ATG12
Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Autophagy-related protein 12 is a protein that in humans is encoded by the ATG12 gene.[1][2]
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998).[supplied by OMIM][2]
Autophagy requires the covalent attachment of the protein Atg12 to ATG5 through a ubiquitin-like conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of ATG8 to the lipid phosphatidylethanolamine.[3]
Atg12 was found to be involved in apoptosis. This protein promotes apoptosis through an interaction with anti-apoptotic members of the Bcl-2 family.[4]
References
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- ↑ 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.
- ↑ J. Geng, and D. J. Klionsky, 'The Atg8 and Atg12 Ubiquitin-Like Conjugation Systems in Macroautophagy. 'Protein Modifications: Beyond the Usual Suspects' Review Series', EMBO Rep, 9 (2008), 859-64.
- ↑ A. D. Rubinstein, M. Eisenstein, Y. Ber, S. Bialik, and A. Kimchi, 'The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis', Mol Cell, 44 (2011), 698-709
Further reading
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