saminu Muhammad

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Abhishek K U M A R Verma

Mewar University,Chittorgarh

Mudassir lawal

Federal University, Dutsin-Ma,

University of Ibadan Nigeria

Dr. Saumya Patel

Gujarat Technological University

Aliyu Mahmud

Madhu Sudhana Saddala

Sri Venkateswara University

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Papers by saminu Muhammad

Virtual Screening, Molecular Docking, and ADME/T Analysis of Natural Product Library against Cell Invasion Protein SipB from Salmonella enterica serotype typhi: In Silico Analysis

Acta Scientific Pharamaceutical Sciences, 2020

Keywords: Salmonella enterica; Serotype typhi; Cell Invasion Protein SipB; Natural Product Librar... more Keywords: Salmonella enterica; Serotype typhi; Cell Invasion Protein SipB; Natural Product Library; Molecular Docking Background: The most dangerous issue in the healthcare arises is outbreak of the antibiotic-resistant bacteria worldwide. The randomness of Salmonella infections rely on its serotypes and the immune response of the host. Children up to age of 5 years and patients of older age are prone to the salmonella infections. The virulence genes of Salmonella encodes five different groups of Cell invasion proteins (CIPs), including Sip A, B, C, D and E. Upon contact with the target cell, SipB undergo ‘type III’ export from the bacterial cytoplasm and translocate into the cell membrane. Caspase-1 activity is essential for the cytotoxicity, and it has been proven that binding of SipB to caspase-1 induces macrophage apoptosis, so functional inhibition of caspase-1 blocks macrophage cytotoxicity. Methods: This study is to determine the components of the natural origin compounds (NO...