Papers by Sift Desk Journals
Sift Desk Journals, 2022
Objective: To investigate the correlation between clinico-pathological features and lymph node me... more Objective: To investigate the correlation between clinico-pathological features and lymph node metastasis of thyroid micropapillary carcinoma (PTMC).
Methods: the clinico-pathological data of 142 cases of thyroid micropapillary carcinoma were collected, the relationship between sex, age, tumor location, multi-focality and cervical lymph node metastasis was analyzed.
Results: There was a high rate of lymph node metastasis in male patients with PTMC. There was no significant correlation between age, multifocality and lymph node metastasis. Conclusion: The histological subtypes of PTMC have different clinicopathological characteristics and are important factors for cervical lymph node metastasis. Further evaluation of its histological classification is helpful for clinical treatment strategy.
Sift Desk Journals, 2022
The study investigated the use of Pb isotope signatures as an indicative of origin assessment of ... more The study investigated the use of Pb isotope signatures as an indicative of origin assessment of uranium bearing ore mineralisation from the uranium province in Namibia. The objective of the study was to determine signatures of Pb from uranium ore mineralisation, identify as to the Pb present is geogenic and/or antrogenic and provided an estimate of the age of the uranium ore mineralisation from measured Pb isotope.
A total of 24 samples of uranium ore were collected from three mines and the lead isotopic ratios and age estimation signatures of the uranium ore mineralisation determined. Inductively Coupled Plasma Mass Spectrometer was employed for sample analysis. 206Pb was abundant in the ore samples and was determined to be geogenic and not anthropogenic. The estimated age of the uranium ore mineralisation was in the range documented for the Namibian Damara Orogen. The studied showed that lead isotopic ratios can provide an estimate of the age of the uranium ore mineralisation and aid as a fool in nuclear forensics.
Key words: Lead isotopic ratios, uranium ore mineralization, nuclear forensics, geochronology
Sift Desk Journals, 2022
Background: Previous studies have demonstrated the superiority of sugammadex over neostigmine for... more Background: Previous studies have demonstrated the superiority of sugammadex over neostigmine for reversal of nondepolarizing neuromuscular blockade (NMB) reversal. However, its increased cost over neostigmine remains a barrier to use in many institutions.
Aims: The purposes of this study were to compare the outcomes of patients receiving neostigmine alone vs. patients receiving neostigmine and sugammadex and to identify the risk factors for patients requiring sugammadex as a rescue neuromuscular blockade reversal agent.
Methods: A retrospective observational study of general anesthesia cases using rocuronium or vecuronium for NMB at a single regional medical center from January 1, 2019 to March 30, 2021 was performed. Demographics, surgical details, and outcomes of patients receiving neostigmine only (N) were compared to those of patients receiving neostigmine followed by sugammadex (NS). A conditional logistic regression model was developed to identify predictors of patients requiring a rescue dose of sugammadex for NMB reversal.
Results: A total of 7104 patients were included (N=6684, NS=420). In comparison to patients in the N group, those in the NS group experienced shorter duration from last NMB administration to first reversal, longer PACU recovery times, longer length of stay, and higher rates of reintubation. After risk adjustment, patients receiving NS were more likely to be female, of non-white race, have increased BMIs, and a greater comorbidity burden than those requiring N only. In comparison to patients undergoing general surgery, those undergoing thoracic surgery are at increased risk for requiring NS. A model for predicting which patients would receive NS was generated with an AUC of 0.681 (95% CI: 0.654-0.708), sensitivity of 78% and specificity of 48%.
Conclusion: These findings may assist anesthesiologists in identifying which patients are likely to require sugammadex for rescue NMB reversal after use of neostigmine and are therefore suitable candidates for using sugammadex as a first-line therapy.
Key Words : Neuromuscular blockade reversal, sugammadex, neostigmine, residual neuromuscular blockade, predictive model
Core Tip: After risk adjustment, patients who were female, of non-white race, have increased BMIs, have a greater comorbidity burden, or undergo thoracic surgery are at increased risk for requiring sugammadex after neostigmine. A model for predicting which patients would receive neostigmine and sugammadex was generated with an AUC of 0.681 (95% CI: 0.654-0.708), sensitivity of 78% and specificity of 48%. These findings may assist anesthesiologists in identifying which patients are likely to require sugammadex for rescue NMB reversal after use of neostigmine and are therefore suitable candidates for using sugammadex as a first-line therapy.
