Guselkumab

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Guselkumab
Monoclonal antibody
Type ?
Source Human
Target IL23
Identifiers
CAS Number 1350289-85-8
ATC code none
Chemical data
Formula C6402H9864N1676O1994S42
Molecular mass 143.6 kg/mol

Guselkumab is a monoclonal antibody designed for the treatment of psoriasis.[1]

By targeting the p19 subunit[2] (which is not part of IL-12) guselkumab was designed to block interleukin-23 but not IL-12. Interleukin 23 is a cytokine that plays an important role in managing the immune system and autoimmune disease. This drug was developed by Janssen Global Services, LLC.

As of March 2014, the drug was in phase II clinical trials for plaque psoriasis. Phase II data released at the 2014 annual conference of the American Academy of Dermatology showed that up to 88% of patients treated with guselkumab achieved a Physician Global Assessment (PGA) score of cleared or minimal disease activity.[3]

See also

  • Ustekinumab, a monoclonal antibody targeting both IL-12 and IL-23 and used to treat plaque psoriasis, launched in the United States under the brand name Stelara
  • Tildrakizumab, another experimental, IL-23-specific monoclonal antibody

References

  1. ↑ Statement On A Nonproprietary Name Adopted By The USAN Council - Guselkumab, American Medical Association.
  2. ↑ Lua error in package.lua at line 80: module 'strict' not found.
  3. ↑ http://www.medpagetoday.com/Dermatology/Psoriasis/44889


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