LBX1

Ladybird homeobox 1
Identifiers
Symbols	LBX1 ; HPX-6; HPX6; LBX1H; homeobox
External IDs	OMIM: 604255 MGI: 104867 HomoloGene: 4784 GeneCards: LBX1 Gene
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • sequence-specific DNA binding Cellular component • nucleus • transcription factor complex Biological process • heart looping • transcription, DNA-templated • muscle organ development • negative regulation of cell proliferation • anatomical structure morphogenesis • spinal cord motor neuron differentiation • regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification • negative regulation of neuron differentiation • neuron fate determination Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE LBX1 208380 at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10660	16814
Ensembl	ENSG00000138136	ENSMUSG00000025216
UniProt	P52954	P52955
RefSeq (mRNA)	NM_006562	NM_010691
RefSeq (protein)	NP_006553	NP_034821
Location (UCSC)	Chr 10: 101.23 – 101.23 Mb	Chr 19: 45.23 – 45.24 Mb
PubMed search	[1]	[2]

Transcription factor LBX1 is a protein that in humans is encoded by the LBX1 gene.

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.