Luteinizing hormone beta polypeptide

Luteinizing hormone beta polypeptide
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1M92
Identifiers
Symbols	LHB ; CGB4; HH23; LSH-B; hLHB
External IDs	OMIM: 152780 MGI: 96782 HomoloGene: 81806 GeneCards: LHB Gene
Gene ontology Molecular function • receptor binding • hormone activity Cellular component • extracellular region • extracellular exosome Biological process • progesterone biosynthetic process • signal transduction • cell-cell signaling • male gonad development • peptide hormone processing • cellular protein metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3972	16866
Ensembl	ENSG00000104826	ENSMUSG00000100916
UniProt	P01229	G3X9G6
RefSeq (mRNA)	NM_000894	NM_008497
RefSeq (protein)	NP_000885	NP_032523
Location (UCSC)	Chr 19: 49.02 – 49.02 Mb	Chr 7: 45.42 – 45.42 Mb
PubMed search	[1]	[2]

Luteinizing hormone subunit beta also known as lutropin subunit beta is a protein that in humans is encoded by the LHB gene.

Gene

The genes for the beta chains of chorionic gonadotropin and for luteinizing hormone are contiguous on chromosome 19q13.3. In equines, this subunit is encoded by the same gene as the beta subunit of chorionic gonadatropin, subunits which are identical.

Function

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta subunit of luteinizing hormone (LH). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and a unique beta subunit (this protein) which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.

Clinical significance

Mutations in this gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.