Endomysium

Endomysium
Structure of a skeletal muscle. (Endomysium labeled at bottom center.)
Identifiers
Code	TH H3.03.00.0.00004
Dorlands /Elsevier	e_08/12332479
TA
TH	{{#property:P1694}}
TE	{{#property:P1693}}
FMA	{{#property:P1402}}
Anatomical terminology [[[d:|edit on Wikidata]]]

The endomysium, meaning within the muscle, is a wispy layer of areolar connective tissue that ensheaths each individual myocyte (muscle fiber, or muscle cell). It also contains capillaries and nerves. It overlies the muscle fiber's cell membrane: the sarcolemma. Endomysium is the deepest and smallest component of connective tissue.

The term cardiac skeleton is sometimes considered synonymous with endomysium in the heart, but cardiac skeleton also refers to the combination of the endomysium and perimysium.

This thin layer provides the correct chemical environment for the exchange of calcium, sodium, and potassium. The exchange of these ions leads to the excitation of the muscle fiber.

Endomysium combines with perimysium and epimysium to create the collagen fibers of tendons, providing the tissue connection between muscles and bones by indirect attachment.

The elastic fiber of collagen is the major protein that composes connective tissues like endomysium. Endomysium has been shown to contain mainly type I and type III collagen components, and type IV and type V in very minor amounts.

Anti-endomysial antibodies (EMA) are present in celiac disease. They do not cause any direct symptoms to muscles, but detection of EMA is useful in the diagnosis of the disease.

See also

• Perimysium
• Epimysium
• Connective tissue in skeletal muscle

External links

• UIUC Histology Subject 777
• Illustration at wku.edu
• Anatomy photo: Musculoskeletal/muscle/skeletal1/skeletal3 - Comparative Organology at University of California, Davis
• MedEd at Loyola histo/practical/muscle/hp7-42.html