Interleukin 32

Interleukin 32
Identifiers
Symbols	IL32 ; IL-32alpha; IL-32beta; IL-32delta; IL-32gamma; NK4; TAIF; TAIFa; TAIFb; TAIFc; TAIFd
External IDs	OMIM: 606001 HomoloGene: 128400 GeneCards: IL32 Gene
Gene ontology Molecular function • cytokine activity • protein binding Cellular component • extracellular space • membrane Biological process • defense response • immune response • cell adhesion Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	9235	n/a
Ensembl	ENSG00000008517	n/a
UniProt	P24001	n/a
RefSeq (mRNA)	NM_001012631	n/a
RefSeq (protein)	NP_001012649	n/a
Location (UCSC)	Chr 16: 3.07 – 3.08 Mb	n/a
PubMed search	[1]	n/a

Interleukin 32 is a protein that in humans is encoded by the IL32 gene.

Function

This gene encodes a member of the cytokine family. The protein contains a tyrosine sulfation site, 3 potential N-myristoylation sites, multiple putative phosphorylation sites, and an RGD cell-attachment sequence. Expression of this protein is increased after the activation of T-cells by mitogens or the activation of NK cells by IL-2. This protein induces the production of TNF-alpha from macrophage cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interleukin 32 (IL-32) is a pro-inflammatory cytokine that can induce cells of the immune system (such as monocytes and macrophages) to secrete inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and IL-6. In addition, it can also induce the production of chemokines such as IL-8 and MIP-2 / CXCL2.

IL-32 can also support osteoclast differentiation but not osteoclast activation by regulating the MAPK/ERK pathway and the actin cytoskeleton.

References

This article incorporates text from the United States National Library of Medicine, which is in the public domain.