Tagetes patula (Asteraceae) is a medicinal plant which is indigenous to Tropical America but cult... more Tagetes patula (Asteraceae) is a medicinal plant which is indigenous to Tropical America but cultivated in Pakistan. During the chemical study, conducted on the different parts of T. patula (roots, leaves and flowers) are found thiophenes, steroidal and terpenoidal type of constituents. Their structures were characterized by different spectroscopic. Among the thiophenes triterpens and steroids are two thiophenes, one triterpene and one steroid first time isolated from the genes Tegetes methods.
Alzheimer's Disease (AD), a slowly progressive neuropsychiatric illness, principally characterize... more Alzheimer's Disease (AD), a slowly progressive neuropsychiatric illness, principally characterized by memory deficits, has become the fourth leading cause of death in developed nations. Since the patients with AD suffer from marked reduction of cholinergic neuronal function resulting in a deficiency in acetylcholine (ACh) concentration in the brain, and these reductions are associated with impairments in memory, cholinergic enhancement strategies have been at the forefront of efforts to palliate pharmacologically the cognitive symptoms. Therefore, treatment approaches have been focused on the acetylcholinesterase inhibitors (AChEI) which are the most promising drugs demonstrating efficacy in the treatment of AD. Since, recently, galanthamine, an alkaloid isolated from different Galanthus species (Amaryllidaceae), has been found to be a potent and reversible acetylcholinesterase inhibitor, this development has prompted us to investigate the anticholinesterase activity in other plant species of Amaryllidaceae growing in Turkey, namely Galanthus elwesii, G. ikariae, Narcissus tazetta subsp. tazetta, Leucojum aestivum and Pancratium maritimum by Ellman method in comparison with galanthamine as the standard drug. Bioactivity-directed fractionation and isolation studies carried out on G. ikariae and N. tazetta subsp. tazetta extracts afforded 8 Amaryllidaceae-type alkaloids in total. We found that the activity of both of the plant extracts was due to the synergistic interaction of the alkaloids isolated. a Values were expressed as mean ± SEM p>0.05:-, p<0.05: + , p<0.01: ++ , p<0.001: +++
Five new di‐ and triglycosides, irigenin 7‐[O‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranoside] (1), ... more Five new di‐ and triglycosides, irigenin 7‐[O‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranoside] (1), 6‐hydroxygenistein 4′‐[O‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranoside] (2), nigricin 4′‐[O‐β‐D‐glucopyanosyl‐(1→6)‐β‐D‐glucopyranoside] (3), nigricin 4′‐[O‐β‐D‐glucopyanosyl‐(1→2)‐O‐[α‐L‐rhamnopyranosyl‐(1→6)]‐β‐D‐glucopyranoside] (4), and 7‐{4′‐{[2″‐O‐(4′′′′‐acetyl‐2′′′′‐methoxyphenyl)‐β‐D‐glucopyranosyl]oxy}‐3′‐(β‐D‐glucopyranosyloxy)phenyl]‐9‐methoxy‐8H‐1,3‐dioxolo[4,5‐g]‐[1 benzopyran‐8‐one‐] (5), along with a known compound, nigricin 4′‐(β‐D‐glucopyranoside) (6), were isolated from the rhizomes of Iris germanica. The structures of these compounds were established by spectroscopic methods, including 2D NMR spectroscopic techniques.
Many of the Turkish medicinal plants have useful medicinal aspects and contain alkaloids of poten... more Many of the Turkish medicinal plants have useful medicinal aspects and contain alkaloids of potential medicinal uses. Continuing our researches carried out on various medicinal plants have resulted in the isolation and structure elucidation of new and known alkaloids. During the last ten years, the isolation and structure elucidation of several new alkaloids from Fumaria, Corydalis, Ruta, Haplophyllum, Galium, Leucojum, Buxus, Thermopsis, Senecio, Consolida and Veratrum species growing in Turkey have been completed.
The Corydalis alkaloids have been investigated by differential pulse polarography as part of our ... more The Corydalis alkaloids have been investigated by differential pulse polarography as part of our continuing study of alkaloids. In this study, the alkaloidal content of Corydalis solida (L.) subsp. solida was determined. The results were compared by their structure and reduction mechanism. Quantitative analysis illustrates that Corydalis alkaloids can be determined down to sub‐ppm level using differential pulse polarography in Britton‐Robinson buffer pH 10. The amount of the various alkaloids in Corydalis solida (L.) subsp. solida have been shown. It was concluded that the reduction process at the dropping mercury electrode was catalytic in nature.
