Lomustine

Lomustine

Systematic (IUPAC) name
N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea
Clinical data
Trade names	CeeNU
AHFS/Drugs.com	monograph
MedlinePlus	a682207
Pregnancy category	D
Legal status	℞ (Prescription only)
Routes of administration	Oral
Pharmacokinetic data
Bioavailability	~100%
Protein binding	50%
Metabolism	hepatic
Biological half-life	16–48 hours
Identifiers
CAS Number	13010-47-4 Y
ATC code	L01AD02 (WHO)
PubChem	CID: 3950
IUPHAR/BPS	7214
DrugBank	DB01206 Y
ChemSpider	3813 Y
UNII	7BRF0Z81KG Y
KEGG	D00363 Y
ChEBI	CHEBI:6520 N
ChEMBL	CHEMBL514 Y
Synonyms	1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea
Chemical data
Formula	C9H16ClN3O2
Molecular mass	233.695 g/mol
SMILES O=C(NC1CCCCC1)N(N=O)CCCl
InChI InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14) Y Key:GQYIWUVLTXOXAJ-UHFFFAOYSA-N Y
Physical data
Melting point	90 °C (194 °F)
NY (what is this?)  (verify)

Lomustine (INN), also called 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU) (trade name CeeNU in the U.S.) is an alkylating nitrosourea compound used in chemotherapy. It is closely related to semustine and is in the same family as streptozotocin. It is a highly lipid-soluble drug and thus crosses the blood-brain barrier. This property makes it ideal for treating brain tumors, which is its primary use. Lomustine has a long time to nadir (the time when white blood cells reach their lowest number).

External links

• CeeNu (lomustine) Capsules data sheet published by the FDA
• Lomustine at the US National Library of Medicine Medical Subject Headings (MeSH)
• DDB 29525