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Xinwei Zhang

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Y Tantirungrotechai

merlyn pulikkathara

Rice University

Jerzy P Lukaszewicz

Nicolaus Copernicus University

Jerzy Leszczynski

Jackson State University

Ruhr-Universität Bochum

Institute of Physical Chemistry PAS

Silvia Giordani

Trinity College Dublin

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Papers by Xinwei Zhang

Structural evolution of [2+1] cycloaddition derivatives of single-wall carbon nanotubes: From open structure to closed three-membered ring structure with increasing tube diameter

Journal of Molecular Structure-theochem, 2005

By using density functional theory calculations, it is found that the [2+1] cycloaddition derivat... more By using density functional theory calculations, it is found that the [2+1] cycloaddition derivatives of armchair (m,m) single-wall carbon nanotube (SWNT) evolve from open structure to closed three-membered ring structure as m>11 for NH addition, m>10 for O and CH2 additions, and m>5 for SiH2 addition. The diameter upper limit of the opening of the sidewall of SWNTs upon [2+1]

Characterizations of BC501A and BC537 liquid scintillator detectors

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Jan 19, 2015

Two 2″×2″ liquid scintillator detectors BC537 and BC501A have been characterized for their respon... more Two 2″×2″ liquid scintillator detectors BC537 and BC501A have been characterized for their responses and efficiencies to γ-ray detection. Light output resolution and response functions were derived by least-squares minimization of a simulated response function, fitted to experimental data. The γ-ray response matrix and detection efficiency were simulated with Monte Carlo (MC) methods and validated. For photon energies below 2.4MeVee, the resolution, as well as the efficiency, of BC501A is better than BC537 scintillator. The situation is reversed when the energy is higher than 2.4MeVee. BC537 has higher γ-ray detection efficiency than BC501A if the impinging photon energy is more than 2MeV due to different ratios of C to H/D atoms.

Theoretical identification of C 20 carbon clusters: Prevalence of the monocyclic isomer and existence of the smallest fullerene and bowl isomer

Physical Review B, 2003

Free energies, electron affinities, and vibrational progressions have been investigated for sever... more

Season and outdoor temperature in relation to detection and control of hypertension in a large rural Chinese population

International journal of epidemiology, 2014

In many Western populations, blood pressure varies moderately with season and outdoor temperature... more In many Western populations, blood pressure varies moderately with season and outdoor temperature. Relatively little is known about effects of seasonal changes in blood pressure on the detection and control of hypertension in general populations, especially in low- and middle-income countries. We analysed cross-sectional data of 57 375 (42% men) participants aged 30-79 (mean 52.3) years who were enrolled during 2004-08, as part of the China Kadoorie Biobank, from a rural county in the south-east costal Zhejiang Province. Analyses related daily mean outdoor temperature, obtained from local Meteorological Bureau, to mean systolic (SBP) and diastolic blood pressure (DBP), rate of newly detected hypertension and, among those with self-reported physician-diagnosed hypertension, rate of adequate blood pressure control, using multiple linear and logistic regression models. The overall mean blood pressure was 135.9 mmHg for SBP and 80.5 mmHg for DBP. Daily outdoor temperature ranged between...

The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size

by Xinwei Zhang and Georg Halder

Current Biology, 2006

Evolution of the Electronic Properties of Metallic Single-Walled Carbon Nanotubes with the Degree of CCl 2 Covalent Functionalization

The Journal of Physical Chemistry B, 2006

The changes in energetic, structural, and electronic properties of the metallic (5,5) single-wall... more The changes in energetic, structural, and electronic properties of the metallic (5,5) single-walled carbon nanotube (SWNT) with the degree of sidewall covalent functionalization of CCl(2) are investigated extensively by using density functional theory calculations. The saturation concentration of CCl(2) covalent functionalization is predicted to be 33.3%. The cycloadducts always adopt an open structure. A band gap opens as the functionalization concentration reaches 11% and then basically increases with increasing functionalization concentration. These results are in agreement with available experiments and can be applied to accurately predict the band gap of metallic SWNTs produced by the HiPco method at a given CCl(2) functionalization concentration.

