HBD

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Lua error in Module:Infobox_gene at line 33: attempt to index field 'wikibase' (a nil value). Hemoglobin subunit delta is a protein that in humans is encoded by the HBD gene.[1]

Function

The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5' - epsilongamma-Ggamma-Adeltabeta - 3'.[2]

Clinical significance

Mutations in the delta-globin gene are associated with Delta-thalassemia.[2]

See also

References

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  2. 2.0 2.1 Lua error in package.lua at line 80: module 'strict' not found.

Further reading

  • Lua error in package.lua at line 80: module 'strict' not found.
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