The ethanolic extracts of two shallow water sponge species collected from the Aegean Sea afforded... more The ethanolic extracts of two shallow water sponge species collected from the Aegean Sea afforded thirteen terpenoids in total, two of which were determined to be new. The structure elucidation of the terpenoids was carried out by spectroscopic techniques and comparison with related authentic compounds. The terpenoids have also been assayed for antibacterial activity. This is the first report about the metabolites isolated from the marine sponges of the Aegean Sea in Turkey.
The extract from the bulbs of Pancratium maritimum L. afforded 12 alkaloids belonging to the skel... more The extract from the bulbs of Pancratium maritimum L. afforded 12 alkaloids belonging to the skeletally six different groups of the Amaryllidaceae alkaloids. In this paper, the isolation and identification of (-)-N-demethyl-galanthamine (1), (+)-tazettine (2) and (-)-2-O-demethylmontanine (3) are described. Their structures have been determined by using extensive spectroscopic techniques. This is the first report describing the occurrence of 1 and 3 in this plant.
AbstractFrom plants of the species Fumaria judaica, growing in Turkey, a mixture of alkaloids (0.... more AbstractFrom plants of the species Fumaria judaica, growing in Turkey, a mixture of alkaloids (0.74%) was isolated. It contained as major alkaloids protopine (0.18%) and d-adlumidine (0.17%), together with β-allocryptopine (0.11%), 1-stylopine (0.11%), fumaritine (0.07%), coptisine (0.04%) and 1-scoulerine (0.03%).
The title compounds Tazettine (C18H21NO5) and Corydaldine (3,4‐dihydro‐6,7‐dimethoxy‐1(2H)‐isoqui... more The title compounds Tazettine (C18H21NO5) and Corydaldine (3,4‐dihydro‐6,7‐dimethoxy‐1(2H)‐isoquinolinone, C11H13NO3) have been isolated from the bulbs of Pancratium maritimum L. (Amaryllidaceae) and Corydalis solida subspecies brachyloba, respectively. The X‐ray structures were solvcd for Tazettine (I) and Corydaldine (II) (λ MoKα, R = 0.0499 and 0.0418, respectively). Crystals of (I) are orthorhombic, a = 7.115(1), b =13.377(1), c = 16.878(1) Å, Z = 4, Dcale = 1.370 g. cm−3, space group P212121. Crystals of (II) are monoclinic, a =10.641(1), b = 6.636(1), c = 14.938(1) Å, β = 90.31(1)°, Z = 4, Dcalc = 1.305 g. cm−3, space group P21/a.
Isoflavones have been extensively investigated for their potential health effects in areas includ... more Isoflavones have been extensively investigated for their potential health effects in areas including cardiovascular disease, cancer, osteoporosis, menopausal symptoms and cognitive function (Messina et al., 1994; Anderson and Garner, 1997). Daidzein and genistein, which are ...
AbstractThe total alkaloid content of Fumaria gaillardotii growing in Turkey has been investigate... more AbstractThe total alkaloid content of Fumaria gaillardotii growing in Turkey has been investigated. The structures of these alkaloids isolated from this plant have been elucidated: protopine, fumaritine, fumaricine, 1-stylopine, dl-bicuculline and N-methylhydrastine.
Phytochemical studies on an EtOH-soluble extract of the roots of Buxus sempervirens of Turkish or... more Phytochemical studies on an EtOH-soluble extract of the roots of Buxus sempervirens of Turkish origin have resulted in the isolation of three new steroidal alkaloids, (+)-semperviraminol (1), (+)-buxamine F (2), and (+)-17-oxocycloprotobuxine (3), along with two known steroidal alkaloids, (+)-buxoxybenzamine (4) and (+)-buxapapillinine (5). The structures of 1-3 were elucidated with the aid of spectroscopic studies. Compounds 4 and 5 exhibited phytotoxic activity against Lemna minor.