The sustainability of the shrimp aquaculture depends largely on disease control and the health st... more The sustainability of the shrimp aquaculture depends largely on disease control and the health status of shrimp. Probiotics, which make shrimps healthier and more resistant to pathogens, are promising countermeasure for shrimp diseases. In this study, the effects of the marine purple non-sulfur photosynthetic bacterium (PNSB) Rhodovulum sulfidophilum on Marsupenaeus japonicus (kuruma shrimp) growth and survival were examined in 177 m aquaria (140 tons of water) for 70 days. The shrimp received feed containing 0.01 % fresh weight (10 colony forming unit/g) of R. sulfidophilum cells. The survival rate significantly improved (P < 0.001) (R. sulfidophilum-fed = 81.9 %; control = 71.5 %), the feed conversion rate improved (R. sulfidophilum-fed = 1.83; control = 2.11), and there was no difference in the shrimp average body weight. The approximate bacterial cell cost was $0.003 to $0.005 per 1 kg feed, indicating that the R. sulfidophilum approach is economically feasible and a promisin...
Insects could serve as an alternative amino acids source with less environmental impact and low p... more Insects could serve as an alternative amino acids source with less environmental impact and low production cost. In this study, phenylisothiocianate (PITC) pre–column derivatization and high-pressure liquid chromatographic (HPLC) method combined with solid phase extraction (SPE) was developed and used to quantify free amino acids present in American cockroach. Powdered cockroach sample were extracted in water at 90 C for 20 min, pre-purified on silica-based cationic exchange (SCX) cartridges, derivatized and analyzed for the free amino acid compositions. The free amino acids derivatives were separated on Agilent Zorbax Extend-C18 (4.6 x 250 mm, 5 μm) HPLC column at 33 ± 0.1 C with diode array detection (DAD) set at 254 nm. A total analysis time of 30 min was used to separate 15 amino acids including nine essential and six non-essential ones with gradient elution at a flow rate of 1.0 mL/min. The results showed linear calibration range from 50 to 150 pmol/uL for all the free amino ac...
SDRP Journal of Cellular and Molecular Physiology, 2020
In this study, the effects of black vinegar (BA) and niacinamide on lipopolysaccharide (LPS)-trea... more In this study, the effects of black vinegar (BA) and niacinamide on lipopolysaccharide (LPS)-treated human keratinocytes, HaCaT cells, were investigated. First of all, BA and niacinamide have no cytotoxicity in HaCaT cells even at high concentrations. LPS treatment triggers the phosphorylation of p38 mitogen-activated protein kinases (MAPK) and the expression of inflammatory enzymes, iNOS and COX-2. In contrast, BA and niacinamide weakened the expression of LPS-induced COX-2 and iNOS. Based on the results, we concluded that BA and niacinamide have effective anti-inflammatory properties in HaCaT cells. Therefore, BA and niacinamide may be used as new alternative treatments for inflammatory skin diseases. Keywords: Black vinegar, HaCaT cell, Inflammation, Keratinocytes, Liposaccharides, Niacinamide
SDRP Journal of Aquaculture, Fisheries & Fish Science, 2020
The present study reviewed the literature published in recent years on the topic "Recirculating A... more The present study reviewed the literature published in recent years on the topic "Recirculating Aquaculture Systems (RAS)", a technology that makes it possible to grow aquatic organisms more sustainably and environmentally friendly, reducing water consumption, environmental pollution and land use. Commercial and academic application of recirculating aquaculture systems has increased considerably in recent years. The RAS is considered a master key for the increase of sustainable aquaculture, with the possibility of flexibility in its productive structure, ability to control environmental variables and the possibility of production throughout the year. This review provides an overview of aquaculture, RAS, sustainability and research perspectives.