Electronic structures of endohedral Ca@C60, Sc@C60 and Y@C60

Solid State Communications, 1999

Discrete-variational local density functional calculations on endohedral Ca@ C60, Sc@ C60 and Y@ ... more

Structural and electronic properties of oxygen-doped heterofullerene: is the O–C single bond shorter than the C–C single bond?

Solid State Communications, 2001

Single O-doped heterofullerene C 59 O is investigated via semiempirical PM3 calculations. In cont... more Single O-doped heterofullerene C 59 O is investigated via semiempirical PM3 calculations. In contrast to previous less accurate INDO/2 calculations where the O±C single bond is shorter than the C±C single bond of the fullerene cage, our static geometric optimization obtained a slightly longer O±C single bond, a general result for heterofullerenes. The HOMO lies in the middle of the energy gap of the undoped system, and its probability density is strongly localized on the dopant O site. Also investigated are the geometric and electronic properties of the C 58 O 2 isomer with two doped O atoms occupying the paravertexes of a hexagon. q

Interplay of single-wall carbon nanotubes and encapsulated La@C82, La2@C80, and Sc3N@C80

Physical Review B, 2005

... of 220 eV and two k points, and terminated until all forces are less than ... The local densi... more

Article The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway

Summary Background: The Hippo tumor-suppressor pathway has emerged as a key signaling pathway tha... more Summary Background: The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size inDrosophila. Hippo signaling restricts tissue size by promoting apoptosis and cell-cycle arrest, and animals carrying clones of cells mutant for hippo de- velop severely overgrown adult structures. The Hippo pathway is thought to exert its effects by modulating gene expression through the phosphorylation of the transcriptional coactivator Yorkie. However, how Yorkie regulates growth, and thus the identities of downstream target genes that mediate the effects of Hippo signaling, are largely unknown. Results: Here, we report that the bantam microRNA is a downstream target of the Hippo signaling pathway. In common with Hippo signaling, the bantam microRNA controls tissue size by regulating cell proliferation and apoptosis. We found that hippo mutant cells had ele- vated levels of bantam activity and that bantam was required for Yorkie-driven overgrowth. Additionally,...

Structural and electronic properties of heterofullerene C 59 P

Molecular Physics, 2001

Single P-doped heterofullerene C59P is investigated via semiempirical and density functional theo... more Single P-doped heterofullerene C59P is investigated via semiempirical and density functional theory calculations. Static geometric optimization shows that structural deformation occurs in the vicinity of the dopant atom and gives rise to P< bonds significantly larger than the ordinary C--C bonds of the fullerene cage. The HOMO and LUMO lie in the middle of the energy gap of the undoped system. Unlike the HOMOS and LUMOs of C$3i and C59N, which are strongly localized on the dopant site, the CS9P HOMO and LUMO are weakly localized on the environment of the dopant site. To a first good approximation the dopant P can be considered in the 1 + charge state.

The expression of iASPP in acute leukemias

Leukemia Research, 2005

Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and... more Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and its expression is upregulated in human breast carcinomas expressing wild-type p53. To examine the role of iASPP in acute leukemia (AL), we analyzed iASPP mRNA expression in AL by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). PCR products were confirmed by restriction endonuclease BstX I digestion and sequencing analysis. The results showed that median levels of iASPP gene expression in cells of AL were significantly higher than those in cells from normal donors and AL patients in complete remission (CR) (P = 0.019, 0.021, respectively). There was no significant difference between acute lymphocytic leukemia (ALL) cells and acute myeloid leukemia (AML) cells (P = 0.593). The expression level of iASPP gene and its overexpression in M3 and M4EO were significantly lower than in other subtypes of AML. However, iASPP gene expression in AL cells was not associated with gender, age, initial white blood cell count or p53 type, but was associated with CD34 expression. The results of the present study suggest that iASPP gene overexpression may play an important role in the leukemogenesis and/or disease progression of AL.

