GPR177

Wntless Wnt ligand secretion mediator
Identifiers
Symbols	WLS ; C1orf139; EVI; GPR177; MRP; mig-14
External IDs	OMIM: 611514 MGI: 1915401 HomoloGene: 11779 GeneCards: WLS Gene
Gene ontology Molecular function • signal transducer activity • protein binding • Wnt-protein binding • mu-type opioid receptor binding Cellular component • Golgi membrane • plasma membrane • integral component of membrane • cytoplasmic vesicle membrane • early endosome membrane • dendrite membrane • dendrite cytoplasm Biological process • mesoderm formation • anterior/posterior axis specification • Wnt signaling pathway • positive regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of canonical Wnt signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	79971	68151
Ensembl	ENSG00000116729	ENSMUSG00000028173
UniProt	Q5T9L3	Q6DID7
RefSeq (mRNA)	NM_001002292	NM_026582
RefSeq (protein)	NP_001002292	NP_080858
Location (UCSC)	Chr 1: 68.1 – 68.23 Mb	Chr 3: 159.84 – 159.94 Mb
PubMed search	[1]	[2]

G protein-coupled receptor 177 (GPR177), commonly known as Wntless, is a human gene that encodes a receptor for Wnt proteins in Wnt-secreting cells.

Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.

See also

• GPR177 receptor, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.