LHX2

LIM homeobox 2
250px PDB rendering based on 2dmq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2dmq
Identifiers
Symbols	LHX2 ; LH2; hLhx2
External IDs	OMIM: 603759 MGI: 96785 HomoloGene: 55848 GeneCards: LHX2 Gene
Gene ontology Molecular function • transcription factor activity, RNA polymerase II transcription factor binding • chromatin binding • zinc ion binding • sequence-specific DNA binding Cellular component • nucleus Biological process • neural tube closure • hair follicle development • transcription from RNA polymerase II promoter • axon guidance • mesoderm development • dorsal/ventral pattern formation • olfactory bulb development • telencephalon regionalization • cerebral cortex development • maintenance of epithelial cell apical/basal polarity • positive regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • axon extension • retina development in camera-type eye • negative regulation of transcription regulatory region DNA binding Sources: Amigo / QuickGO
RNA expression pattern
File:PBB GE LHX2 206140 at tn.png
File:PBB GE LHX2 211219 s at tn.png
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9355	16870
Ensembl	ENSG00000106689	ENSMUSG00000000247
UniProt	P50458	Q9Z0S2
RefSeq (mRNA)	NM_004789	NM_001290646
RefSeq (protein)	NP_004780	NP_001277575
Location (UCSC)	Chr 9: 124 – 124.03 Mb	Chr 2: 38.34 – 38.37 Mb
PubMed search	[1]	[2]

LIM/homeobox protein Lhx2 is a protein that in humans is encoded by the LHX2 gene.

This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution.

Interactions

LHX2 has been shown to interact with CITED2.