Nanotechnology has emerged as an inspiring tool for the effective delivery of drugs to help treat... more Nanotechnology has emerged as an inspiring tool for the effective delivery of drugs to help treat Coronary heart disease (CHD) which represents the most prevalent reason for mortality and morbidity globally. The current study focuses on the assessment of the cardioprotective prospective ofanovel combination nanoformulation of sericin and carvedilol. Sericin is a silk protein obtained from Bombyx mori cocoon and carvedilol is a synthetic nonselective β-blocker. In this present study, preparation of chitosan nanoparticles was performed via ionic gelation method and were evaluated for cardioprotective activity in doxorubicin (Dox)-induced cardiotoxicity. Serum biochemical markers of myocardial damage play a substantial role in the analysis of cardiovascular ailments and their increased levels have been observed to be significantly decreased in treatment groups. Treatment groups showed a decline in the positivity frequency of the Troponin T test as well. The NTG (Nanoparticle Treated Gr...
: Ursolic acid (UA) has been utilized to improve memory-related cognitive processes and intellect... more : Ursolic acid (UA) has been utilized to improve memory-related cognitive processes and intellectual functions. This study aims to examine the ethnobotanical uses, phytochemical composition, toxicity, and central nervous system activities of UA. It promotes learning and memory and has biological effects against Alzheimer's disease, Parkinson's disease, and cognitive impairment, according to pharmacological investigations. UA did not cause any death, abnormal body weight, or pathological diseases at any of the test doses. Furthermore, no behavioral, neurotoxin, coagulation, haematological, or clinical chemistry changes were seen as a result of UA treatment. UA is also used as a cosmeceutical product to improve skin functions. This article examines all knowledge that has become available at this time for revealing the chemistry of the current has been extensively investigated based on the data, resulting in UA derivatives with improved potency, bioavailability, and stability being used to treat a number of non-communicable diseases. The pharmacological activity of UA has been exploited to improve learning and memory and treat depression, emotional stress, fatigue, anxiety, insomnia, Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. The effects of UA on the central nervous system detailed in this review. The majority of UA studies have been preclinical evaluations of cellular mechanisms in the central nervous system, and more translational clinical research is needed to assess the drug's safety and efficacy, as well as its favorable, biodistribution, which could be targeted using different pathways and administration routes. Several in vitro and in vivo studies have investigated the pharmacological properties of UA reporting neuroprotective effects and improvements in cognitive function. These effects are attributed to its antioxidant, antiapoptotic, and anti-inflammatory actions.
World journal of pharmaceutical sciences, Feb 4, 2015
Essential medicines lists form the basis to improve the quality and cost effectiveness of health ... more Essential medicines lists form the basis to improve the quality and cost effectiveness of health care delivery when taken together with proper procurement policies and good prescribing practices. The Ministry of Health, Government of India revised the National List of Essential Medicines India (NLEMI 2011) in June 2011, eight years after the last revision. The NLEMI 2011 contains 348 medicines and was prepared over one and a half years by 87 experts. It is commendable that there are various positive aspects to the list such as detailed description of the revision process, inclusion of many experts from various fields in the review committee, well written description of the essential medicines concept and others; however a critical review of the list reveals areas of major and minor concerns. So there is a need of thorough comparison and critical review of the NLEM 2011 with WHO Essential drug list, 2013 and its compliance with the National Health Programs as well as the National Formulary of India 2010. Key words: Essential medicines, National list of essential medicines (NLEM), Ministry of Health and Family Welfare (MOHFW), World Health Organisation (WHO) Essential drug list.
Cardiometabolic disorders (CMD) is a constellation of metabolic predisposing factors for atherosc... more Cardiometabolic disorders (CMD) is a constellation of metabolic predisposing factors for atherosclerosis such as insulin resistance (IR) or diabetes mellitus (DM), systemic hypertension, central obesity, and dyslipidemia. Cardiometabolic diseases (CMDs) continue to be the leading cause of mortality in both developed and developing nations, accounting for over 32% of all fatalities globally each year. Furthermore, dyslipidemia, angina, arrhythmia, heart failure, myocardial infarction (MI), and diabetes mellitus are the major causes of death, accounting for an estimated 19 million deaths in 2012. CVDs will kill more than 23 million individuals each year by 2030. Nonetheless, new drug development (NDD) in CMDs has been increasingly difficult in recent decades due to increased costs and a lower success rate. Drug repositioning in CMDs looks promising in this scenario for launching current medicines for new therapeutic indications. Repositioning is an ancient method that dates back to th...