Analysis of FLT3 internal tandem duplication and D835 mutations in Chinese acute leukemia patients

Leukemia Research, 2005

Genomic aberrations of Fms-like tyrosine kinase 3 (FLT3), including internal tandem duplication (... more Genomic aberrations of Fms-like tyrosine kinase 3 (FLT3), including internal tandem duplication (ITD) and point mutations, have been demonstrated in 25-30% of adults acute myeloid leukemia (AML) and are markers of poor prognosis. FLT3/ITD and D835 mutations were analyzed in 194 Chinese patients with acute leukemia and myelodysplastic syndromes (MDS) by polymerase chain reaction (PCR). FLT3/ITDs and D835 mutations were found in 25.9 and 6.3% of 143 AML patients, respectively. Two patients showed both ITD and point mutations. Among the FAB subtypes of AML, the rate of FLT3 aberration was significantly higher in M3 and M5. However, neither aberrations was found in 25 patients with acute lymphoblastic leukemia (ALL), 2 acute hybrid leukemia, 17 MDS and 7 chronic myeloid leukemia in blast crisis (CML-BC). FLT3/ITD was associated to leukocytosis and lower complete remission (CR) rate, and was more prevalent in patients with normal karyotype. In contrast, D835 mutation was not associated with leukocytosis or low CR rate. Our results confirm that FLT3 activating mutations also occur in a significant percentage in Chinese AML patients. FLT3/ITD(+) patients treated with standard induction regimen could achieve lower complete remission rates compared with patients not harboring this defect. Early detection of FLT3 mutations and an intensification of induction therapy might thus be useful for this group of patients to overcome the poor prognosis.

siRNA-mediated down-regulation of iASPP promotes apoptosis induced by etoposide and daunorubicin in leukemia cells expressing wild-type p53

by Xinwei Zhang and Jumin Wang

Leukemia Research, 2009

Oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of tumor suppressor p... more Oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of tumor suppressor p53. Our previous study revealed that the expression of iASPP in acute leukemia (AL) patients was higher than that of normal control which implied that iASPP might play an important role in the pathogenesis and/or disease progression of AL. In this study, the iASPP expression was blocked by RNA interference (RNAi) in two leukemic cell lines, Nalm6 and K562, to explore the effects of iASPP on leukemia cells. The results indicated that down-regulation of endogenous iASPP increased p53-dependent apoptosis of leukemia cells. Thus, iASPP could be a molecular target in leukemia therapy.

Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia

Leukemia Research, 2003

We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosom... more We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission (CR) after treatment with interferon (IFN). When he transformed to acute lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was normal and fluorescence in situ hybridization (FISH) indicated that blast cells were Ph-negative. Immunophenotyping showed that the cells were CD34-positive and CD38-negative. Blast cells in his final stage were BCR/ABL rearrangement negative by reverse transcription polymerase chain reaction (RT-PCR).

Selective Interaction of Large or Charge-Transfer Aromatic Molecules with Metallic Single-Wall Carbon Nanotubes: Critical Role of the Molecular Size and Orientation

Journal of the American Chemical Society, 2006

Using first principles calculations, we report for the first time that large nearly neutral aroma... more Using first principles calculations, we report for the first time that large nearly neutral aromatic molecules, such as naphthalene and anthracene, and small charge-transfer aromatic molecules, such as TCNQ and DDQ, interact more strongly with metallic single-wall carbon nanotubes (SWNTs) versus their semiconducting counterparts as the molecular orientation of DDQ is taken into account. Hence two new mechanisms for separating metallic and semiconducting SWNTs via noncovalent π-π stacking or chargetransfer interaction are suggested.

