HLA-DR3
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major histocompatibility complex, class II, DR3
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| Haplotypes groups | DRA*01:DRB1*0301 DRA*01:DRB1*0302 DRA*01:DRB1*0303 DRA*01:DRB1*0304 | |
| Structure (See HLA-DR) | ||
| Identifiers |
alpha *0101
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| Symbol(s) | HLA-DRA | |
| EBI-HLA | DRA*0101 | |
| Identifiers |
beta 1 *0301 *0301 *0302 *0303 *0304
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| Symbol(s) | HLA-DRB1 | |
| EBI-HLA | DRB1*0301 | |
| EBI-HLA | DRB1*0302 | |
| EBI-HLA | DRB1*0303 | |
| EBI-HLA | DRB1*0304 | |
| EBI-HLA | DRB1*0305 | |
| Shared data | ||
| Locus | chr.6 6p21.31 | |
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is strongly associated with HLA-DR3 or HLA-DR4.
Contents
Serology
| DRB1* | DR3 | DR17 | DR18 | Sample |
| allele | % | % | % | size (N) |
| 0301 | 33 | 64 | 0 | 9698 |
| 0302 | 24 | 3 | 66 | 317 |
| 0303 | 40 | 60 | 5 | |
| 0304 | 60 | 20 | 5 | |
| 0307 | >50 | 1 |
Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*0304 primarily reacts with DR3. The serotypes of *0305, *0306, *0308 to *0331 are unknown.
Disease associations
By serotype
HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimoto's thyroiditis (along with DR5), primary sclerosing cholangitis,[2] and opportunistic infections in AIDS,[3] but lowered risk for cancers.[4]
By allele
DRB1*0301 (see HLA-DR17)
DRB1*0302 (See HLA-DR18)
DRB1*0304 is associated with graves disease[5]
By haplotypes
DR3 and/or DQ2 is associated with Moreen's ulceration,[6] "bout onset" multiple sclerosis,[7] Grave's disease[8] and systemic lupus erythematosus[9]
DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, Diabetes mellitus type 1. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*0501 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however is older studies DQA1*0505 is commonly confused with DQA1*0501)
[10]
Genetic linkage
DR3 is genetically linked to HLA-DR52, DRB3*0202 allele, and HLA-DQ2 (DQ2.5).
References
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