Diabetes mellitus is a metabolic disorder that is prima facie a cause for numerous macro and micr... more Diabetes mellitus is a metabolic disorder that is prima facie a cause for numerous macro and micro vascular complications. A common macroscopic complication associated with diabetes is cardiomyopathy. Cardiomyopathy refers to diseases of the heart muscle, where the heart muscle becomes enlarged, thick, or rigid. As cardiomyopathy worsens, the heart becomes weaker and is unable to conduct the right amount of blood through the body and maintain a normal electrical rhythm. This can lead to heart failure or arrhythmias. Chronic diabetes is one of the instigating factors behind the etiology of this cardiac complication. Type-II diabetes is associated with impaired glucose metabolism that increases the dependence of a diabetic heart on fatty acid oxidation to meet its functional demands, resulting in mitochondrial uncoupling, glucotoxicity, lipotoxicity and initially subclinical cardiac dysfunction that finally gives way to heart failure. The increasing diabetic population with cardiac di...
Ovarian cancer is characterized by the establishment of tolerance, the recurrence of disease, as ... more Ovarian cancer is characterized by the establishment of tolerance, the recurrence of disease, as well as a poor prognosis. Gene signatures in ovarian cancer cells enable cancer medicine research, therapy, prevention, & management problematic. Notwithstanding advances in tumor puncture surgery, novel combinations regimens, and abdominal radiation, which can provide outstanding reaction times, the bulk of gynecological tumor patients suffer from side effects & relapse. As a consequence, more therapy alternatives for individuals with ovarian cancer must always be studied to minimize side effects and improve progression-free and total response rates. The development of cancer medications is presently undergoing a renaissance in the quest for descriptive and prognostic ovarian cancer biomarkers. Nevertheless, abnormalities in the BRCA2 or BRCA1 genes, a variety of hereditary predispositions, unexplained onset and progression, molecular tumor diversity, and illness staging can all comprom...
It is well recognized that cyclic adenosine monophosphate (cAMP) signaling within neurons plays a... more It is well recognized that cyclic adenosine monophosphate (cAMP) signaling within neurons plays a key role in the foundation of long-term memories. Memory storage is the process that demands the movement of signals, neural plasticity, and the molecules which can transfer the signals from the sensory neuron to the dorsal root ganglion (DRG) neurons and later into the temporal region of the brain. The discovery of cAMP in 1958 as the second messenger also had a role in memory formation and other neural aspects. Further, in 1998 the scientists found that cAMP does not just activate protein kinase A (PKA) but also exchange protein directly activated by cAMP (Epac) which has an active role to play in hyperalgesia, memory, and signaling. The cAMP has three targets, hyperpolarization-activated cyclic nucleotide modulated (HCN) channels, protein kinase A (PKA), and exchange protein activated by cAMP (Epac). Different research has exposed that both PKA and HCN channels are significant for lo...
Objective: The objective of the study is to prepare and evaluate the safety assessment of novel c... more Objective: The objective of the study is to prepare and evaluate the safety assessment of novel combinatorial Nanoparticle formulation. Methods: Chitosan nanoparticles were prepared by the ionic gelation method with slight modification. Drug-drug interaction was evaluated by Fourier Transform Infra-Red Spectroscopy. Size, Polydispersity Index, Zeta potential, Transmission Electron Microscopy Characterizations were performed as per standard procedures. Acute and subacute toxicity assessments were done by the standard protocol of OECD guideline number 425 and 407, respectively. Results: Size and zeta-potential were found to be 186.7 nm and-12.0mV, respectively. TEM analysis showed uniform, smooth, and spherical-sized particles. FTIR analysis of carvedilol, sericin, and physical mixture showed no interaction between them. The safety evaluation of prepared nanoparticle which was found to be safe at a dose of up to 1000 mg/kg body weight in single-dose acute toxicity and multiple-dose su...
Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formulation compris... more Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formulation comprising constituents of herbal, animal, and mineral origin, holds salubrious cardioprotective potential and has been used for cardiac ailments in the Unani system for ages. KAHAW is a 'sugar-based' preparation, which hinders its 'claim to fame' amongst cardiac patients with diabetes. Hence, it is fascinating to develop a novel nanoformulation of the traditional one and screen its efficacy experimentally. To revolutionize this historic gem of a formulation and enhance its therapeutic efficacy, a novel nanoformulation of KAHAW was developed, and its cardioprotective potential screened against isoprenaline (ISO) induced cardiotoxicity in rodents. The results were analyzed with the traditional formulations and two clinically used drugs, Ramipril and Carvedilol. Various parameters viz; Physical, Enzymatic, Non-enzymatic, and cardiac-specific biomarkers like α/β-MHC expression (Wes...
