International Journal of Research in Ayurveda & Pharmacy, 2016
The traditional system of medicine has developed faith and pronounced as effective and safe metho... more The traditional system of medicine has developed faith and pronounced as effective and safe method of treatment. Mucuna pruriens use to treat impotence, diabetes mellitus and has anti-ulcer activity. On the other side NSAID's (Non-Steroidal Anti-inflammatory Drugs) is popular group of medicament use to treat inflammation and pain. Aspirin is the most common NASID in the practice which is well known to cause gastrointestinal ulcers. To evaluate the antiulcer activity of aqueous extract of Mucuna pruriens in aspirin induced ulcers. Preparation of extracts separately with Petroleum ether, alcohol and water. A total of thirty adult albino wistar rats were divided into four groups to evaluate the anti-ulcer effect. Group 1 Aspirin control (150 mg/kg) Group 2 Aspirin + Standard drug (Pantoprazole 40 mg/kg/per oral) Group 3 Aspirin + Mucuna pruriens aqueous extract (200mg/kg body weight) Group 4: Aspirin + Mucuna pruriens aqueous extract (400mg/kg body weight). The aqueous extract of Mucuna pruriens showed a dosedependent protection against Aspirin induced gastric ulceration. The extract protected the rat stomach from ulceration by 58.3% at a dose of 200 mg/kg body wt. (P≤0.001) and this increased to 86.8 (P≤0.001) at 400 mg/kg body wt. as compared to solvent treated rats, respectively. This was the same percentage protection as 40 mg/kg body wt. of the proton pump inhibitor like pantoprazole. Mucuna pruriens showed significant antiulcer activity in experimentally induced ulcer in rat model by decreasing the gastric secretions and by enhancing glycoprotein levels.
A new phenolic glucoside, (rel)-2-(4',6'-dibenzoyl-β-glucopyranosyloxy)-7-(1α-hydroxy-2α-ethoxy-6... more A new phenolic glucoside, (rel)-2-(4',6'-dibenzoyl-β-glucopyranosyloxy)-7-(1α-hydroxy-2α-ethoxy-6α-acetyloxy-3oxocyclohex-4-enoyl)-benzyl alcohol (Flacourticin) (1) and the known, 2-(4',6'-dibenzoyl-β-glucopyranosyl)-5-hydroxy benzyl alcohol (4'-benzoylpoliothrysoside) (2) together with the new, (2E)-heptyl-3-(3,4-dihydroxyphenyl) acrylate (3), (+)-catechin (4) and sitosterol-β-D-glucoside were isolated from Flacourtia indica. Their structures were assigned on the basis of 1D, 2D-NMR and as well by analysis of the LC-ESIMS data. The isolated compounds (1-4) were evaluated for α,αdiphenyl-β-picrylhydrazyl (DPPH) radical scavenging activity, and 3 was found to be twofold less potent, with an IC 50 =12.01 μg/mL, compared to the positive control, Rutin, (IC 50 = 5.83 μg/mL).
Purpose: To carry out a bioactivity guided fractionation and isolation of the antimicrobial const... more Purpose: To carry out a bioactivity guided fractionation and isolation of the antimicrobial constituent(s) of the roots of Flemingia strobilifera against some bacteria and fungi. Methods: The root of F. strobilifera was extracted with methanol, butanol and dichloromethane. Antimicrobial activity of the extracts was determined against both bacteria and fungi while the isolation and characterization of compounds of the extracts was done by column chromatography,2D spectroscopic studies and spectral data (U.V, I.R, NMR and MS). Results: Flemingiaflavanone (8, 3 '-diprenyl-5, 7, 4 '-trihydroxy flavanone), Genistin (5, 4 'dihydroxy isoflavone 7-O-glucoside) and β-sitosterol-D glucoside were isolated from the extracts. Flemingiaflavanone showed significant antimicrobial activity against Gram-positive (S. aureus, S. epidermidis, MRSA), Gram-negative bacteria (Ps. aeruginosa, E. coli) and fungi (C. albicans). Genistin showed moderate activity against Gram-positive, Gram-negative bacteria and fungi. Conclusions: The isolation and antimicrobial activity of presence of Flemingiaflavanone is being reported for the first time.
A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified ... more A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified as 5,7,4'-trihydroxy…
Cuscuta reflexa belongs to the family Convolvulaceae is indigenous medicinal plant and is a well-... more Cuscuta reflexa belongs to the family Convolvulaceae is indigenous medicinal plant and is a well-known folklore remedy for the treatment of liver disorder. Present work deals with the comparative standardization of Cuscuta reflexa growing on different host plants i.e. Alstonia scholaris and Ficus virens by using pharmacognostic and phytochemical investigation of whole plant. The whole plant was extracted with different organic solvents in increasing order of polarity. The results of the preliminary investigation revealed the presence of flavonoids, glycosides & carbohydrates. The methanolic, ethanolic and aqueous extracts of the plant growing on different host plants were investigated by using thin layer chromatography. The aim of the present study was focused on the pharmacognostical and phytochemical properties, which would like to facilitate quick identification and selection of the drug from various adulterates. All the parameters were studied according to the WHO and Pharmacopo...