SDRP Journal of Food Science & Technology, 2020
Background: Salt stress, one of the most important abiotic stresses, severely reduces crop yields... more Background: Salt stress, one of the most important abiotic stresses, severely reduces crop yields. Identifying salt-tolerant rice germplasm resources at the germination stage, developing salt tolerance indicators, and cultivating salt-tolerant rice cultivars are crucial for improving rice production in saline soil. Results: We measured the germination parameters of 140 japonica rice cultivars on the 7 day after sowing (DAS) in 0 and 150 mmol L −1 NaCl. To accurately assess salt tolerance and identify reliable indicators of salt tolerance, we measured the shoot length (SL), root length (RL), root fresh weight (RFW), shoot fresh weight (SFW), total fresh weight (TFW) and salt tolerance (STI) index after 7 days of salt-stress treatment. The 140 rice cultivars were divided into four categories based on the mean MFVs: highly salt tolerant (HST: 19 cultivars), salt tolerant (ST: 74 cultivars), weakly salt tolerant (WST: 43 cultivars), and salt sensitive (SS: 4 cultivars). Based on the physiological indicators, we established a mathematical model to accurately evaluate salt tolerance in japonica rice cultivars. STI of TFW under 150 mmol L −1 NaCl treatment showed the highest correlation with salt tolerance during the germination stage. Conclusions: We determined the optimum NaCl concentration (150 mmol L −1) for evaluating salt tolerance in japonica rice at the germination stage. We identified 19 HST, 74 ST, 43 WST, and 4 SS japonica rice cultivars during the germination stage and proposed a mathematical model to evaluate salt tolerance. STI of TFW is a reliable, accurate indicator for evaluating salt tolerance in japonica rice. These findings should greatly facilitate the evaluation of japonica rice cultivars during seed germination and the breeding of salt-tolerant rice cultivars. Background Soil salinization is an important ecological problem that seriously affects crop growth and reduces agricultural production worldwide. More than 800 million hectares of land worldwide are affected by salt, accounting for more than 6% of the world's total land area (Munns 2005). In China, there are approximately 100 million hectares of saline land (Yuan et al. 2016). Recently, salinization is increasing rapidly due to the overuse of chemical fertilizers, poor irrigation practices, and industrial
SDRP Journal of Food Science & Technology, 2018
Polyphenol oxidase (PPO, EC 1.14.18.1) is the main enzyme responsible for enzymatic browning, a n... more Polyphenol oxidase (PPO, EC 1.14.18.1) is the main enzyme responsible for enzymatic browning, a natural process which produces deterioration of fruits and vegetables. One alternative to prevent this undesirable process is to inhibit the catalytic activity of PPO by encapsulating enzyme's substrates in cyclodextrins (CD). In this article the effect of a Thiol-CD on PPO from Red Delicious apple was studied, demonstrating that this compound is a powerful tool for controlling oxidative processes in food. Thiol-CD could encapsulate the polyphenols, natural substrates of the enzyme, by means of the cyclodextrin hydrophobic internal cavity. Simultaneously, through the thiol group, it could inactivate the PPO by reducing the copper ions from the active site of the enzyme. Moreover, thiol moieties could decrease the browning by reducing the quinones generated by oxidative processes. The isolation and purification of PPO from apple was performed in order to study those effects, different polyphenols, chlorogenic acid (CA) and 4-methylcatechol (4-MC), were assayed as enzymatic substrates. Both β-CD and Thiol-CD exhibited better enzyme inhibition value for CA than for 4-MC. Moreover, Thiol-CD showed an extraordinary performance compared with β-CD. When CA 10 mM was used, 5 mM β-CD gave 11 % PPO inhibition, meanwhile nearly 100 times less concentration of Thiol-CD (45 μM) gave 100 % of enzyme inhibition. KEYWORDS Antibrowning agents, enzymatic browning, oxidative processes in food.