Background: Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formula... more Background: Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formulation comprising constituents of herbal, animal, and mineral origin, holds salubrious cardioprotective potential and has been used for cardiac ailments in the Unani system for ages. KAHAW is a ‘sugar-based’ preparation, which hinders its ‘claim to fame’ amongst cardiac patients with diabetes. Hence, it is fascinating to develop a novel nanoformulation of the traditional one and screen its efficacy experimentally on the male Wistar rats (4-week-old) (150-180gm). The objective was to revolutionize this historic gem of a formulation and enhance its therapeutic efficacy, a novel nanoformulation of KAHAW was developed, and its cardioprotective potential screened against isoprenaline (ISO) induced cardiotoxicity in rodents. The results were analyzed with the traditional formulations and two clinically used drugs, Ramipril and Carvedilol. Methods: Various parameters viz; Physical, Enzymatic, Non...
Experimental and Clinical Endocrinology & Diabetes, 2022
Diabetic foot ulcers (DFUs) are the most common complications associated with diabetes mellitus. ... more Diabetic foot ulcers (DFUs) are the most common complications associated with diabetes mellitus. DFUs are displayed as open sores or wounds located on the bottom of the foot as a secondary complication of diabetes mellitus (DM). DFUs are associated with significant morbidity and mortality and can subsequently lead to hospitalization and lower limb amputation if not recognized and treated on time. An immense challenge to conventional treatments is caused by the chronic nature of diabetic foot syndrome and it has led to the emergence of nanotechnology-based therapeutics. The greatest advantages of these nanotherapeutics are their unique biological, chemical, and physical properties. The present review highlights the augmentation of bacterial infections relating to delayed healing of DFUs and the potential of nanotherapeutics such as polymeric nanoparticles, metallic nanoparticles, siRNA-based nanoparticles, lipid nanoparticles, and nanofibers in accelerating wound healing in diabetic ...
Annals of Phytomedicine: An International Journal, 2021
Curcumin, quercetin and rutin are pharmaceutical bioactive compounds but their usages are restric... more Curcumin, quercetin and rutin are pharmaceutical bioactive compounds but their usages are restricted because of low aqueous solubility and wettability which leads to poor dissolution, hence shows low bioavailability. The centre of consideration for this study is to provide solubility enhancement, improved bioavailability and provide a better patient compliance. To improve the hydrophilic and drug delivery characteristics, developed a beta-cyclodextrin and polyvinyl pyrrolidone K30 mediated fixed dose combination drug delivery system via solid dispersion technique. Inclusion complex was prepared as a fixed dose combination of these three bioactive phytoconstituent, obtained from natural sources with different polymers. The formations of inclusion complexes were characterized by Fourier transform infrared, drug content and drug dissolution. Saturation solubility studies also indicated that inclusion complex showed markable increased solubility compared toothers. Physical analysis of solid dispersion, when compared to its apparent compounds by FTIR allows for a change in solid state from the pure crystalline phase to the high-amorphous phase. The drug solubility increased in proportion to the increase in the concentration of polymer. The inclusion complex of PHC--CD prepared by solvent evaporation method demonstrated higher drug dissolution rates in comparison to solid dispersion prepared by solvent change precipitation method.
Objective: Oxidative stress, proteasomal impairment, mitochondrial dysfunction, and accumulation ... more Objective: Oxidative stress, proteasomal impairment, mitochondrial dysfunction, and accumulation of abnormal protein aggregates have shovelled a major section of the senior population towards neurodegenerative disorders. Although age, genetic and environmental factors are thought to play a significant role, drug abuse is considered to be a potent trigger in Parkinsonism among the young generation. The present study is a critical examination of herbal resources for attenuation of neurodegeneration. Materials and Methods: The following electronic databases have been used to search for literature: MEDLINE, Scopus, PubMed, and EMBASE Results : Paying heed to the prevalence of neurodegenerative disorders such as Alzheimer’s and Parkinson’s, the current review encompasses the pathogenesis of neurodegeneration at the cellular level and possible prospects to overcome the challenge sailing through the ocean of herbal boon. The United States’s Alzheimer’s Association states that deaths attrib...
