Glycerophosphodiester phosphodiesterase

glycerophosphodiester phosphodiesterase
Identifiers
EC number	3.1.4.46
CAS number	Template:CAS
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glycerophosphodiester phosphodiesterase (EC 3.1.4.46) is an enzyme that catalyzes the chemical reaction

a glycerophosphodiester + H₂O $\rightleftharpoons$ an alcohol + sn-glycerol 3-phosphate

Thus, the two substrates of this enzyme are glycerophosphodiester and H₂O, whereas its two products are alcohol and sn-glycerol 3-phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric diester bonds. The systematic name of this enzyme class is glycerophosphodiester glycerophosphohydrolase. Other names in common use include gene hpd protein, glycerophosphoryl diester phosphodiesterase, and IgD-binding protein D. This enzyme participates in glycerophospholipid metabolism.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes 1O1Z, 1T8Q, 1V8E, 1VD6, 1YDY, 2DXL, 2DXN, 2OOG, and 2P76.