Large-Scale Separation of Metallic and Semiconducting Single-Walled Carbon Nanotubes

Journal of the American Chemical Society, 2005

In the applications of single-walled carbon nanotubes (SWNTs), it is extremely important to separ... more In the applications of single-walled carbon nanotubes (SWNTs), it is extremely important to separate semiconducting and metallic SWNTs. Although several methods have been reported for the separation, only low yields have been achieved at great expense. We show a separation method involving a dispersion-centrifugation process in a tetrahydrofuran solution of amine, which makes metallic SWNTs highly concentrated to 87% in a simple way.

Sulfated SnO2 modified multi-walled carbon nanotubes – A mixed proton–electron conducting support for Pt catalysts in direct ethanol fuel cells

Journal of Power Sources, 2011

We report on the synthesis of sulfated SnO 2 modified multi-walled carbon nanotubes (MWCNTs) comp... more We report on the synthesis of sulfated SnO 2 modified multi-walled carbon nanotubes (MWCNTs) composites as new supports of Pt catalyst (Pt-S-SnO 2 /MWCNTs) with the aims to enhance electron and proton conductivity and also catalytic activity for ethanol oxidation. The Pt-S-SnO 2 /MWCNTs catalyst is synthesized by a combination of improved sol-gel and pulse-microwave assisted polyol methods. The surface presence, morphology and structure of the Pt-S-SnO 2 /MWCNTs catalyst are characterized by Fourier transform infrared spectroscopy (FT-IR), high-resolution transmission electron microscopy (HRTEM) and X-ray diffraction (XRD), respectively. The electrocatalytic properties of the Pt-S-SnO 2 /MWCNTs catalyst for ethanol oxidation reactions are investigated by cyclic voltammetry, chronoamperometry and electrochemical impedance spectroscopy. The results show that Pt-S-SnO 2 /MWCNTs catalyst exhibits higher catalytic activity for ethanol oxidation than Pt supported on non-sulfated SnO 2 /MWCNTs composites.

Identification of a Novel Isoform of iASPP and its Interaction with p53

Journal of Molecular Biology, 2007

iASPP is an inhibitory member of ASPP (apoptosis stimulating protein of p53, or Ankyrin repeats, ... more iASPP is an inhibitory member of ASPP (apoptosis stimulating protein of p53, or Ankyrin repeats, SH3 domain and proline-rich region contain Protein) family. As reported previously, it at least includes two isoforms, one is iASPP/RAI (351 amino acids, aa) and the other is iASPP (828 aa). Here, we identified a novel open reading frame of human iASPP, which encodes a 407 aa protein and highly matches with the C terminus of iASPP (828 aa, CAI60219). Hereafter, iASPP (407 aa) will be referred to as iASPP-SV (iASPP splice variant). In further study, we found that iASPP-SV is a nuclear protein, and is capable of binding to p53 in vivo. Moreover, overexpression of iASPP-SV can inhibit the transcriptional activity of p53 on the promoters of both Bax and p21.

An efficient numerical method of Landau–Brazovskii model

Journal of Computational Physics, 2008

Using the Landau-Brazovskii model, a new numerical implementation is developed to investigate the... more Using the Landau-Brazovskii model, a new numerical implementation is developed to investigate the phase behavior of the diblock copolymer system. Though the method is based on the Fourier expansion of order parameter, a priori symmetric information is not required, and more significantly, the period structure can be adjusted automatically during the iteration as well. The method enables us to calculate the phase diagram, discover new meta-stable phases, validate the epitaxial relation in the phase transition process, and find the inefficiency of the Landau-Brazovskii model for some situations.