Nanotechnology has emerged as an inspiring tool for the effective delivery of drugs to help treat... more Nanotechnology has emerged as an inspiring tool for the effective delivery of drugs to help treat Coronary heart disease (CHD) which represents the most prevalent reason for mortality and morbidity globally. The current study focuses on the assessment of the cardioprotective prospective ofanovel combination nanoformulation of sericin and carvedilol. Sericin is a silk protein obtained from Bombyx mori cocoon and carvedilol is a synthetic nonselective β-blocker. In this present study, preparation of chitosan nanoparticles was performed via ionic gelation method and were evaluated for cardioprotective activity in doxorubicin (Dox)-induced cardiotoxicity. Serum biochemical markers of myocardial damage play a substantial role in the analysis of cardiovascular ailments and their increased levels have been observed to be significantly decreased in treatment groups. Treatment groups showed a decline in the positivity frequency of the Troponin T test as well. The NTG (Nanoparticle Treated Gr...
: Ursolic acid (UA) has been utilized to improve memory-related cognitive processes and intellect... more : Ursolic acid (UA) has been utilized to improve memory-related cognitive processes and intellectual functions. This study aims to examine the ethnobotanical uses, phytochemical composition, toxicity, and central nervous system activities of UA. It promotes learning and memory and has biological effects against Alzheimer's disease, Parkinson's disease, and cognitive impairment, according to pharmacological investigations. UA did not cause any death, abnormal body weight, or pathological diseases at any of the test doses. Furthermore, no behavioral, neurotoxin, coagulation, haematological, or clinical chemistry changes were seen as a result of UA treatment. UA is also used as a cosmeceutical product to improve skin functions. This article examines all knowledge that has become available at this time for revealing the chemistry of the current has been extensively investigated based on the data, resulting in UA derivatives with improved potency, bioavailability, and stability being used to treat a number of non-communicable diseases. The pharmacological activity of UA has been exploited to improve learning and memory and treat depression, emotional stress, fatigue, anxiety, insomnia, Alzheimer’s disease, Parkinson’s disease, epilepsy, and schizophrenia. The effects of UA on the central nervous system detailed in this review. The majority of UA studies have been preclinical evaluations of cellular mechanisms in the central nervous system, and more translational clinical research is needed to assess the drug's safety and efficacy, as well as its favorable, biodistribution, which could be targeted using different pathways and administration routes. Several in vitro and in vivo studies have investigated the pharmacological properties of UA reporting neuroprotective effects and improvements in cognitive function. These effects are attributed to its antioxidant, antiapoptotic, and anti-inflammatory actions.
World journal of pharmaceutical sciences, Feb 4, 2015
Essential medicines lists form the basis to improve the quality and cost effectiveness of health ... more Essential medicines lists form the basis to improve the quality and cost effectiveness of health care delivery when taken together with proper procurement policies and good prescribing practices. The Ministry of Health, Government of India revised the National List of Essential Medicines India (NLEMI 2011) in June 2011, eight years after the last revision. The NLEMI 2011 contains 348 medicines and was prepared over one and a half years by 87 experts. It is commendable that there are various positive aspects to the list such as detailed description of the revision process, inclusion of many experts from various fields in the review committee, well written description of the essential medicines concept and others; however a critical review of the list reveals areas of major and minor concerns. So there is a need of thorough comparison and critical review of the NLEM 2011 with WHO Essential drug list, 2013 and its compliance with the National Health Programs as well as the National Formulary of India 2010. Key words: Essential medicines, National list of essential medicines (NLEM), Ministry of Health and Family Welfare (MOHFW), World Health Organisation (WHO) Essential drug list.
Cardiometabolic disorders (CMD) is a constellation of metabolic predisposing factors for atherosc... more Cardiometabolic disorders (CMD) is a constellation of metabolic predisposing factors for atherosclerosis such as insulin resistance (IR) or diabetes mellitus (DM), systemic hypertension, central obesity, and dyslipidemia. Cardiometabolic diseases (CMDs) continue to be the leading cause of mortality in both developed and developing nations, accounting for over 32% of all fatalities globally each year. Furthermore, dyslipidemia, angina, arrhythmia, heart failure, myocardial infarction (MI), and diabetes mellitus are the major causes of death, accounting for an estimated 19 million deaths in 2012. CVDs will kill more than 23 million individuals each year by 2030. Nonetheless, new drug development (NDD) in CMDs has been increasingly difficult in recent decades due to increased costs and a lower success rate. Drug repositioning in CMDs looks promising in this scenario for launching current medicines for new therapeutic indications. Repositioning is an ancient method that dates back to th...