SDRP Journal of Food Science & Technology, 2018
Pre-analytical sampling conditions play an important role for the correct determination of blood ... more Pre-analytical sampling conditions play an important role for the correct determination of blood concentrations of biomarkers and drugs in the clinical environment. In the context of daily clinical routine and clinical studies, oxidative stability in vitro should be carefully considered. Herein we report differences in vitamin C levels under commonly used handling and storage conditions and we propose a simple and efficient sampling protocol. Plasma and serum samples were analyzed by HPLC-UV and different handling-, timeand storage conditions were investigated in detail. Our findings show that protection from oxidation significantly prevented degradation under different storage conditions. The immediate separation of stabilized plasma from blood cells showed a protective effect on vitamin C stability. In addition, long-term storage of vitamin C was positively influenced by addition of protective agents, assuring stability up to six months. Oxidative degradation could affect not only vitamin C but also other small molecule metabolites and should therefore be intensively evaluated before implementation in daily clinical routine as well as in metabolomics studies.
SDRP Journal of Plant Science, 2020
Background: Pentacyclic triterpenes are plant secondary metabolites that have many applications f... more Background: Pentacyclic triterpenes are plant secondary metabolites that have many applications for health of the people. Methods: In this work, we determine by a HPLC-UV/Vis and HPLC-MS what pentacyclic triterpenes are found in stem and root of cv. Picual olive tree, a variety typically grown in the area of Jaén (Spain). Moreover, the concentration of these compounds along fruit ripening also has been determined in both organs. Results: Maslinic acid (MA), oleanolic acid (OA), erythrodiol (EO), and uvaol (UO) have been found in stem. OA is the compound that shown the highest concentration in this organ. MA, betulinic acid (BA), OA and ursolic acid have been found in root. In general, BA has the highest concentration in this organ. BA had not been detected in other olive tree organs. Conclusion: The evolution showed by the concentrations of these compounds during ripening suggests the existence of two different phases: the first related with the increment in weight of fruit and the second related with the ripening following. The evolution found in stem is different to the found in root and we believe that are related with the functions of these compounds in each organ.
SDRP Journal of Computational Chemistry & Molecular Modelling, 2020
Oxytocin (OT) is a neurohypophysial hormone, which acts both on the peripheral tissues and as a n... more Oxytocin (OT) is a neurohypophysial hormone, which acts both on the peripheral tissues and as a neurotransmitter in the brain. It plays an important role in the control of uterine contractions during labor, secretion of milk and regulates many social and behavioural functions. OT accomplishes its functions via interaction with specific oxytocin receptors (OTRs), which belong to the rhodopsin type (family A) group of G-protein coupled receptors (GPCRs). Increased oxytocin secretion associated with hormonal abnormalities in endocrine glands (thyroid, pituitary) during pregnancy may cause premature birth. Oxytocin receptor antagonists are widely employed for prevention in such cases. Design of these antagonists requires a proper model of the hormone-receptor interaction. However, the 3D structure of the OTR is not known. The aim of this investigation is to construct a three-dimensional model of the oxytocin receptor, to be used to define the binding sites between oxytocin and its receptor, as a prerequisite for further search for oxytocin antagonists. We employ homology modeling as an efficient technique to generate a family of oxytocin GPCRs structures. The best structure is investigated for its interactions with the hormone oxytocin through molecular dynamics (MD) simulations. The potential oxytocin-receptor binding sites are determined. The structural changes in the receptor induced by oxytocin binding are investigated.
SDRP Journal of Computational Chemistry & Molecular Modelling, 2020
Fifteen imidazolidine nitroxide radicals were synthesised, and their stabilities against ascorbat... more Fifteen imidazolidine nitroxide radicals were synthesised, and their stabilities against ascorbate were investigated. Among them, it was found that radicals bearing OH groups exhibited improved stabilities. In addition, density functional theory calculations, evaluation method of steric shielding effect around nitroxide radical reaction center based on molecular volume within a virtual ball, multiple regression analysis showed that the half-lives of these radicals were influenced both by steric effects and by the charge on the ring nitrogen atom.
SDRP Journal of Food Science & Technology, 2019
There are continuous research and industrial application for osmo-convective dehydration as a cho... more There are continuous research and industrial application for osmo-convective dehydration as a choice technology for the processing of dried fruit snacks and the development of new functional fruit snacks. Owning to the quality loss and a high energy investment associated with the convective dehydration of fresh fruits into dry snacks; osmotic dehydration prior to convective dehydration has become widely used for quality improvement, energy conservation and production of functional dried fruits snacks. In this review, we address the current knowledge in the use of osmo-convective dehydration to produce dried fruit snacks by providing information on the optimized process condition for producing such dried fruit snacks. Additionally, we present a summary of information on the effects of osmo-convective dehydration on the shelf life, nutritional quality, and microbial stability of dried fruit snacks. Finally, we provide information on the potential application of osmo-convective dehydration in developing functional fruits.
