Fomivirsen

Fomivirsen

Clinical data
AHFS/Drugs.com	Micromedex Detailed Consumer Information
Pregnancy category	AU: B2
Routes of administration	Intravitreal injection
Identifiers
CAS Number	160369-77-7 Y
ATC code	S01AD08 (WHO)
KEGG	D02736 Y
ChEMBL	CHEMBL1201688 N
Chemical data
Formula	C204H263N63O114P20S20
Molecular mass	6682.4 g/mol
NY (what is this?)  (verify)

Fomivirsen (brand name Vitravene) is an antiviral drug. It is used in the treatment of cytomegalovirus retinitis (CMV) in immunocompromised patients, including those with AIDS. It was licensed by the FDA for CMV in Aug 1998.

It is a synthetic 21 member oligonucleotide with phosphorothioate linkages (which are resistant to degradation by nucleases) and has the sequence:

• 5'-GCG TTT GCT CTT CTT CTT GCG-3'

Mechanism

It is an oligonucleotide that blocks translation of viral mRNA by binding to the complementary sequence of the mRNA transcribed from the template segment of a key CMV gene. It was the first antisense antiviral approved by the FDA.

Administration

It is available as an intraocular injection in a concentration of 6.6 mg/mL.

See also

• retinitis

External links

• MedlinePlus DrugInfo uspdi-203675
• DDB 31313