Papers by mahmoud Aljoumhawy
A general procedure for connecting dodecaborate clusters to organic building blocks has been foun... more A general procedure for connecting dodecaborate clusters to organic building blocks has been found, using boronic acids as functional groups on the organic moiety, reacting under Suzuki-Miyaura coupling conditions with iodo-undecahydridododecaborate. The choices of ligand (DavePhos) and solvent (N-methylpyrrolidone for electron-poor, CD3CN for electron-rich groups) are essential for the success of the coupling. The procedure is not sensitive to the presence of other functional groups which are unable to participate in Suzuki-Miyaura reactions.
Chemical Communications, 2022
Structure–activity relationships of dodecaborate-substituted nitroanilines as hosts in cyclodextr... more Structure–activity relationships of dodecaborate-substituted nitroanilines as hosts in cyclodextrins have been elucidated.
BMJ Open Ophthalmology
ObjectivesTo develop a new dye formulation for vitreoretinal surgery, which shows increased trans... more ObjectivesTo develop a new dye formulation for vitreoretinal surgery, which shows increased transparency for better intraoperative handling with better parameters important for use.Methods and analysisA new blue dye, DDG, was synthesised and tested for toxicity and staining. Diglycerol as new density-increasing additive was identified, and its toxicity and lack of influence of the staining with trypan blue (TB) on a collagen membrane as model for the epiretinal membrane was determined. Transparency of the dye solution was evaluated.ResultsDDG is as alternative to Brilliant Blue G (BBG), with good staining properties for interna limitans models, and a good safety profile. Diglycerol is a new non-toxic additive replacing PEG3350, with reduced viscosity and no reduction in staining, allowing the reduction of TB to achieve the same staining level of the collagen membrane by 40%, with greater transparency of the dye solution and reduced viscosity. Both factors should facilitate a safe re...
Chemical Communications, 2021
A method is described which allows the synthesis of nitrogen-substituted hydridododecaborate clus... more A method is described which allows the synthesis of nitrogen-substituted hydridododecaborate clusters through Pd-catalyzed cross-coupling.
Journal of Organometallic Chemistry
Advanced Synthesis & Catalysis
We report broad guidance on how to catalyze enantioselective aldehyde additions to nitroalkene or... more We report broad guidance on how to catalyze enantioselective aldehyde additions to nitroalkene or maleimide Michael electrophiles in the presence of unprotected acidic spectator groups, e.g., carboxylic acids, acetamides, phenols, catechols, and maleimide NH groups. Remarkably, these L-threonine and L-serine potassium salt catalyzed reactions proceed even when the nucleophilic and electrophilic Michael partners simultaneously contain acidic spectator groups. These findings begin to address the historical non-compatibility of enantioselective catalytic reactions in the presence of acidic moieties and simultaneously encroach on the reaction capabilities normally associated with cellular environments. A carboxylate salt bridge, from the catalyst enabled enamine, to the Michael electrophile is thought to facilitate the expanded Michael substrate profile. A practical outcome of these endeavors is a new synthetic route to (R)-Pristiq, (-)-O-desmethylvenlafaxine, an antidepressant, in the highest yield known to date because no protecting groups are required.
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Papers by mahmoud Aljoumhawy