Beginning with a review of the current development of cultural complex theory, this article discu... more Beginning with a review of the current development of cultural complex theory, this article discusses the notions of the "collective psyche: "thin times", the cultural complex as being like a "teratoma" and the major characteristics of cultural complexes. The article is framed in terms of "personal reflections" of Thomas Singer who places the development of the ideas in the context of his personal development as a Jungian analyst. The theory and practice of "cultural complexes" is likened to a cultural circumambulation of highly conflicted political, social, economic and environmental issues in which the search for effective action is always at issue. Much of what tears us apart in the world today can be understood as the manifestation of autonomous processes in the collective and individual psyche that organize themselves as cultural or group complexes—which one can metaphorically imagine as accumulating in the collective psyche much lik...
On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines re... more On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines relating to cardiac proarrhythmic safety, an initiative aims to consider the implementation of a new paradigm that combines in vitro and in silico technologies to improve risk assessment. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative (co-sponsored by the Cardiac Safety Research Consortium, Health and Environmental Sciences Institute, Safety Pharmacology Society and FDA) is a bold and welcome step in using computational tools for regulatory decision making. This review compares and contrasts the state-of-the-art tools from empirical to mechanistic models of cardiac electrophysiology, and how they can and should be used in combination with experimental tests for compound decision making.
Toxicological sciences : an official journal of the Society of Toxicology, May 1, 2017
Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the... more Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the preclinical safety assessment of single-stranded oligonucleotide (SSO) drugs. We evaluated minipigs as a potential alternative to NHPs to test the safety of this class of compounds. Four different phosphorothioated locked nucleic acid-based SSOs (3 antisense and 1 anti-miR), all with known safety profiles, were administered to minipigs using similar study designs and read-outs as in earlier NHP studies with the same compounds. The studies included toxicokinetic investigations, in-life monitoring, clinical and anatomic pathology. In the minipig, we demonstrated target engagement by the SSOs where relevant, and a similar toxicokinetic behavior in plasma, kidney, and liver when compared with NHPs. Clinical tolerability was similar between minipig and NHPs. For the first time, we showed similar and dose-dependent effects on the coagulation and complement cascade after intravenous dosing sim...
How 2 design programs have linked up in developing curriculum and student projects in using colla... more How 2 design programs have linked up in developing curriculum and student projects in using collaborative design methods in the classroom. Project / presentation overview www.designcollaborative.org The design of manufactured parts at times requires a team effort. This team effort may also require having to work with other design teams that are separated by a great distance. Getting design and drafting programs to simulate this type of commercial interaction has been traditionally difficult. Our Design program at Sinclair Community College and the Design programs at Ventura College, and College of the Redwoods have teamed up to develop modular curriculum in collaborative design and created a design "out of the box" style project that can be used by any design or drafting course /program to get started in using collaborative design and working with other design programs.
Beginning with a 'big dream' from almost fifty years ago, this paper tracks movement back and for... more Beginning with a 'big dream' from almost fifty years ago, this paper tracks movement back and forth from an inner/individual adaptation to life to outer/ collective adaptations through various stages of a life's journey. The rhythm between more inner orientation at one stage gives way to more outer adaptation at another stage and vice versa. This same movement can be paralleled by an exclusive emphasis on analysis at one stage and more of a mixture of analysis and activism at another stage. At the heart of this narrative is the realization that an inner big dream of decades before, symbolised both an inner path of developing a relationship with lifepromoting energies and an outer path represented by facilitating others' discovery and participation in those energies. The dream therefore anticipated a more activist future of connecting inner and outer, individual and collective in various professional projects. This has resulted in occasional glimpses of the fact that the 'spirit of the depths' and 'the spirit of the times' can have a common meeting ground.
Abstract “The Meshugana Complex” examines some of the “craziness” of being both Jungian and Jewis... more Abstract “The Meshugana Complex” examines some of the “craziness” of being both Jungian and Jewish. It begins with personal biographical anecdotes showing there are as many ways of being Jewish as there are of being Jungian. The paper then explores group identity as being mediated by complexes that are built up over time, both within the group’s view of itself and of how other groups perceive it. Jewish Jungians carry multiple cultural complexes as part of their identity. The paper concludes with an archetypal perspective, from which the conflict among Jungian, Freudian, and Jewish identities can be imagined as a drop in the bucket in the Jewish mystical tradition of the Kabbalah.
New international trade agreements and institutions will have an important impact on state enviro... more New international trade agreements and institutions will have an important impact on state environmental practices. As states within afederal system become increasingly bound by trade agreements, their involvement in framing international trade rules and policies must increase accordingly. This article sets forth some of the new international obligations that could impinge on state soverignty, and makes recommendations that would bring more accountability and balance to state-federal procedures for addressing these matters.
... Wilhelm Friedrich Hegel: "The story of the Fall shows the universal repercussion of ... more ... Wilhelm Friedrich Hegel: "The story of the Fall shows the universal repercussion of knowledge [connaissance: a noun with many and varied senses in French, including the English sense of carnal knowledge] on spiritual life." In the First Papers show, Duchamp exhibited his ...
