Anthony Pawson

Anthony Pawson
Born	Anthony James Pawson (1952-10-18)October 18, 1952 Maidstone, England
Died	Toronto, Ontario
Nationality	British-Canadian
Fields	Genetics, microbiology
Institutions	University of Toronto Mount Sinai Hospital, Toronto Samuel Lunenfeld Research Institute
Alma mater	University of Cambridge King's College London
Known for	Cellular signal transduction
Notable awards	Flavelle Medal (1998) Wolf Prize in Medicine (2005) Royal Medal (2005) Kyoto Prize (2008) Fellow of the Royal Society

Anthony "Tony" James Pawson, OC OOnt CH FRS FRSC (October 18, 1952 – August 7, 2013), was a British-born Canadian scientist whose research has revolutionized the understanding of signal transduction, the molecular mechanisms by which cells respond to external cues, and how they communicate with each other. He identified the phosphotyrosine-binding Src homology 2 (SH2 domain) as the prototypic non-catalytic interaction module. SH2 domains serve as a model for a large family of protein modules that act together to control many aspects of cellular signaling. Since the discovery of SH2 domains, hundreds of different modules have been identified in many proteins.

Biography

Born in Maidstone, England, the son of the cricketer and writer Tony Pawson, and botanist and high-school teacher Hilarie, he was the eldest of three children. He was educated at Winchester College and Clare College, Cambridge where he received a MA in biochemistry followed by a Ph.D. from King's College London in 1976. From 1976 to 1980 he pursued postdoctoral work at the University of California, Berkeley. From 1981 to 1985, he was Assistant Professor in microbiology at the University of British Columbia.

Pawson was a Distinguished Investigator and former Director of Research at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital and Professor in the Department of Molecular Genetics at the University of Toronto both of which he joined in 1985.

Pawson died on August 7, 2013 of unspecified causes, at the age of 60.

Honours and awards

• 1994 Gairdner Foundation International Award
• 1994 Fellow of the Royal Society of London and the Royal Society of Canada
• 1995 Robert L. Noble Prize from the National Cancer Institute of Canada
• 1998 Pezcoller-AACR International Award for Cancer Research
• 1998 Heineken Prize for Biochemistry and Biophysics, Royal Netherlands Academy of Arts and Sciences
• 1998 The Royal Society of Canada Flavelle Medal for meritorious achievement in biological science
• 2000 J. Allyn Taylor International Prize in Medicine
• 2004 Louisa Gross Horwitz Prize from Columbia University
• 2004 Poulsson Medal, the Norwegian Society of Pharmacology and Toxicology
• 2004 Associate of the National Academy of Sciences (US)
• 2004 Member of the American Academy of Arts and Sciences
• 2005 Wolf Prize in Medicine "for his discovery of protein domains essential for mediating protein-protein interactions in cellular signaling pathways, and the insights this research has provided into cancer"
• 2005 The Royal Medal (The Queen's Medal) from The Royal Society of London
• 2006 Companion of Honour
• 2007 Premiers Summit Award
• 2007 Howard Taylor Ricketts Award from University of Chicago
• 2008 Kyoto Prize - "Japan's Nobel" for "Proposing and Proving the Concept of Adapter Molecules in the Signal Transduction"
• 2012 Thomson Reuters Citation Laureates, candidate for Nobel Prize in Medicine “for identification of the phosphotyrosine binding SH2 domain and demonstrating its function in protein-protein interactions”

External links

• Anthony Pawson official website at the Samuel Lunenfeld Research Institute
• The Official Site of Louisa Gross Horwitz Prize
• Online Publications (University of Toronto)
• http://sciencewatch.com/nobel/predictions/cell-signaling-and-control