Structural evolution of [2+1] cycloaddition derivatives of single-wall carbon nanotubes: From open structure to closed three-membered ring structure with increasing tube diameter

Journal of Molecular Structure-theochem, 2005

By using density functional theory calculations, it is found that the [2+1] cycloaddition derivat... more By using density functional theory calculations, it is found that the [2+1] cycloaddition derivatives of armchair (m,m) single-wall carbon nanotube (SWNT) evolve from open structure to closed three-membered ring structure as m>11 for NH addition, m>10 for O and CH2 additions, and m>5 for SiH2 addition. The diameter upper limit of the opening of the sidewall of SWNTs upon [2+1]

Characterizations of BC501A and BC537 liquid scintillator detectors

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine, Jan 19, 2015

Two 2″×2″ liquid scintillator detectors BC537 and BC501A have been characterized for their respon... more Two 2″×2″ liquid scintillator detectors BC537 and BC501A have been characterized for their responses and efficiencies to γ-ray detection. Light output resolution and response functions were derived by least-squares minimization of a simulated response function, fitted to experimental data. The γ-ray response matrix and detection efficiency were simulated with Monte Carlo (MC) methods and validated. For photon energies below 2.4MeVee, the resolution, as well as the efficiency, of BC501A is better than BC537 scintillator. The situation is reversed when the energy is higher than 2.4MeVee. BC537 has higher γ-ray detection efficiency than BC501A if the impinging photon energy is more than 2MeV due to different ratios of C to H/D atoms.

Theoretical identification of C 20 carbon clusters: Prevalence of the monocyclic isomer and existence of the smallest fullerene and bowl isomer

Physical Review B, 2003

Free energies, electron affinities, and vibrational progressions have been investigated for sever... more

Season and outdoor temperature in relation to detection and control of hypertension in a large rural Chinese population

International journal of epidemiology, 2014

In many Western populations, blood pressure varies moderately with season and outdoor temperature... more In many Western populations, blood pressure varies moderately with season and outdoor temperature. Relatively little is known about effects of seasonal changes in blood pressure on the detection and control of hypertension in general populations, especially in low- and middle-income countries. We analysed cross-sectional data of 57 375 (42% men) participants aged 30-79 (mean 52.3) years who were enrolled during 2004-08, as part of the China Kadoorie Biobank, from a rural county in the south-east costal Zhejiang Province. Analyses related daily mean outdoor temperature, obtained from local Meteorological Bureau, to mean systolic (SBP) and diastolic blood pressure (DBP), rate of newly detected hypertension and, among those with self-reported physician-diagnosed hypertension, rate of adequate blood pressure control, using multiple linear and logistic regression models. The overall mean blood pressure was 135.9 mmHg for SBP and 80.5 mmHg for DBP. Daily outdoor temperature ranged between...

The Fat Cadherin Acts through the Hippo Tumor-Suppressor Pathway to Regulate Tissue Size

by Xinwei Zhang and Georg Halder

Current Biology, 2006

Evolution of the Electronic Properties of Metallic Single-Walled Carbon Nanotubes with the Degree of CCl 2 Covalent Functionalization

The Journal of Physical Chemistry B, 2006

The changes in energetic, structural, and electronic properties of the metallic (5,5) single-wall... more The changes in energetic, structural, and electronic properties of the metallic (5,5) single-walled carbon nanotube (SWNT) with the degree of sidewall covalent functionalization of CCl(2) are investigated extensively by using density functional theory calculations. The saturation concentration of CCl(2) covalent functionalization is predicted to be 33.3%. The cycloadducts always adopt an open structure. A band gap opens as the functionalization concentration reaches 11% and then basically increases with increasing functionalization concentration. These results are in agreement with available experiments and can be applied to accurately predict the band gap of metallic SWNTs produced by the HiPco method at a given CCl(2) functionalization concentration.

Electronic structures of endohedral Ca@C60, Sc@C60 and Y@C60

Solid State Communications, 1999

Discrete-variational local density functional calculations on endohedral Ca@ C60, Sc@ C60 and Y@ ... more

Structural and electronic properties of oxygen-doped heterofullerene: is the O–C single bond shorter than the C–C single bond?