Tagetes patula (Asteraceae) is a medicinal plant which is indigenous to Tropical America but cult... more Tagetes patula (Asteraceae) is a medicinal plant which is indigenous to Tropical America but cultivated in Pakistan. During the chemical study, conducted on the different parts of T. patula (roots, leaves and flowers) are found thiophenes, steroidal and terpenoidal type of constituents. Their structures were characterized by different spectroscopic. Among the thiophenes triterpens and steroids are two thiophenes, one triterpene and one steroid first time isolated from the genes Tegetes methods.
Alzheimer's Disease (AD), a slowly progressive neuropsychiatric illness, principally characterize... more Alzheimer's Disease (AD), a slowly progressive neuropsychiatric illness, principally characterized by memory deficits, has become the fourth leading cause of death in developed nations. Since the patients with AD suffer from marked reduction of cholinergic neuronal function resulting in a deficiency in acetylcholine (ACh) concentration in the brain, and these reductions are associated with impairments in memory, cholinergic enhancement strategies have been at the forefront of efforts to palliate pharmacologically the cognitive symptoms. Therefore, treatment approaches have been focused on the acetylcholinesterase inhibitors (AChEI) which are the most promising drugs demonstrating efficacy in the treatment of AD. Since, recently, galanthamine, an alkaloid isolated from different Galanthus species (Amaryllidaceae), has been found to be a potent and reversible acetylcholinesterase inhibitor, this development has prompted us to investigate the anticholinesterase activity in other plant species of Amaryllidaceae growing in Turkey, namely Galanthus elwesii, G. ikariae, Narcissus tazetta subsp. tazetta, Leucojum aestivum and Pancratium maritimum by Ellman method in comparison with galanthamine as the standard drug. Bioactivity-directed fractionation and isolation studies carried out on G. ikariae and N. tazetta subsp. tazetta extracts afforded 8 Amaryllidaceae-type alkaloids in total. We found that the activity of both of the plant extracts was due to the synergistic interaction of the alkaloids isolated. a Values were expressed as mean ± SEM p>0.05:-, p<0.05: + , p<0.01: ++ , p<0.001: +++
Five new di‐ and triglycosides, irigenin 7‐[O‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranoside] (1), ... more Five new di‐ and triglycosides, irigenin 7‐[O‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranoside] (1), 6‐hydroxygenistein 4′‐[O‐β‐D‐glucopyranosyl‐(1→6)‐β‐D‐glucopyranoside] (2), nigricin 4′‐[O‐β‐D‐glucopyanosyl‐(1→6)‐β‐D‐glucopyranoside] (3), nigricin 4′‐[O‐β‐D‐glucopyanosyl‐(1→2)‐O‐[α‐L‐rhamnopyranosyl‐(1→6)]‐β‐D‐glucopyranoside] (4), and 7‐{4′‐{[2″‐O‐(4′′′′‐acetyl‐2′′′′‐methoxyphenyl)‐β‐D‐glucopyranosyl]oxy}‐3′‐(β‐D‐glucopyranosyloxy)phenyl]‐9‐methoxy‐8H‐1,3‐dioxolo[4,5‐g]‐[1 benzopyran‐8‐one‐] (5), along with a known compound, nigricin 4′‐(β‐D‐glucopyranoside) (6), were isolated from the rhizomes of Iris germanica. The structures of these compounds were established by spectroscopic methods, including 2D NMR spectroscopic techniques.
Many of the Turkish medicinal plants have useful medicinal aspects and contain alkaloids of poten... more Many of the Turkish medicinal plants have useful medicinal aspects and contain alkaloids of potential medicinal uses. Continuing our researches carried out on various medicinal plants have resulted in the isolation and structure elucidation of new and known alkaloids. During the last ten years, the isolation and structure elucidation of several new alkaloids from Fumaria, Corydalis, Ruta, Haplophyllum, Galium, Leucojum, Buxus, Thermopsis, Senecio, Consolida and Veratrum species growing in Turkey have been completed.
