. Cronbach's alpha coefficients are between 0.932 and 0.978, confirming the good internal consistency of the results. The BeautyQol questionnaire is the first international instrument specific to cosmetic products and physical appearance that has been validated in 16 languages and could be used in a number of clinical trials and descriptive studies to demonstrate the added value of these products on the QoL.
International Journal of Dermatology, 2013
Oral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acn... more Oral isotretinoin (ISO) is the only drug which promotes prolonged remission or cure of severe acne. It also has other properties, supporting its use for non-acne indications. Retinoic acid (RA) is gold standard treatment for photoaging. ISO for photoaging treatment was reported in non-controlled trials as alternative to RA, which causes skin irritation. To compare clinical, histological, and immunohistochemical effects of low-dose ISO and 0.05% topical RA to treat photoaging. Randomized, comparative, evaluator-blinded, single-center study. Twenty-four healthy, Caucasian, 50 to 75-year-old men and women (menopausal or sterilized) with advanced photoaging were included. Twelve subjects received ISO, 20 mg/day, and 12 subjects were treated with RA cream, for six months; both treatments were administered every other day, and moisturizer and sunscreen were also used. Outcome measures included patient assessments, blinded photographic evaluations, Life Quality Index, histological (HE, Verhoeff) and immunohistochemical (p53, collagen type I) evaluations, adverse events, liver function, lipid profile, and blood count. Statistical analysis with generalized estimating equations and repeated measures ANOVA tests was used. Eleven subjects in each group completed the study. Patient and photographic assessments showed overall improvement in skin appearance. Quality-of-life scores were reduced for all subjects. Histological analysis revealed corneal layer diminution, epidermal thickness increase, and elastosis reduction. Immunohistochemical findings revealed significant epidermal p53 reduction and dermal collagen 1 increase. No differences were found between groups; laboratory tests showed no significant alterations. Despite being safe and effective, low-dose ISO was not superior to 0.05% RA for advanced photoaging treatment.
International Journal of Dermatology, 2009
Background Chronically photodamaged skin usually presents with multiple, widespread, actinic ker... more Background Chronically photodamaged skin usually presents with multiple, widespread, actinic keratoses (AKs), and treatment of the entire affected area is recommended.Methods We report our experience with a combination of Jessner’s solution or 70% glycolic acid (GA) with 5% 5‐fluorouracil (5‐FU) solution for superficial pulse peeling used in the treatment of widespread AKs in 31 patients. Pulse peelings were performed at biweekly intervals. The endpoint for treatment was complete or maximum clearance of the lesions at clinical evaluation. Pre‐ and post‐skin biopsy and histopathologic examination were performed in three patients for the purpose of demonstrating the pulse peel effects.Results All patients achieved a satisfactory result, including the complete regression, or at least 80% clearing, of AK lesions and an overall improvement of photodamaged skin.Conclusion We consider this superficial 5‐FU pulse peel to be a safe, well‐tolerated, very effective, and highly inexpensive ...
Archives of Dermatology, 2012
To develop a new quality-of-life (QoL) instrument with international validity that specifically a... more To develop a new quality-of-life (QoL) instrument with international validity that specifically assesses cosmetic products and physical appearance. Design: In the first phase, semidirected interviews involved 309 subjects. In the second stage, an acceptability study was performed on 874 subjects. Thereafter, we recruited a total of 3231 subjects, each of whom completed the BeautyQoL questionnaire, a clinical checklist for the skin, the generic QoL 36-Item Short Form Health Survey, and a sociodemographic questionnaire. A retest was performed 8 days later on a subgroup of 652 subjects.
Med Cutan Iber Lat …, 2006
... Fernando S. Macedo, Silvia Karina Kaminsky, Edileia Bagatin, Karine M. Hassun, Sergio Talaric... more ... Fernando S. Macedo, Silvia Karina Kaminsky, Edileia Bagatin, Karine M. Hassun, Sergio Talarico Department of Dermatology. ... During the first month they were oriented to only use a cream containing 10% glycolic acid and 4% hydroquinone as well as sun protector, on both ...
Surgical & Cosmetic Dermatology, 2016
2 Postgraduate degree in Dermatology. Dermatologist physician-Cascavel (PR), Brazil. 3 MSc in Der... more 2 Postgraduate degree in Dermatology. Dermatologist physician-Cascavel (PR), Brazil. 3 MSc in Dermatology. Dermatologist physician, UNIFESP.
International Journal of Dermatology, 2010
The laboratory diagnosis of syphilis depends mainly on two types of serology tests: (1) treponema... more The laboratory diagnosis of syphilis depends mainly on two types of serology tests: (1) treponemal tests which detect specific antit r e p o n e m a l a n t i b o d y s u c h a s e n z y m e immunoassay (TP EIA), Treponema pallidum particle agglutination (TPPA) test and fluorescent treponemal antibody absorption assay (FTA-abs); and (2) non-specific anti-lipoidal antibody like Venereal Disease Research Laboratory (VDRL) assay and rapid plasma regain (RPR) assay.
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Papers by Sérgio Talarico