Solid State Communications, 2001

Single O-doped heterofullerene C 59 O is investigated via semiempirical PM3 calculations. In cont... more Single O-doped heterofullerene C 59 O is investigated via semiempirical PM3 calculations. In contrast to previous less accurate INDO/2 calculations where the O±C single bond is shorter than the C±C single bond of the fullerene cage, our static geometric optimization obtained a slightly longer O±C single bond, a general result for heterofullerenes. The HOMO lies in the middle of the energy gap of the undoped system, and its probability density is strongly localized on the dopant O site. Also investigated are the geometric and electronic properties of the C 58 O 2 isomer with two doped O atoms occupying the paravertexes of a hexagon. q

Interplay of single-wall carbon nanotubes and encapsulated La@C82, La2@C80, and Sc3N@C80

Physical Review B, 2005

... of 220 eV and two k points, and terminated until all forces are less than ... The local densi... more

Article The bantam MicroRNA Is a Target of the Hippo Tumor-Suppressor Pathway

Summary Background: The Hippo tumor-suppressor pathway has emerged as a key signaling pathway tha... more Summary Background: The Hippo tumor-suppressor pathway has emerged as a key signaling pathway that controls tissue size inDrosophila. Hippo signaling restricts tissue size by promoting apoptosis and cell-cycle arrest, and animals carrying clones of cells mutant for hippo de- velop severely overgrown adult structures. The Hippo pathway is thought to exert its effects by modulating gene expression through the phosphorylation of the transcriptional coactivator Yorkie. However, how Yorkie regulates growth, and thus the identities of downstream target genes that mediate the effects of Hippo signaling, are largely unknown. Results: Here, we report that the bantam microRNA is a downstream target of the Hippo signaling pathway. In common with Hippo signaling, the bantam microRNA controls tissue size by regulating cell proliferation and apoptosis. We found that hippo mutant cells had ele- vated levels of bantam activity and that bantam was required for Yorkie-driven overgrowth. Additionally,...

Structural and electronic properties of heterofullerene C 59 P

Molecular Physics, 2001

Single P-doped heterofullerene C59P is investigated via semiempirical and density functional theo... more Single P-doped heterofullerene C59P is investigated via semiempirical and density functional theory calculations. Static geometric optimization shows that structural deformation occurs in the vicinity of the dopant atom and gives rise to P< bonds significantly larger than the ordinary C--C bonds of the fullerene cage. The HOMO and LUMO lie in the middle of the energy gap of the undoped system. Unlike the HOMOS and LUMOs of C$3i and C59N, which are strongly localized on the dopant site, the CS9P HOMO and LUMO are weakly localized on the environment of the dopant site. To a first good approximation the dopant P can be considered in the 1 + charge state.

The expression of iASPP in acute leukemias

Leukemia Research, 2005

Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and... more Inhibitory member of the ASPP family (iASPP) is an evolutionarily conserved inhibitor of p53, and its expression is upregulated in human breast carcinomas expressing wild-type p53. To examine the role of iASPP in acute leukemia (AL), we analyzed iASPP mRNA expression in AL by semi-quantitative reverse transcriptase polymerase chain reaction (RT-PCR). PCR products were confirmed by restriction endonuclease BstX I digestion and sequencing analysis. The results showed that median levels of iASPP gene expression in cells of AL were significantly higher than those in cells from normal donors and AL patients in complete remission (CR) (P = 0.019, 0.021, respectively). There was no significant difference between acute lymphocytic leukemia (ALL) cells and acute myeloid leukemia (AML) cells (P = 0.593). The expression level of iASPP gene and its overexpression in M3 and M4EO were significantly lower than in other subtypes of AML. However, iASPP gene expression in AL cells was not associated with gender, age, initial white blood cell count or p53 type, but was associated with CD34 expression. The results of the present study suggest that iASPP gene overexpression may play an important role in the leukemogenesis and/or disease progression of AL.