The Corydalis alkaloids have been investigated by differential pulse polarography as part of our ... more The Corydalis alkaloids have been investigated by differential pulse polarography as part of our continuing study of alkaloids. In this study, the alkaloidal content of Corydalis solida (L.) subsp. solida was determined. The results were compared by their structure and reduction mechanism. Quantitative analysis illustrates that Corydalis alkaloids can be determined down to sub‐ppm level using differential pulse polarography in Britton‐Robinson buffer pH 10. The amount of the various alkaloids in Corydalis solida (L.) subsp. solida have been shown. It was concluded that the reduction process at the dropping mercury electrode was catalytic in nature.
The ethanolic extracts of two shallow water sponge species collected from the Aegean Sea afforded... more The ethanolic extracts of two shallow water sponge species collected from the Aegean Sea afforded thirteen terpenoids in total, two of which were determined to be new. The structure elucidation of the terpenoids was carried out by spectroscopic techniques and comparison with related authentic compounds. The terpenoids have also been assayed for antibacterial activity. This is the first report about the metabolites isolated from the marine sponges of the Aegean Sea in Turkey.
The extract from the bulbs of Pancratium maritimum L. afforded 12 alkaloids belonging to the skel... more The extract from the bulbs of Pancratium maritimum L. afforded 12 alkaloids belonging to the skeletally six different groups of the Amaryllidaceae alkaloids. In this paper, the isolation and identification of (-)-N-demethyl-galanthamine (1), (+)-tazettine (2) and (-)-2-O-demethylmontanine (3) are described. Their structures have been determined by using extensive spectroscopic techniques. This is the first report describing the occurrence of 1 and 3 in this plant.
AbstractFrom plants of the species Fumaria judaica, growing in Turkey, a mixture of alkaloids (0.... more AbstractFrom plants of the species Fumaria judaica, growing in Turkey, a mixture of alkaloids (0.74%) was isolated. It contained as major alkaloids protopine (0.18%) and d-adlumidine (0.17%), together with β-allocryptopine (0.11%), 1-stylopine (0.11%), fumaritine (0.07%), coptisine (0.04%) and 1-scoulerine (0.03%).
The title compounds Tazettine (C18H21NO5) and Corydaldine (3,4‐dihydro‐6,7‐dimethoxy‐1(2H)‐isoqui... more The title compounds Tazettine (C18H21NO5) and Corydaldine (3,4‐dihydro‐6,7‐dimethoxy‐1(2H)‐isoquinolinone, C11H13NO3) have been isolated from the bulbs of Pancratium maritimum L. (Amaryllidaceae) and Corydalis solida subspecies brachyloba, respectively. The X‐ray structures were solvcd for Tazettine (I) and Corydaldine (II) (λ MoKα, R = 0.0499 and 0.0418, respectively). Crystals of (I) are orthorhombic, a = 7.115(1), b =13.377(1), c = 16.878(1) Å, Z = 4, Dcale = 1.370 g. cm−3, space group P212121. Crystals of (II) are monoclinic, a =10.641(1), b = 6.636(1), c = 14.938(1) Å, β = 90.31(1)°, Z = 4, Dcalc = 1.305 g. cm−3, space group P21/a.
Isoflavones have been extensively investigated for their potential health effects in areas includ... more Isoflavones have been extensively investigated for their potential health effects in areas including cardiovascular disease, cancer, osteoporosis, menopausal symptoms and cognitive function (Messina et al., 1994; Anderson and Garner, 1997). Daidzein and genistein, which are ...
AbstractThe total alkaloid content of Fumaria gaillardotii growing in Turkey has been investigate... more AbstractThe total alkaloid content of Fumaria gaillardotii growing in Turkey has been investigated. The structures of these alkaloids isolated from this plant have been elucidated: protopine, fumaritine, fumaricine, 1-stylopine, dl-bicuculline and N-methylhydrastine.
Phytochemical studies on an EtOH-soluble extract of the roots of Buxus sempervirens of Turkish or... more Phytochemical studies on an EtOH-soluble extract of the roots of Buxus sempervirens of Turkish origin have resulted in the isolation of three new steroidal alkaloids, (+)-semperviraminol (1), (+)-buxamine F (2), and (+)-17-oxocycloprotobuxine (3), along with two known steroidal alkaloids, (+)-buxoxybenzamine (4) and (+)-buxapapillinine (5). The structures of 1-3 were elucidated with the aid of spectroscopic studies. Compounds 4 and 5 exhibited phytotoxic activity against Lemna minor.
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