International Journal of Research in Ayurveda & Pharmacy, 2016
The traditional system of medicine has developed faith and pronounced as effective and safe metho... more The traditional system of medicine has developed faith and pronounced as effective and safe method of treatment. Mucuna pruriens use to treat impotence, diabetes mellitus and has anti-ulcer activity. On the other side NSAID's (Non-Steroidal Anti-inflammatory Drugs) is popular group of medicament use to treat inflammation and pain. Aspirin is the most common NASID in the practice which is well known to cause gastrointestinal ulcers. To evaluate the antiulcer activity of aqueous extract of Mucuna pruriens in aspirin induced ulcers. Preparation of extracts separately with Petroleum ether, alcohol and water. A total of thirty adult albino wistar rats were divided into four groups to evaluate the anti-ulcer effect. Group 1 Aspirin control (150 mg/kg) Group 2 Aspirin + Standard drug (Pantoprazole 40 mg/kg/per oral) Group 3 Aspirin + Mucuna pruriens aqueous extract (200mg/kg body weight) Group 4: Aspirin + Mucuna pruriens aqueous extract (400mg/kg body weight). The aqueous extract of Mucuna pruriens showed a dosedependent protection against Aspirin induced gastric ulceration. The extract protected the rat stomach from ulceration by 58.3% at a dose of 200 mg/kg body wt. (P≤0.001) and this increased to 86.8 (P≤0.001) at 400 mg/kg body wt. as compared to solvent treated rats, respectively. This was the same percentage protection as 40 mg/kg body wt. of the proton pump inhibitor like pantoprazole. Mucuna pruriens showed significant antiulcer activity in experimentally induced ulcer in rat model by decreasing the gastric secretions and by enhancing glycoprotein levels.
A new phenolic glucoside, (rel)-2-(4',6'-dibenzoyl-β-glucopyranosyloxy)-7-(1α-hydroxy-2α-ethoxy-6... more A new phenolic glucoside, (rel)-2-(4',6'-dibenzoyl-β-glucopyranosyloxy)-7-(1α-hydroxy-2α-ethoxy-6α-acetyloxy-3oxocyclohex-4-enoyl)-benzyl alcohol (Flacourticin) (1) and the known, 2-(4',6'-dibenzoyl-β-glucopyranosyl)-5-hydroxy benzyl alcohol (4'-benzoylpoliothrysoside) (2) together with the new, (2E)-heptyl-3-(3,4-dihydroxyphenyl) acrylate (3), (+)-catechin (4) and sitosterol-β-D-glucoside were isolated from Flacourtia indica. Their structures were assigned on the basis of 1D, 2D-NMR and as well by analysis of the LC-ESIMS data. The isolated compounds (1-4) were evaluated for α,αdiphenyl-β-picrylhydrazyl (DPPH) radical scavenging activity, and 3 was found to be twofold less potent, with an IC 50 =12.01 μg/mL, compared to the positive control, Rutin, (IC 50 = 5.83 μg/mL).
Purpose: To carry out a bioactivity guided fractionation and isolation of the antimicrobial const... more Purpose: To carry out a bioactivity guided fractionation and isolation of the antimicrobial constituent(s) of the roots of Flemingia strobilifera against some bacteria and fungi. Methods: The root of F. strobilifera was extracted with methanol, butanol and dichloromethane. Antimicrobial activity of the extracts was determined against both bacteria and fungi while the isolation and characterization of compounds of the extracts was done by column chromatography,2D spectroscopic studies and spectral data (U.V, I.R, NMR and MS). Results: Flemingiaflavanone (8, 3 '-diprenyl-5, 7, 4 '-trihydroxy flavanone), Genistin (5, 4 'dihydroxy isoflavone 7-O-glucoside) and β-sitosterol-D glucoside were isolated from the extracts. Flemingiaflavanone showed significant antimicrobial activity against Gram-positive (S. aureus, S. epidermidis, MRSA), Gram-negative bacteria (Ps. aeruginosa, E. coli) and fungi (C. albicans). Genistin showed moderate activity against Gram-positive, Gram-negative bacteria and fungi. Conclusions: The isolation and antimicrobial activity of presence of Flemingiaflavanone is being reported for the first time.
A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified ... more A new isoflavone (1) isolated from the roots of Flemingia strobilifera (L) R. Br. was identified as 5,7,4'-trihydroxy…
Cuscuta reflexa belongs to the family Convolvulaceae is indigenous medicinal plant and is a well-... more Cuscuta reflexa belongs to the family Convolvulaceae is indigenous medicinal plant and is a well-known folklore remedy for the treatment of liver disorder. Present work deals with the comparative standardization of Cuscuta reflexa growing on different host plants i.e. Alstonia scholaris and Ficus virens by using pharmacognostic and phytochemical investigation of whole plant. The whole plant was extracted with different organic solvents in increasing order of polarity. The results of the preliminary investigation revealed the presence of flavonoids, glycosides & carbohydrates. The methanolic, ethanolic and aqueous extracts of the plant growing on different host plants were investigated by using thin layer chromatography. The aim of the present study was focused on the pharmacognostical and phytochemical properties, which would like to facilitate quick identification and selection of the drug from various adulterates. All the parameters were studied according to the WHO and Pharmacopo...
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Papers by Swati Madan