BAMBI

This article is about the human gene. For the German media award, see Bambi award. For other uses, see Bambi (disambiguation).

BMP and activin membrane-bound inhibitor
Identifiers
Symbols	BAMBI ; NMA
External IDs	OMIM: 604444 MGI: 1915260 HomoloGene: 8215 GeneCards: BAMBI Gene
Gene ontology Molecular function • frizzled binding • type II transforming growth factor beta receptor binding Cellular component • cytoplasm • plasma membrane • integral component of membrane Biological process • transforming growth factor beta receptor signaling pathway • positive regulation of cell proliferation • regulation of cell shape • positive regulation of epithelial to mesenchymal transition • cell migration • negative regulation of transforming growth factor beta receptor signaling pathway • positive regulation of protein binding • positive regulation of catenin import into nucleus • positive regulation of transcription, DNA-templated • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	25805	68010
Ensembl	ENSG00000095739	ENSMUSG00000024232
UniProt	Q13145	Q9D0L6
RefSeq (mRNA)	NM_012342	NM_026505
RefSeq (protein)	NP_036474	NP_080781
Location (UCSC)	Chr 10: 28.68 – 28.68 Mb	Chr 18: 3.51 – 3.52 Mb
PubMed search	[1]	[2]

BMP and activin membrane-bound inhibitor homolog (Xenopus laevis), also known as BAMBI, is a protein which in humans is encoded by the BAMBI gene.

Function

This gene encodes a transmembrane glycoprotein related to the type I receptors of the transforming growth factor-beta (TGF beta) family, whose members play important roles in signal transduction in many developmental and pathological processes. The encoded protein however is a pseudoreceptor, lacking an intracellular serine/threonine kinase domain required for signaling. Similar proteins in frog, mouse and zebrafish function as negative regulators of TGF-beta, which has led to the suggestion that the encoded protein may function to limit the signaling range of the TGF-beta family during early embryogenesis.

External links

• BAMBI protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.