Cathepsin A

Cathepsin A
250px PDB rendering based on 1ivy.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1IVY, 3BP4, 3BP7, 3BXN, 4AZ0, 4AZ3, 4CI9, 4CIA, 4CIB, 4MWS, 4MWT
Identifiers
Symbols	CTSA ; GLB2; GSL; NGBE; PPCA; PPGB
External IDs	OMIM: 613111 MGI: 97748 HomoloGene: 80163 ChEMBL: 6115 GeneCards: CTSA Gene
EC number	3.4.16.5
Gene ontology Molecular function • carboxypeptidase activity • serine-type carboxypeptidase activity • enzyme activator activity Cellular component • nucleoplasm • lysosome • endoplasmic reticulum • membrane • lysosomal lumen • intracellular membrane-bounded organelle • extracellular exosome Biological process • dolichol-linked oligosaccharide biosynthetic process • proteolysis • sphingolipid metabolic process • glycosphingolipid metabolic process • intracellular protein transport • protein N-linked glycosylation via asparagine • positive regulation of catalytic activity • post-translational protein modification • cellular protein metabolic process • small molecule metabolic process Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE CTSA 200661 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5476	19025
Ensembl	ENSG00000064601	ENSMUSG00000017760
UniProt	P10619	P16675
RefSeq (mRNA)	NM_000308	NM_001038492
RefSeq (protein)	NP_000299	NP_001033581
Location (UCSC)	Chr 20: 45.89 – 45.9 Mb	Chr 2: 164.83 – 164.84 Mb
PubMed search	[1]	[2]

Cathepsin A is an enzyme that is classified both as a cathepsin and a carboxypeptidase. In humans, it is encoded by the CTSA gene.

Function

This gene encodes a glycoprotein that associates with lysosomal enzymes beta-galactosidase and neuraminidase to form a complex of high-molecular-weight multimers. The formation of this complex provides a protective role for stability and activity. It is protective for β-galactosidase and neuraminidase.

Clinical significance

Deficiencies in this gene are linked to multiple forms of galactosialidosis.

Interactions

Cathepsin A has been shown to interact with NEU1.

External links

• Cathepsin A at the US National Library of Medicine Medical Subject Headings (MeSH)