SDRP Journal of Food Science & Technology, 2019
In this study, the migration rule of plasticizer to pork and its influencing factor (temperature ... more In this study, the migration rule of plasticizer to pork and its influencing factor (temperature and fat content) were studied with DEHP and DEHA in polyvinyl chloride (PVC) fresh-keeping film as objects. Based on the migration experimental data, the predicted model of DEHP and DEHA was presented using established Weibull distribution probability model. Finally, the migration prediction values, and experimental values were compared under two different conditions (17.5% fat content at 40 °C and 37.5% fat content at 25 °C), and the results showed that there were no significant differences.
SDRP Journal of Earth Sciences & Environmental Studies, 2019
Fluopyram is one of the widely used fungicides and it is persistence in water and soil. In this s... more Fluopyram is one of the widely used fungicides and it is persistence in water and soil. In this study, the photocatalytic degradation of fluopyram by TiO 2 was investigated under simulated solar light irradiation. Six transformation products (TPs) were identified by means of high performance liquid chromatography coupled with tandem mass spectrometry (HPLC-MS/MS) and the quantum chemistry calculations (DFT and AIMD method). The formation of these TPs involved the hydroxyl-substitution of Cl atom, intramolecular cyclization, cleavage of amido bond, loss of trifluorotoluene, and attack of hydroxyl group on benzene ring. And then, a tentative pathway of the photocatalytic degradation was proposed. The toxicity of fluopyram and its TPs were predicted using in silico test. The results showed that potentially more toxic intermediates formed during photocatalytic degradation. These data suggested that more information about TPs of fluopyram and their toxicity should be obtained.
SDRP Journal of Food Science & Technology, 2018
Impact of fructose and fructooligosaccharides supplementation upon the fermentation of hydrolyzed... more Impact of fructose and fructooligosaccharides supplementation upon the fermentation of hydrolyzed okara and its impact upon bioactive components (2018)SDRP Journal of Food Science & Technology 3(5) RESEARCH HIGHLIGHTS 1. Okara hydrolysate showed to be as good matrix for probiotic bacteria growth 2. Okara (soybean pulp) was fermented using B. animalis ssp. lactis Bb-12, L. rhamnosus R11 or a combination of both. 3. Aglycones content in fermented okara can improve biological functionality of isoflavones 4. The fermented okara can be a potential food product.
SDRP Journal of Food Science & Technology, 2018
CITATION Mesías M, Evaluation of domestic frying habits and consumer's preferences in Spanish hou... more CITATION Mesías M, Evaluation of domestic frying habits and consumer's preferences in Spanish households(2018)SDRP Journal of Food Science & Technology 3(5) RESEARCH HIGHLIGHTS 1. Deep-frying habits and consumer's preferences in Spanish households were evaluated. 2. Fried food consumption in the Spanish population is close to other Western countries. 3. Fried potatoes were the most consumed fried food among the Spanish population. 4. The most common appliance for the frying process was the frying pan. 5. Olive oil was the oil mainly employed for the frying procedure.
SDRP Journal of Food Science & Technology, 2018
Presently, there is growing interest to use agricultural wastes as by-products for further exploi... more Presently, there is growing interest to use agricultural wastes as by-products for further exploitation as food additives or supplements. The waste product which is typically thrown into the environment has been revealed to exhibit certain nutritional and pharmacological properties. Some functional compounds have been reported to exert significant nutritional and pharmacological properties such as antioxidant, anticancer, antidiabetic, antimicrobial, etc. Based on recent literature, many reports or studies focused on the utilization and pharmacological effects of some selected agro-industrial by-products. This trend could provide the theoretical basis for further rational development and utilization of the waste for the therapeutic and health purposes.
