Diphtheria vaccine
Vaccine description | |
---|---|
Target disease | Corynebacterium diphtheriae |
Type | Toxoid |
Clinical data | |
MedlinePlus | a607027 |
Routes of administration |
Intramuscular injection |
Identifiers | |
ATC code | J07AF01 (WHO) |
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Diphtheria vaccine is a vaccine used against Corynebacterium diphtheriae, the agent that causes diphtheria.[1] It use has resulted in a more than 90% decrease in number of cases globally between 1980 and 2000.[2] Three initial doses are recommended after which it is about 95% effective.[2] It is effective for about 10 years at which time a booster dose is needed.[2] Immunization may start at six weeks of age with further doses given every four weeks.[2]
The diphtheria vaccine is very safe.[2] Significant side effects are rare.[2] Pain may occur at the injection site.[2] A bump may form at the site of injection that lasts a few weeks.[3] The vaccine is safe in both pregnancy and among those who have a poor immune function.[3]
Several combination vaccines are used to prevent diphtheria.[4] This includes with tetanus toxoid (known as dT or DT vaccine) and with tetanus and pertussis vaccine known as DPT vaccine.[2] The World Health Organization has recommended it use since 1974.[2] About 84% of the world population is vaccinated.[5] It is given as a intramuscular injection.[2] The vaccine needs to be kept cold but not frozen.[3]
The diphtheria vaccine was developed in 1923.[6] It is on the World Health Organization's List of Essential Medicines, the most important medication needed in a basic health system.[7] The wholesale price of a version that contains tetanus toxoid is between 0.12 and 0.99 USD per dose as of 2014.[8] In the United States it is less than 25 USD.[9]
References
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External links
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