Beginning with a review of the current development of cultural complex theory, this article discu... more Beginning with a review of the current development of cultural complex theory, this article discusses the notions of the "collective psyche: "thin times", the cultural complex as being like a "teratoma" and the major characteristics of cultural complexes. The article is framed in terms of "personal reflections" of Thomas Singer who places the development of the ideas in the context of his personal development as a Jungian analyst. The theory and practice of "cultural complexes" is likened to a cultural circumambulation of highly conflicted political, social, economic and environmental issues in which the search for effective action is always at issue. Much of what tears us apart in the world today can be understood as the manifestation of autonomous processes in the collective and individual psyche that organize themselves as cultural or group complexes—which one can metaphorically imagine as accumulating in the collective psyche much lik...
On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines re... more On the tenth anniversary of two key International Conference on Harmonisation (ICH) guidelines relating to cardiac proarrhythmic safety, an initiative aims to consider the implementation of a new paradigm that combines in vitro and in silico technologies to improve risk assessment. The Comprehensive In Vitro Proarrhythmia Assay (CiPA) initiative (co-sponsored by the Cardiac Safety Research Consortium, Health and Environmental Sciences Institute, Safety Pharmacology Society and FDA) is a bold and welcome step in using computational tools for regulatory decision making. This review compares and contrasts the state-of-the-art tools from empirical to mechanistic models of cardiac electrophysiology, and how they can and should be used in combination with experimental tests for compound decision making.
Toxicological sciences : an official journal of the Society of Toxicology, May 1, 2017
Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the... more Non-human primates (NHPs) are currently considered to be the non-rodent species of choice for the preclinical safety assessment of single-stranded oligonucleotide (SSO) drugs. We evaluated minipigs as a potential alternative to NHPs to test the safety of this class of compounds. Four different phosphorothioated locked nucleic acid-based SSOs (3 antisense and 1 anti-miR), all with known safety profiles, were administered to minipigs using similar study designs and read-outs as in earlier NHP studies with the same compounds. The studies included toxicokinetic investigations, in-life monitoring, clinical and anatomic pathology. In the minipig, we demonstrated target engagement by the SSOs where relevant, and a similar toxicokinetic behavior in plasma, kidney, and liver when compared with NHPs. Clinical tolerability was similar between minipig and NHPs. For the first time, we showed similar and dose-dependent effects on the coagulation and complement cascade after intravenous dosing sim...
How 2 design programs have linked up in developing curriculum and student projects in using colla... more How 2 design programs have linked up in developing curriculum and student projects in using collaborative design methods in the classroom. Project / presentation overview www.designcollaborative.org The design of manufactured parts at times requires a team effort. This team effort may also require having to work with other design teams that are separated by a great distance. Getting design and drafting programs to simulate this type of commercial interaction has been traditionally difficult. Our Design program at Sinclair Community College and the Design programs at Ventura College, and College of the Redwoods have teamed up to develop modular curriculum in collaborative design and created a design "out of the box" style project that can be used by any design or drafting course /program to get started in using collaborative design and working with other design programs.
Beginning with a 'big dream' from almost fifty years ago, this paper tracks movement back and for... more Beginning with a 'big dream' from almost fifty years ago, this paper tracks movement back and forth from an inner/individual adaptation to life to outer/ collective adaptations through various stages of a life's journey. The rhythm between more inner orientation at one stage gives way to more outer adaptation at another stage and vice versa. This same movement can be paralleled by an exclusive emphasis on analysis at one stage and more of a mixture of analysis and activism at another stage. At the heart of this narrative is the realization that an inner big dream of decades before, symbolised both an inner path of developing a relationship with lifepromoting energies and an outer path represented by facilitating others' discovery and participation in those energies. The dream therefore anticipated a more activist future of connecting inner and outer, individual and collective in various professional projects. This has resulted in occasional glimpses of the fact that the 'spirit of the depths' and 'the spirit of the times' can have a common meeting ground.
Abstract “The Meshugana Complex” examines some of the “craziness” of being both Jungian and Jewis... more Abstract “The Meshugana Complex” examines some of the “craziness” of being both Jungian and Jewish. It begins with personal biographical anecdotes showing there are as many ways of being Jewish as there are of being Jungian. The paper then explores group identity as being mediated by complexes that are built up over time, both within the group’s view of itself and of how other groups perceive it. Jewish Jungians carry multiple cultural complexes as part of their identity. The paper concludes with an archetypal perspective, from which the conflict among Jungian, Freudian, and Jewish identities can be imagined as a drop in the bucket in the Jewish mystical tradition of the Kabbalah.
New international trade agreements and institutions will have an important impact on state enviro... more New international trade agreements and institutions will have an important impact on state environmental practices. As states within afederal system become increasingly bound by trade agreements, their involvement in framing international trade rules and policies must increase accordingly. This article sets forth some of the new international obligations that could impinge on state soverignty, and makes recommendations that would bring more accountability and balance to state-federal procedures for addressing these matters.
... Wilhelm Friedrich Hegel: "The story of the Fall shows the universal repercussion of ... more ... Wilhelm Friedrich Hegel: "The story of the Fall shows the universal repercussion of knowledge [connaissance: a noun with many and varied senses in French, including the English sense of carnal knowledge] on spiritual life." In the First Papers show, Duchamp exhibited his ...
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