Diabetes mellitus is a metabolic disorder that is prima facie a cause for numerous macro and micr... more Diabetes mellitus is a metabolic disorder that is prima facie a cause for numerous macro and micro vascular complications. A common macroscopic complication associated with diabetes is cardiomyopathy. Cardiomyopathy refers to diseases of the heart muscle, where the heart muscle becomes enlarged, thick, or rigid. As cardiomyopathy worsens, the heart becomes weaker and is unable to conduct the right amount of blood through the body and maintain a normal electrical rhythm. This can lead to heart failure or arrhythmias. Chronic diabetes is one of the instigating factors behind the etiology of this cardiac complication. Type-II diabetes is associated with impaired glucose metabolism that increases the dependence of a diabetic heart on fatty acid oxidation to meet its functional demands, resulting in mitochondrial uncoupling, glucotoxicity, lipotoxicity and initially subclinical cardiac dysfunction that finally gives way to heart failure. The increasing diabetic population with cardiac di...
Ovarian cancer is characterized by the establishment of tolerance, the recurrence of disease, as ... more Ovarian cancer is characterized by the establishment of tolerance, the recurrence of disease, as well as a poor prognosis. Gene signatures in ovarian cancer cells enable cancer medicine research, therapy, prevention, & management problematic. Notwithstanding advances in tumor puncture surgery, novel combinations regimens, and abdominal radiation, which can provide outstanding reaction times, the bulk of gynecological tumor patients suffer from side effects & relapse. As a consequence, more therapy alternatives for individuals with ovarian cancer must always be studied to minimize side effects and improve progression-free and total response rates. The development of cancer medications is presently undergoing a renaissance in the quest for descriptive and prognostic ovarian cancer biomarkers. Nevertheless, abnormalities in the BRCA2 or BRCA1 genes, a variety of hereditary predispositions, unexplained onset and progression, molecular tumor diversity, and illness staging can all comprom...
It is well recognized that cyclic adenosine monophosphate (cAMP) signaling within neurons plays a... more It is well recognized that cyclic adenosine monophosphate (cAMP) signaling within neurons plays a key role in the foundation of long-term memories. Memory storage is the process that demands the movement of signals, neural plasticity, and the molecules which can transfer the signals from the sensory neuron to the dorsal root ganglion (DRG) neurons and later into the temporal region of the brain. The discovery of cAMP in 1958 as the second messenger also had a role in memory formation and other neural aspects. Further, in 1998 the scientists found that cAMP does not just activate protein kinase A (PKA) but also exchange protein directly activated by cAMP (Epac) which has an active role to play in hyperalgesia, memory, and signaling. The cAMP has three targets, hyperpolarization-activated cyclic nucleotide modulated (HCN) channels, protein kinase A (PKA), and exchange protein activated by cAMP (Epac). Different research has exposed that both PKA and HCN channels are significant for lo...
Objective: The objective of the study is to prepare and evaluate the safety assessment of novel c... more Objective: The objective of the study is to prepare and evaluate the safety assessment of novel combinatorial Nanoparticle formulation. Methods: Chitosan nanoparticles were prepared by the ionic gelation method with slight modification. Drug-drug interaction was evaluated by Fourier Transform Infra-Red Spectroscopy. Size, Polydispersity Index, Zeta potential, Transmission Electron Microscopy Characterizations were performed as per standard procedures. Acute and subacute toxicity assessments were done by the standard protocol of OECD guideline number 425 and 407, respectively. Results: Size and zeta-potential were found to be 186.7 nm and-12.0mV, respectively. TEM analysis showed uniform, smooth, and spherical-sized particles. FTIR analysis of carvedilol, sericin, and physical mixture showed no interaction between them. The safety evaluation of prepared nanoparticle which was found to be safe at a dose of up to 1000 mg/kg body weight in single-dose acute toxicity and multiple-dose su...
Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formulation compris... more Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formulation comprising constituents of herbal, animal, and mineral origin, holds salubrious cardioprotective potential and has been used for cardiac ailments in the Unani system for ages. KAHAW is a 'sugar-based' preparation, which hinders its 'claim to fame' amongst cardiac patients with diabetes. Hence, it is fascinating to develop a novel nanoformulation of the traditional one and screen its efficacy experimentally. To revolutionize this historic gem of a formulation and enhance its therapeutic efficacy, a novel nanoformulation of KAHAW was developed, and its cardioprotective potential screened against isoprenaline (ISO) induced cardiotoxicity in rodents. The results were analyzed with the traditional formulations and two clinically used drugs, Ramipril and Carvedilol. Various parameters viz; Physical, Enzymatic, Non-enzymatic, and cardiac-specific biomarkers like α/β-MHC expression (Wes...