Sift Desk Journals, 2022
A feeding trial was conducted to evaluate the effects of different sugar sources on growth perfor... more A feeding trial was conducted to evaluate the effects of different sugar sources on growth performance, serum biochemistry, immunity, insulin receptor 1 and tyrosine kinase activity of GIFT tilapia. Four hundred and eighty fish with specifications of 31.70±0.68 g were selected and placed in 16 aquariums. The experiment was divided into four treatment with four replicates of thirty fish per tank. After 50 days of feeding, the results were as follows: From the indexes of final average weight, weight gain rate and specific growth rate, the growth performance was sucrose, glucose, starch and dextrin group in turn, and the sucrose group performed best (P<0.05). The activcities of acid phosphotase, alkaline phosphotase, superoxide dismutase and lysozyme in sucrose group were significantly higher than that of the other three groups (P<0.05). The serum glucose level of sucrose group and glucose group is significantly higher than that of dextrin group and starch group (P < 0.05). In terms of liver glycogen level, the content of sucrose group was significantly higher than that of dextrin group and starch group (P < 0.05). In terms of muscle glycogen level, the content of sucrose group was the highest and that of starch group was the lowest. The tyrosine kinase activity of glucose group was the highest and significantly different from dextrin group (P< 0.05). The tyrosine kinase activity in muscle was always higher than that in liver (P < 0.05). The IR-1 mRNA in starch group and dextrin group was significantly higher than that in sucrose group. Different sugar source diets had a significant effect on the expression of IR-1 mRNA in the muscle of tilapia. In conclusion, compared with dextrin and starch, sucrose and glucose can be better utilized by GIFT tilapia and show good growth performance.
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Papers by Sift Desk Journals
Methods: the clinico-pathological data of 142 cases of thyroid micropapillary carcinoma were collected, the relationship between sex, age, tumor location, multi-focality and cervical lymph node metastasis was analyzed.
Results: There was a high rate of lymph node metastasis in male patients with PTMC. There was no significant correlation between age, multifocality and lymph node metastasis. Conclusion: The histological subtypes of PTMC have different clinicopathological characteristics and are important factors for cervical lymph node metastasis. Further evaluation of its histological classification is helpful for clinical treatment strategy.
A total of 24 samples of uranium ore were collected from three mines and the lead isotopic ratios and age estimation signatures of the uranium ore mineralisation determined. Inductively Coupled Plasma Mass Spectrometer was employed for sample analysis. 206Pb was abundant in the ore samples and was determined to be geogenic and not anthropogenic. The estimated age of the uranium ore mineralisation was in the range documented for the Namibian Damara Orogen. The studied showed that lead isotopic ratios can provide an estimate of the age of the uranium ore mineralisation and aid as a fool in nuclear forensics.
Key words: Lead isotopic ratios, uranium ore mineralization, nuclear forensics, geochronology
Aims: The purposes of this study were to compare the outcomes of patients receiving neostigmine alone vs. patients receiving neostigmine and sugammadex and to identify the risk factors for patients requiring sugammadex as a rescue neuromuscular blockade reversal agent.
Methods: A retrospective observational study of general anesthesia cases using rocuronium or vecuronium for NMB at a single regional medical center from January 1, 2019 to March 30, 2021 was performed. Demographics, surgical details, and outcomes of patients receiving neostigmine only (N) were compared to those of patients receiving neostigmine followed by sugammadex (NS). A conditional logistic regression model was developed to identify predictors of patients requiring a rescue dose of sugammadex for NMB reversal.
Results: A total of 7104 patients were included (N=6684, NS=420). In comparison to patients in the N group, those in the NS group experienced shorter duration from last NMB administration to first reversal, longer PACU recovery times, longer length of stay, and higher rates of reintubation. After risk adjustment, patients receiving NS were more likely to be female, of non-white race, have increased BMIs, and a greater comorbidity burden than those requiring N only. In comparison to patients undergoing general surgery, those undergoing thoracic surgery are at increased risk for requiring NS. A model for predicting which patients would receive NS was generated with an AUC of 0.681 (95% CI: 0.654-0.708), sensitivity of 78% and specificity of 48%.
