Ablukast

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Ablukast
Systematic (IUPAC) name
File:Ablukast.png
6-acetyl-7-[5-(4-acetyl-3-hydroxy-2-propylphenoxy)pentoxy]chroman-2-carboxylic acid
Identifiers
CAS Number	96566-25-5
ATC code	none
PubChem	CID: 57109
ChemSpider	51496^Y
UNII	000TKM5BBQ^Y
KEGG	D02739^Y
ChEMBL	CHEMBL22016^Y
Chemical data
Formula	C₂₈H₃₄O₈
Molecular mass	498.565 g/mol
SMILES CCCC1=C(C=CC(=C1O)C(=O)C)OCCCCCOC2=CC3=C(CCC(O3)C(=O)O)C=C2C(=O)C
InChI InChI=1S/C28H34O8/c1-4-8-21-23(12-10-20(17(2)29)27(21)31)34-13-6-5-7-14-35-26-16-25-19(15-22(26)18(3)30)9-11-24(36-25)28(32)33/h10,12,15-16,24,31H,4-9,11,13-14H2,1-3H3,(H,32,33)^Y Key:FGGYJWZYDAROFF-UHFFFAOYSA-N^Y

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Ablukast (INN) is a leukotriene antagonist which has applications in the treatment of inflammatory skin conditions.^[1]

References

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BLT₁	Agonists: 12-HETE 20-Hydroxy-LTB₄ Leukotriene B₄ LY-255283 Antagonists: 20-Carboxy-LTB₄ Amelubant CGS-23131 (LY-223982) CGS-25019C CP-105696 CP-195543 Etalocib LY-293111 Moxilubant ONO-4057 RG-14893 RP-69698 SB-209247 SC-53228 Ticolubant U-75302 ZK-158252
BLT₂	Agonists: 12-HETE 12-HHT 12-HpETE 15-HETE 15-HpETE 20-Hydroxy-LTB₄ Leukotriene B₄ Antagonists: CP-195543 LY-255283 ZK-158252

CysLT₁	Agonists: Leukotriene C₄ Leukotriene D₄ Leukotriene E₄ Antagonists: Ablukast BAYu9773 BAYu9916 BAYx7195 Cinalukast FPL-55712 ICI-198615 Iralukast LY-170680 Masilukast MK-571 Montelukast ONO-1078 Pobilukast Pranlukast Ritolukast SKF-104353 SR-2640 Sulukast Tipelukast Tomelukast Verlukast Zafirlukast ZD-3523
CysLT₂	Agonists: Leukotriene C₄ Leukotriene D₄ Leukotriene E₄ Antagonists: BAYu9773 BAYu9916
CysLT_E	Agonists: Leukotriene E₄

5-Lipoxygenase	2-TEDC Baicalein BW-A4C BW-B70C Caffeic acid CDC CJ-13610 Curcumin Hyperforin Hypericum perforatum (St. John's Wort) Meclofenamic acid (meclofenamate) Minocycline N-Stearoyldopamine Timegadine Zileuton FLAP inhibitors: AM-103 AM-679 BAYx1005 MK-591 MK-886
12-Lipoxygenase	2-TEDC 3-Methoxytropolone Baicalein CDC
15-Lipoxygenase	2-TEDC CDC Luteolin PD-146176
LTA₄ hydrolase	Acebilustat Captopril DG-051 Fosinoprilat JNJ-26993135 SA-6541 SC-57461A Ubenimex (bestatin)
LTB₄ ω-hydroxylase	17-Octadecynoic acid
LTC₄ synthase	Azelastine MK-886
LTC₄ hydrolase	Acivicin Serine-borate complex
LTD₄ hydrolase	Cilastatin Ubenimex (bestatin)

Others

See also: Prostanoids

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