Analysis of FLT3 internal tandem duplication and D835 mutations in Chinese acute leukemia patients

Leukemia Research, 2005

Genomic aberrations of Fms-like tyrosine kinase 3 (FLT3), including internal tandem duplication (... more Genomic aberrations of Fms-like tyrosine kinase 3 (FLT3), including internal tandem duplication (ITD) and point mutations, have been demonstrated in 25-30% of adults acute myeloid leukemia (AML) and are markers of poor prognosis. FLT3/ITD and D835 mutations were analyzed in 194 Chinese patients with acute leukemia and myelodysplastic syndromes (MDS) by polymerase chain reaction (PCR). FLT3/ITDs and D835 mutations were found in 25.9 and 6.3% of 143 AML patients, respectively. Two patients showed both ITD and point mutations. Among the FAB subtypes of AML, the rate of FLT3 aberration was significantly higher in M3 and M5. However, neither aberrations was found in 25 patients with acute lymphoblastic leukemia (ALL), 2 acute hybrid leukemia, 17 MDS and 7 chronic myeloid leukemia in blast crisis (CML-BC). FLT3/ITD was associated to leukocytosis and lower complete remission (CR) rate, and was more prevalent in patients with normal karyotype. In contrast, D835 mutation was not associated with leukocytosis or low CR rate. Our results confirm that FLT3 activating mutations also occur in a significant percentage in Chinese AML patients. FLT3/ITD(+) patients treated with standard induction regimen could achieve lower complete remission rates compared with patients not harboring this defect. Early detection of FLT3 mutations and an intensification of induction therapy might thus be useful for this group of patients to overcome the poor prognosis.

siRNA-mediated down-regulation of iASPP promotes apoptosis induced by etoposide and daunorubicin in leukemia cells expressing wild-type p53

by Xinwei Zhang and Jumin Wang

Leukemia Research, 2009

Oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of tumor suppressor p... more Oncoprotein inhibitory member of the ASPP family (iASPP) is a key inhibitor of tumor suppressor p53. Our previous study revealed that the expression of iASPP in acute leukemia (AL) patients was higher than that of normal control which implied that iASPP might play an important role in the pathogenesis and/or disease progression of AL. In this study, the iASPP expression was blocked by RNA interference (RNAi) in two leukemic cell lines, Nalm6 and K562, to explore the effects of iASPP on leukemia cells. The results indicated that down-regulation of endogenous iASPP increased p53-dependent apoptosis of leukemia cells. Thus, iASPP could be a molecular target in leukemia therapy.

Ph-negative acute lymphocytic leukemia occurring after interferon therapy for Ph-positive chronic myelocytic leukemia

Leukemia Research, 2003

We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosom... more We report a unique case of chronic myelocytic leukemia (CML) with the Philadelphia (Ph) chromosome. The patient obtained cytogenetic complete remission (CR) after treatment with interferon (IFN). When he transformed to acute lymphocytic leukemia (ALL), cytogenetic analysis showed that the karyotype was normal and fluorescence in situ hybridization (FISH) indicated that blast cells were Ph-negative. Immunophenotyping showed that the cells were CD34-positive and CD38-negative. Blast cells in his final stage were BCR/ABL rearrangement negative by reverse transcription polymerase chain reaction (RT-PCR).

Selective Interaction of Large or Charge-Transfer Aromatic Molecules with Metallic Single-Wall Carbon Nanotubes: Critical Role of the Molecular Size and Orientation

Journal of the American Chemical Society, 2006

Using first principles calculations, we report for the first time that large nearly neutral aroma... more Using first principles calculations, we report for the first time that large nearly neutral aromatic molecules, such as naphthalene and anthracene, and small charge-transfer aromatic molecules, such as TCNQ and DDQ, interact more strongly with metallic single-wall carbon nanotubes (SWNTs) versus their semiconducting counterparts as the molecular orientation of DDQ is taken into account. Hence two new mechanisms for separating metallic and semiconducting SWNTs via noncovalent π-π stacking or chargetransfer interaction are suggested.