Conclusion: These findings may assist anesthesiologists in identifying which patients are likely to require sugammadex for rescue NMB reversal after use of neostigmine and are therefore suitable candidates for using sugammadex as a first-line therapy.
Key Words : Neuromuscular blockade reversal, sugammadex, neostigmine, residual neuromuscular blockade, predictive model
Core Tip: After risk adjustment, patients who were female, of non-white race, have increased BMIs, have a greater comorbidity burden, or undergo thoracic surgery are at increased risk for requiring sugammadex after neostigmine. A model for predicting which patients would receive neostigmine and sugammadex was generated with an AUC of 0.681 (95% CI: 0.654-0.708), sensitivity of 78% and specificity of 48%. These findings may assist anesthesiologists in identifying which patients are likely to require sugammadex for rescue NMB reversal after use of neostigmine and are therefore suitable candidates for using sugammadex as a first-line therapy.
Methods: the clinico-pathological data of 142 cases of thyroid micropapillary carcinoma were collected, the relationship between sex, age, tumor location, multi-focality and cervical lymph node metastasis was analyzed.
Results: There was a high rate of lymph node metastasis in male patients with PTMC. There was no significant correlation between age, multifocality and lymph node metastasis. Conclusion: The histological subtypes of PTMC have different clinicopathological characteristics and are important factors for cervical lymph node metastasis. Further evaluation of its histological classification is helpful for clinical treatment strategy.
A total of 24 samples of uranium ore were collected from three mines and the lead isotopic ratios and age estimation signatures of the uranium ore mineralisation determined. Inductively Coupled Plasma Mass Spectrometer was employed for sample analysis. 206Pb was abundant in the ore samples and was determined to be geogenic and not anthropogenic. The estimated age of the uranium ore mineralisation was in the range documented for the Namibian Damara Orogen. The studied showed that lead isotopic ratios can provide an estimate of the age of the uranium ore mineralisation and aid as a fool in nuclear forensics.
Key words: Lead isotopic ratios, uranium ore mineralization, nuclear forensics, geochronology
Aims: The purposes of this study were to compare the outcomes of patients receiving neostigmine alone vs. patients receiving neostigmine and sugammadex and to identify the risk factors for patients requiring sugammadex as a rescue neuromuscular blockade reversal agent.
Methods: A retrospective observational study of general anesthesia cases using rocuronium or vecuronium for NMB at a single regional medical center from January 1, 2019 to March 30, 2021 was performed. Demographics, surgical details, and outcomes of patients receiving neostigmine only (N) were compared to those of patients receiving neostigmine followed by sugammadex (NS). A conditional logistic regression model was developed to identify predictors of patients requiring a rescue dose of sugammadex for NMB reversal.
Results: A total of 7104 patients were included (N=6684, NS=420). In comparison to patients in the N group, those in the NS group experienced shorter duration from last NMB administration to first reversal, longer PACU recovery times, longer length of stay, and higher rates of reintubation. After risk adjustment, patients receiving NS were more likely to be female, of non-white race, have increased BMIs, and a greater comorbidity burden than those requiring N only. In comparison to patients undergoing general surgery, those undergoing thoracic surgery are at increased risk for requiring NS. A model for predicting which patients would receive NS was generated with an AUC of 0.681 (95% CI: 0.654-0.708), sensitivity of 78% and specificity of 48%.
Conclusion: These findings may assist anesthesiologists in identifying which patients are likely to require sugammadex for rescue NMB reversal after use of neostigmine and are therefore suitable candidates for using sugammadex as a first-line therapy.
Key Words : Neuromuscular blockade reversal, sugammadex, neostigmine, residual neuromuscular blockade, predictive model
Core Tip: After risk adjustment, patients who were female, of non-white race, have increased BMIs, have a greater comorbidity burden, or undergo thoracic surgery are at increased risk for requiring sugammadex after neostigmine. A model for predicting which patients would receive neostigmine and sugammadex was generated with an AUC of 0.681 (95% CI: 0.654-0.708), sensitivity of 78% and specificity of 48%. These findings may assist anesthesiologists in identifying which patients are likely to require sugammadex for rescue NMB reversal after use of neostigmine and are therefore suitable candidates for using sugammadex as a first-line therapy.