Latanoprostene bunod

Latanoprostene bunod

File:Latanoprostene bunod.svg
Systematic (IUPAC) name
4-Nitrooxybutyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-[(3R)-3-hydroxy-5-phenylpentyl]cyclopentyl]hept-5-enoate
Clinical data
Trade names	Vyzulta
AHFS/Drugs.com	Multum Consumer Information
Licence data	US Daily Med:bunod link
Legal status	CA: ℞-only US: ℞-only
Identifiers
CAS Number	860005-21-6
ATC code	S01EE06 (WHO)
PubChem	CID: 11156438
DrugBank	DB11660
ChemSpider	9331546
UNII	I6393O0922
KEGG	D10441
Synonyms	BOL-303259-X
Chemical data
Formula	C27H41NO8
Molecular mass	507.62 g·mol−1
SMILES C1[C@H]([C@@H]([C@H]([C@H]1O)C/C=C\CCCC(=O)OCCCCO[N+](=O)[O-])CC[C@H](CCC2=CC=CC=C2)O)O
InChI InChI=1S/C27H41NO8/c29-22(15-14-21-10-4-3-5-11-21)16-17-24-23(25(30)20-26(24)31)12-6-1-2-7-13-27(32)35-18-8-9-19-36-28(33)34/h1,3-6,10-11,22-26,29-31H,2,7-9,12-20H2/b6-1-/t22-,23+,24+,25-,26+/m0/s1 Key:LOVMMUBRQUFEAH-UIEAZXIASA-N

Latanoprostene bunod (trade name Vyzulta) is an ophthalmic drug approved in the United States in 2017 for the reduction of intraocular pressure in patients with open-angle glaucoma or ocular hypertension. It targets the trabecular meshwork directly.