Large-Scale Separation of Metallic and Semiconducting Single-Walled Carbon Nanotubes

Journal of the American Chemical Society, 2005

In the applications of single-walled carbon nanotubes (SWNTs), it is extremely important to separ... more In the applications of single-walled carbon nanotubes (SWNTs), it is extremely important to separate semiconducting and metallic SWNTs. Although several methods have been reported for the separation, only low yields have been achieved at great expense. We show a separation method involving a dispersion-centrifugation process in a tetrahydrofuran solution of amine, which makes metallic SWNTs highly concentrated to 87% in a simple way.

Sulfated SnO2 modified multi-walled carbon nanotubes – A mixed proton–electron conducting support for Pt catalysts in direct ethanol fuel cells

Journal of Power Sources, 2011

We report on the synthesis of sulfated SnO 2 modified multi-walled carbon nanotubes (MWCNTs) comp... more We report on the synthesis of sulfated SnO 2 modified multi-walled carbon nanotubes (MWCNTs) composites as new supports of Pt catalyst (Pt-S-SnO 2 /MWCNTs) with the aims to enhance electron and proton conductivity and also catalytic activity for ethanol oxidation. The Pt-S-SnO 2 /MWCNTs catalyst is synthesized by a combination of improved sol-gel and pulse-microwave assisted polyol methods. The surface presence, morphology and structure of the Pt-S-SnO 2 /MWCNTs catalyst are characterized by Fourier transform infrared spectroscopy (FT-IR), high-resolution transmission electron microscopy (HRTEM) and X-ray diffraction (XRD), respectively. The electrocatalytic properties of the Pt-S-SnO 2 /MWCNTs catalyst for ethanol oxidation reactions are investigated by cyclic voltammetry, chronoamperometry and electrochemical impedance spectroscopy. The results show that Pt-S-SnO 2 /MWCNTs catalyst exhibits higher catalytic activity for ethanol oxidation than Pt supported on non-sulfated SnO 2 /MWCNTs composites.

Identification of a Novel Isoform of iASPP and its Interaction with p53

Journal of Molecular Biology, 2007

iASPP is an inhibitory member of ASPP (apoptosis stimulating protein of p53, or Ankyrin repeats, ... more iASPP is an inhibitory member of ASPP (apoptosis stimulating protein of p53, or Ankyrin repeats, SH3 domain and proline-rich region contain Protein) family. As reported previously, it at least includes two isoforms, one is iASPP/RAI (351 amino acids, aa) and the other is iASPP (828 aa). Here, we identified a novel open reading frame of human iASPP, which encodes a 407 aa protein and highly matches with the C terminus of iASPP (828 aa, CAI60219). Hereafter, iASPP (407 aa) will be referred to as iASPP-SV (iASPP splice variant). In further study, we found that iASPP-SV is a nuclear protein, and is capable of binding to p53 in vivo. Moreover, overexpression of iASPP-SV can inhibit the transcriptional activity of p53 on the promoters of both Bax and p21.

An efficient numerical method of Landau–Brazovskii model

Journal of Computational Physics, 2008

Using the Landau-Brazovskii model, a new numerical implementation is developed to investigate the... more Using the Landau-Brazovskii model, a new numerical implementation is developed to investigate the phase behavior of the diblock copolymer system. Though the method is based on the Fourier expansion of order parameter, a priori symmetric information is not required, and more significantly, the period structure can be adjusted automatically during the iteration as well. The method enables us to calculate the phase diagram, discover new meta-stable phases, validate the epitaxial relation in the phase transition process, and find the inefficiency of the Landau-Brazovskii model for some situations.