V. Latorre

Followers

Following

Co-authors

Public Views

M. Comabella

Ricardo Palacios

University of Zaragoza

University of Sao Paulo

Reza Jabal

Newcastle University

Carlos José Sousa Passos

Universidade de Brasília - UnB

David Booth

Sandra Cabrera

Interests

Uploads

Papers by V. Latorre

Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study

by V. Latorre, Antonella La Russa, and Francesca Trecroci

Journal of Neuroimmunology, 2010

To investigate the role of the matrix metalloproteinase-9 gene (MMP-9) in multiple sclerosis (MS)... more To investigate the role of the matrix metalloproteinase-9 gene (MMP-9) in multiple sclerosis (MS), we analyzed the functional − 1562C/T and − 90 (CA) n repeat polymorphisms in 243 Italian patients with MS and 173 healthy controls. A significant increase of the − 1562T allele carriers was found in patients with MS compared to controls. Moreover, haplotype analysis showed that the haplotype formed by the − 1562T allele and the L allele ((CA) ≤ 20 ) was over-represented in patients with MS versus controls. These results suggest that a genetic polymorphism of the MMP-9 promoter region may influence the susceptibility to MS.

Download

Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance

Psychiatry Research: Neuroimaging, 2006

Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dor... more Earlier studies with functional imaging in schizophrenia have demonstrated dysfunction of the dorsolateral prefrontal cortex during working memory. Controlling for behavioral performance and for catechol-O-methyltransferase (COMT) Val158Met genotype, we here demonstrate in a functional magnetic resonance imaging paradigm that patients recruit greater neuronal resources in prefrontal cortex during working memory, suggesting that this phenotype is a core functional trait of the disease. We also replicated earlier findings that the Val allele of the COMT polymorphism is associated with greater engagement of the prefrontal cortex.

Replication of Neuroblastoma SNP Association at the BARD1 Locus in African-Americans

Cancer Epidemiology Biomarkers & Prevention, 2012

Background: Neuroblastoma is an often fatal pediatric cancer more frequent in European-American t... more Background: Neuroblastoma is an often fatal pediatric cancer more frequent in European-American than African-American children. African-American children, however, are at higher risk for the more severe form of neuroblastoma and have worse overall survival than European-American children. Genome-wide association studies (GWAS) have identified several single-nucleotide polymorphisms (SNP) associated to neuroblastoma in children of European descent. Knowledge of their association to neuroblastoma in African-American children is still lacking.

Download

CASP-9: A susceptibility locus for multiple sclerosis in Italy

by Rita Nisticò, Antonella La Russa, V. Latorre, R. Cittadella, and Francesca Trecroci

Journal of Neuroimmunology, 2009

Caspase-9 is a primary effector CASP that executes programmed cell death, which plays an importan... more Caspase-9 is a primary effector CASP that executes programmed cell death, which plays an important role in the development of multiple sclerosis (MS). Polymorphisms in the CASP-9 gene may influence its activity, thereby modulating the susceptibility to MS. To test this hypothesis, we evaluated a SNP in the CASP-9 gene in a set of Italian patients from Southern Italy and healthy control subjects. Our results suggest that the presence of the G/G genotype represents a higher risk factor in our MS population and a differential production of CASP-9 might be a contributory factor in determining the severity of MS.

Download

Single nucleotide polymorphism in the MMP-9 gene is associated with susceptibility to develop multiple sclerosis in an Italian case-control study

by V. Latorre, Antonella La Russa, and Francesca Trecroci

Journal of Neuroimmunology, 2010

Download

Prefrontal dysfunction in schizophrenia controlling for COMT Val158Met genotype and working memory performance

Psychiatry Research: Neuroimaging, 2006