Background: Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formula... more Background: Khamira Abresham Hakim Arshadwala (KAHAW), a distinguished, traditional Unani formulation comprising constituents of herbal, animal, and mineral origin, holds salubrious cardioprotective potential and has been used for cardiac ailments in the Unani system for ages. KAHAW is a ‘sugar-based’ preparation, which hinders its ‘claim to fame’ amongst cardiac patients with diabetes. Hence, it is fascinating to develop a novel nanoformulation of the traditional one and screen its efficacy experimentally on the male Wistar rats (4-week-old) (150-180gm). The objective was to revolutionize this historic gem of a formulation and enhance its therapeutic efficacy, a novel nanoformulation of KAHAW was developed, and its cardioprotective potential screened against isoprenaline (ISO) induced cardiotoxicity in rodents. The results were analyzed with the traditional formulations and two clinically used drugs, Ramipril and Carvedilol. Methods: Various parameters viz; Physical, Enzymatic, Non...
Experimental and Clinical Endocrinology & Diabetes, 2022
Diabetic foot ulcers (DFUs) are the most common complications associated with diabetes mellitus. ... more Diabetic foot ulcers (DFUs) are the most common complications associated with diabetes mellitus. DFUs are displayed as open sores or wounds located on the bottom of the foot as a secondary complication of diabetes mellitus (DM). DFUs are associated with significant morbidity and mortality and can subsequently lead to hospitalization and lower limb amputation if not recognized and treated on time. An immense challenge to conventional treatments is caused by the chronic nature of diabetic foot syndrome and it has led to the emergence of nanotechnology-based therapeutics. The greatest advantages of these nanotherapeutics are their unique biological, chemical, and physical properties. The present review highlights the augmentation of bacterial infections relating to delayed healing of DFUs and the potential of nanotherapeutics such as polymeric nanoparticles, metallic nanoparticles, siRNA-based nanoparticles, lipid nanoparticles, and nanofibers in accelerating wound healing in diabetic ...
Annals of Phytomedicine: An International Journal, 2021
Curcumin, quercetin and rutin are pharmaceutical bioactive compounds but their usages are restric... more Curcumin, quercetin and rutin are pharmaceutical bioactive compounds but their usages are restricted because of low aqueous solubility and wettability which leads to poor dissolution, hence shows low bioavailability. The centre of consideration for this study is to provide solubility enhancement, improved bioavailability and provide a better patient compliance. To improve the hydrophilic and drug delivery characteristics, developed a beta-cyclodextrin and polyvinyl pyrrolidone K30 mediated fixed dose combination drug delivery system via solid dispersion technique. Inclusion complex was prepared as a fixed dose combination of these three bioactive phytoconstituent, obtained from natural sources with different polymers. The formations of inclusion complexes were characterized by Fourier transform infrared, drug content and drug dissolution. Saturation solubility studies also indicated that inclusion complex showed markable increased solubility compared toothers. Physical analysis of solid dispersion, when compared to its apparent compounds by FTIR allows for a change in solid state from the pure crystalline phase to the high-amorphous phase. The drug solubility increased in proportion to the increase in the concentration of polymer. The inclusion complex of PHC--CD prepared by solvent evaporation method demonstrated higher drug dissolution rates in comparison to solid dispersion prepared by solvent change precipitation method.
Objective: Oxidative stress, proteasomal impairment, mitochondrial dysfunction, and accumulation ... more Objective: Oxidative stress, proteasomal impairment, mitochondrial dysfunction, and accumulation of abnormal protein aggregates have shovelled a major section of the senior population towards neurodegenerative disorders. Although age, genetic and environmental factors are thought to play a significant role, drug abuse is considered to be a potent trigger in Parkinsonism among the young generation. The present study is a critical examination of herbal resources for attenuation of neurodegeneration. Materials and Methods: The following electronic databases have been used to search for literature: MEDLINE, Scopus, PubMed, and EMBASE Results : Paying heed to the prevalence of neurodegenerative disorders such as Alzheimer’s and Parkinson’s, the current review encompasses the pathogenesis of neurodegeneration at the cellular level and possible prospects to overcome the challenge sailing through the ocean of herbal boon. The United States’s Alzheimer’s Association states that deaths attrib...
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